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Generic name: antihemophilic factor (recombinant) [ant-ee-hee-moe-FIL-ik-FAK-tor]
The class of drug: miscellaneous coagulation modifiers

What is Xyntha?

Xyntha has recombinant antihemophilic factors. Antihemophilic factor is a protein that occurs naturally in blood and aids blood in making clots. Insufficient antihemophilic factor VIII is a cause of haemophilia A.Xyntha acts by temporarily increasing the levels of factor VIII within the blood, which aids in the formation of clots.Xyntha is a medication used to treat or stop bleeding in adults and children suffering from haemophilia A. It can also be used to manage bleeding from dental surgery or other procedures for people with hemophilia. It also helps to avoid joint injury in patients 16 or older with severe haemophilia A but no previous joint damage.Xyntha is not recommended for patients suffering from von Willebrand disease.


You shouldn't make use of Xyntha if you've ever experienced an extreme allergy to antihemophilic factors.Your body could create antibodies to antihemophilic factors, and this can make it less efficient. Consult your physician when this medication appears to not be as effective in reducing the bleeding.Be sure to follow the instructions regarding how to store this medication. Each brand of recombinant antihemophilic factors may come with specific guidelines for conserving the medicine in an airtight container or at room temperature for a limited amount of time.Before taking Xyntha, the specific blood clotting disorder needs to be diagnosed as a factor VIII deficiency. Human antihemophilic factors are not able to treat von Willebrand disease.To make sure that Xyntha has been aiding your condition and not causing harm, the blood of your patient may need to be checked frequently. Visit your doctor regularly.Wear an alert medical tag or carry an ID card that states that you suffer from hemophilia. Any dentist, doctor, or emergency medical professional who treats you should be aware that you suffer from an issue with blood clotting or bleeding.

Before you take this drug

It is not recommended to make use of Xyntha in the event that you've suffered a severe reaction to antihemophilic factor or if you have an allergy to hamster, mouse, or meat proteins.Before you can use Xyntha, the blood clotting disorder needs to be identified as a factor VIII deficiency. Xyntha is not a treatment for von Willebrand disease.To ensure that Xyntha is suitable for you, inform your physician if you suffer from heart disease.It isn't known if it could harm the unborn baby. Consult your physician if you are expecting or planning to become pregnant while taking this medication.It isn't known if the recombinant antihemophilic factor is absorbed into breast milk or whether it can cause harm to a nursing infant. Inform your doctor if you are breastfeeding a baby.

How to take Xyntha?

Make sure you use Xyntha precisely as directed by your physician. Follow the directions on the prescription label. Don't use this medication in smaller or larger quantities or for longer than suggested. Always confirm your dose of medication on the prescription label. This will make certain you are using the right dosage.Xyntha is instilled into a vein via an IV. It is possible to be taught how to inject an IV at home. Don't inject yourself with the medicine when you don't know how to inject it, and dispose of the IV tubing, needles that are no longer in use, and other devices that are used to inject the medication.Xyntha can be taken at intervals of 8–24 hours over between 1 and 4 days, depending on the reason why you're taking the drug.The medicine comes with instructions on safe and effective use. Follow these guidelines carefully. Consult your physician or pharmacist if you have any concerns.Make sure to wash your hands prior to taking your injections and preparing them.

Xyntha should be mixed with the aid of a liquid (diluent) prior to injecting it. If you keep your medication in a refrigerator, you must take a diluent and medicine vial from the refrigerator and allow them to be at room temperature prior to mixing them.Swirl the medicine and diluent gently until they are mixed, and then allow the medication to completely dissolve.After mixing the medicine with diluent, store the mix at room temperature until you can take it out for 3–4 hours. If you haven't used the mixture within 3 hours, discard it. Don't put mixed medicines in the refrigerator.Make your dose by using a syringe when you are able to administer an injection. A single-use vial is intended for one-time use only. After measuring your dosage, dispose of the vial, regardless of whether there's still medicine within the vial.Do not take Xyntha when it has changed colour or contains particles. Consult your pharmacist about an update on the medications.

Make use of the disposable needle and syringe only once. Make sure you follow any local or state laws regarding disposing of used needles and syringes. Make sure you use a puncture-proof "sharps" disposal container (ask your pharmacist for one and how to dispose of the container away). Make sure this container is away from pets and children.If you're taking Xyntha, it is possible that you will require regular blood tests.The body can develop antibodies against antihemophilic factor, which makes it less efficient. Consult your physician when this medication appears to be less effective in regulating the bleeding.Follow all directions on how to store the medicine. Each recombinant factor might have specific storage guidelines.Keep Xyntha and the dilute in the refrigerator. Do not let them freeze.Before making your dosage and preparing your dose, take the medication and diluent out of your refrigerator and let them be at room temperature.

Xyntha can be stored in a fridge at temperatures of 2°C–8°C (36°F–46°F) for a period of up to 36 months after the time of manufacturing until the expiration date listed in the packaging.Xyntha can be kept at room temperature (below 77 °F) for up to 3 months. If you keep this medication within the room, you should record the date that you started the process of storing Xyntha when it was at room temperature to be aware of the time you should dispose of it. There is a place on the carton to record the date.In storage, try to avoid long-term exposure of Xyntha vials to sunlight. Get rid of any remaining medication and diluent once the expiration date has come and gone.Wear a medical alert tag or carry an ID card stating that you suffer from hemophilia. Any dentist, doctor, or emergency medical provider who treats you should be aware that you suffer from bleeding or blood-clotting disorders.

Do I be concerned if I miss a dose?

Because Xyntha is taken when it is needed and is not a requirement for following a regular dosing regimen, If you're following a routine, take the missed dose as quickly as you can remember. Avoid any missed doses if you are close to the time of the next dose scheduled. Avoid taking any extra medication to take the place of your missed dose.

What will happen if I take excessively?

If you are experiencing medical emergency, seek urgent medical attention, or call to get help from the Poison Help Line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Side effects of Xyntha

See a doctor immediately. If you experience any indications that indicate an allergy reaction to Xyntha, such as difficulty breathing, hives, fainting, feeling lightheaded, and swelling of your lips, face, and throat,

Stop taking Xyntha and consult your physician immediately if you are suffering from:

  • Chest pain;
  • Easily bruising, more bleeding episodes, and
  • Bleeding from a wound or an area where the medication was infected.

Common Xyntha adverse effects could include:

  • Nausea, vomiting, diarrhoea;
  • Headache, dizziness;
  • Joint pain;
  • Rash;
  • Cough, sore throat, congestion of the nose;
  • Feeling tired and weak;
  • Fever
  • Itching, pain, swelling, or irritation at the site in the area where the injection was administered

It isn't a complete description of every side effect. Other side effects could be present. Consult your physician to seek medical advice on adverse effects.If you experience any side reactions to the FDA by calling 1-800-FDA-1088.

Interaction with other drugs

Other medications can interfere with Xyntha, which includes medications that are prescribed and available over the counter, such as vitamins and herbal products. Inform all of your health professionals about the medicines you are taking in the present and about any medication you stop or start taking.