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Generic name: incobotulinumtoxina [IN-koe-BOT-ue-LYE-num-TOX-in-A]
Brand name: Xeomin
Dosage form: intramuscular powder for injection (100 units; 200 units; 50 units)
Drug class: skeletal muscle relaxants

What is IncobotulinumtoxinA (ICT)?

Adults are treated with incobotulinumtoxina to:

  • The muscles of the upper limbs (spasticity) and their spasms (muscle spasms)
  • Cervical dystonia (severe muscle spasms around the neck) or stiffness of the fingers, wrists, ankles, or toes
  • Certain eye muscle disorders caused by nerve disorders, including uncontrolled blinking and spasms of the eyelids,
  • Temporarily reduce the appearance of wrinkles between the eyebrows (also known as "frown lines").

Incobotulinumtoxina can also be used to treat children older than 2 years.

  • Upper-limb spasticity is not caused by cerebral palsy.
  • Chronic drooling.

This medication guide does not list all possible uses of incobotulinumtoxina.

Side effects of IncobotulinumtoxinA

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, wheezing or difficulty breathing, feeling as if you may pass out, swelling of your lips, face, tongue, throat, etc.

This medication contains botulinum toxins that can spread beyond the injection site. Some people who have received botulinum injections for cosmetic reasons or even to treat serious health problems have experienced life-threatening complications.

If you experience any of the following side effects, call your doctor immediately (up to a few hours or a few weeks after an injection).

  • Unusual or severe weakness of the muscles (especially if it occurs in an area not injected with medication);
  • Trouble breathing, speaking, or swallowing
  • Hoarseness and drooping of the eyelids
  • Double vision, or blurred vision, is another name for this phenomenon.
  • Seizure;
  • Eye irritation or pain; vision changes;
  • Wheezing and tightness in the chest
  • Eyelid swelling, crusting, or drainage from the eyes
  • Feeling like you might pass out;
  • Loss of strength and bladder control.

Some of the common side effects associated with incobotulinumtoxin A include:

  • Pain where the medication was injected
  • Tooth problems;
  • Muscle weakness
  • Vision problems
  • Trouble swallowing
  • Dry eyes and drooping lids.
  • Headache; neck pain; body pains
  • A seizure;
  • Increased blood pressure
  • Diarrhea;
  • Cold-like symptoms include a stuffy nose and sneezing. A sore neck is also common, as are coughs and chest congestion.

There may be other side effects. Call your doctor for medical advice about side effects. To report side effects, you can contact the FDA at 1-800-FDA-1088.

Similar/related drugs

Botox, tazarotene topical, onabotulinumtoxina, Botox Cosmetic, Daxxify, Xeomin, and Dysport


Incobotulinumtoxina should not be given to you if your body is allergic to botulinum toxins, if there are any infections or swellings, or if the area of injection has a weakness.

This medicine contains botulinum toxins that can spread beyond the injection site. This can have serious and life-threatening effects.If you experience hoarseness, drooping eyes, severe weakness of the muscles, bladder problems, or trouble speaking, breathing, or swallowing, call your doctor immediately.

Before you take this drug

Incobotulinumtoxina should not be used if the patient is allergic to the toxin or has an infection, swelling, or weakness of the muscles in the area that will be treated.Tell your doctor if a previous botulinum toxin treatment caused you any side effects.

Tell your doctor about any of the following:

  • Other botulinum injections, such as Botox, Dysport, or Myobloc,
  • Lou Gehrig disease, or amyotrophic lateral sclerosis
  • Myasthenia gravis;
  • Lambert-Eaton syndrome;
  • A breathing disorder, such as asthma or emphysema.
  • If you have difficulty swallowing or inhaling food and drink accidentally into your lungs, this could be a sign of a problem.
  • Facial muscle weakness (drooping eyelids, a weak forehead, difficulty raising your eyebrows);
  • A change in your normal facial appearance;
  • A seizure disorder;
  • Bleeding problems
  • Heart disease
  • Surgery

Incobotulinumtoxina, which is made using donated plasma from humans, may contain viruses and other infectious agents. The plasma that is donated is treated and tested to reduce the chance of contamination. However, there is still some risk. You should ask your doctor if there are any risks.

This medicine is not known to harm an unborn child. Inform your doctor if you are pregnant or planning to become pregnant.Breastfeeding may not be possible while taking this medication. You should ask your doctor if there are any risks.

How to take IncobotulinumtoxinA?

Incobotulinumtoxina can be injected into the muscle or gland. This injection is given by a healthcare provider every 12–16 weeks. The injections of incobotulinumtoxina should be separated by at least 12 weeks.

Even when used cosmetically, botulinum toxin injections should only be administered by medical professionals.You may need to inject more than one part at a given time, depending on the condition you are treating.You may be required to use special contact lenses, eye drops, or ointment to protect your eye surface while receiving injections to treat eye muscle disorders. Please follow your doctor's directions.

After the injection, it may take 7 days before you notice any improvement in neck muscle spasms.The effects of the botulinum toxins are only temporary. You may experience a complete return of symptoms within three months. Your symptoms may return sooner after repeated injections. This is especially true if you develop antibodies against the toxin.

Avoid requesting botulinum injections from multiple medical professionals at the same time. Tell your new healthcare provider when you last received a botulinum injection.This medicine will not be more effective if you take it more than the prescribed amount. It may also cause serious side effects.

What happens if I miss the dose?

Missing a dose of botulinum is unlikely to cause harm, as the toxin is only temporary and given at widely separated intervals.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

The symptoms of an overdose may not be apparent immediately, but they can include muscle weakness, difficulty swallowing, shallow or weak breathing, and loss of movement anywhere in your body.

What should be avoided?

Do not return to normal activities immediately after an injection.incobotulinumtoxina can affect your depth perception or vision. Do not drive or engage in hazardous activities until you have determined how the medicine will affect you.

Interaction with other drug

Tell your doctor about your other medications, including:

  • An antibiotic such as amikacin, gentamicin, kanamycin, neomycin, or paromomycin streptomycin tobramycin
  • Muscle relaxers;
  • Medicine to treat depression or anxiety;
  • Cold or allergy medication (Benadryl et al.)
  • Medicine to treat Parkinson’s disease
  • Medicine to treat stomach problems, motion sickness, or irritable bowel syndrome
  • Medicine to treat overactive urinary bladder
  • Asthma medication bronchodilator.

This list is incomplete. Incobotulinumtoxina may be affected by other drugs, such as vitamins and herbs. This list does not include all possible drug interactions.