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Egrifta SV

Generic Name: Tesamorelin [TES-a” moe-REL-in]

Class of Drugs: Growth Hormones

What is Egrifta SV?

Egrifta SV is made with growth hormone-releasing factor (GRF).Egrifta SV is used to reduce excess fat around the stomach that is caused by taking certain HIV medications. This condition is also called lipodystrophy (LYE-poe-DIS-troe-fee).Egrifta SV is not a weight-loss medication and should not be used to treat obesity.

Side effects of Egrifta SV

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.Stop using Egrifta SV and call your doctor at once if you have a serious side effect, such as:

  • Swelling in your hands, ankles, or feet;
  • Pain or stiffness in your muscles or joints;
  • Pain in your arms or legs;
  • Wrist pain or numbness;
    numbness ordo your fingers or hands tingle or feel numb? Are they experiencing any tingling or numbness?
  • Your chest thump or quiver with each beat.
  • High blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss);

Less serious side effects may include:

  • Depressed mood; sleep problems (insomnia);
  • Night sweats;
  • Mild rash or itching;
    muscle spasm;
  • Nausea, vomiting, upset stomach;
  • Pain, redness, itching, swelling, bruising, bleeding, or other irritation where the injection was given;

Consult a physician if experiencing adverse effects. Any side effects can also be reported directly to the FDA at 1-800-FDA-1088.


Egrifta SV may cause birth defects if taken during gestation. Therefore, pregnant women should avoid taking this medication.You should not use Egrifta SV if you are allergic to it or if you have a history of a tumor or surgery on your pituitary gland, a history of a head injury, or radiation treatment.Before using Egrifta SV, tell your doctor if you have heart disease, high blood pressure, kidney disease, diabetes, epilepsy, asthma, migraines, an adrenal gland disorder, or if you have ever had cancer, any type of tumor, or open heart surgery.Also tell your doctor about any major illness, recent trauma, or medical emergency.

Before you take this drug

You should not use Egrifta SV if you are allergic to it or if you have:

  • Cancer;
  • A pituitary gland disorder;
  • A history of pituitary gland tumors or surgery;
  • A history of head injury or radiation treatment;
  • If you are pregnant.

To make sure you can safely take Egrifta SV, tell your doctor if you have any of these other conditions:

  • A history of cancer or any tumor (either benign or malignant);
    heart disease, high blood pressure;
  • Kidney disease;
  • Diabetes; eye problems caused by diabetes;
  • Epilepsy
  • Asthma;
  • Migraine headaches;
  • Adrenal gland disorder;
  • If you have ever had open heart surgery;
  • If you have a major illness or a recent trauma or medical emergency.

FDA pregnancy category X This medication can harm an unborn baby or cause birth defects. Do not use Egrifta SV if you are pregnant. Tell your doctor right away if you become pregnant during treatment.Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.Do not give Egrifta SV to a child without medical advice.

How to take Egrifta SV?

Egrifta SV is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.This medication comes with injection instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.Egrifta SV is a powder medicine that must be mixed with a liquid (diluent) before use. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed color or has particles in it. Call your doctor for a new prescription.After mixing Egrifta SV with a diluent, you must use it right away. Do not store the mixture for later use.Egrifta SV is usually given once per day. Follow your doctor's dosing instructions very carefully.Use a different place on your stomach each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.Never share an Egrifta SV syringe with another person, even if you change the needle. Sharing syringes or needles can allow HIV or other diseases to pass from one person to another.To make sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested often. Do not miss any follow-up visits to your doctor.Store vials of tesamorelin powder in the refrigerator; do not freeze.Store the diluent at room temperature away from moisture, heat, and light.Throw away any unused vials after the expiration date on the label has passed.

What happens if I miss the dose?

Call your doctor for instructions if you miss a dose of Egrifta SV.

What happens if I overdose?

For medical emergencies, seek immediate medical assistance or call the Poison Help Line at 1-800-222-1222.

What should be avoided?

Do not inject Egrifta SV into scar tissue or on skin that is bruised. Do not inject directly into your navel (belly button).

Interaction with other drugs

Tell your doctor about all other medicines you use, especially:

  • Cyclosporine;
  • Testosterone or hormone replacement therapy;
  • Seizure medication;
  • Steroids;

This list is not complete, and there are many other drugs that can interact with Egrifta SV. Tell your doctor about all the medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.