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Xpovio 40 mg once-weekly

Name of the generic: selinexor selinexor [SEL-i-NEX-or
Brand names: Xpovio 100 mg once-weekly; Xpovio 40 mg once-weekly; Xpovio 40 mg twice-weekly; Xpovio 60 mg once-weekly; Xpovio 60 mg twice-weekly; Xpovio 80 mg once-weekly; Xpovio 80 mg twice-weekly.
Classification of drugs: miscellaneous antineoplastics

What is Xpovio, 40 mg once a week?

The Xpovio dosage of 40 mg twice-weekly is combined with bortezomib or dexamethasone to treat multiple myeloma in adults.

Xpovio 40 mg once-weekly is also taken by adults to treat specific kinds of diffuse B-cell lymphoma.

Xpovio 40 mg twice-weekly is administered after other drugs have failed or ended their effectiveness.

Xpovio 40 mg once a week has been authorised by the US Food and Drug Administration (FDA) on an "accelerated" basis. In studies conducted in clinical trials, certain patients did respond positively to Xpovio 40 mg every week; however, further research is required.

The Xpovio 40 mg dose once a week can be prescribed for other purposes that are not covered in this guideline.

Side effects of Xpovio, 40 mg

See a doctor immediately. Get medical attention immediately if you notice warning signs of an allergic response, such as symptoms of hives, difficulty breathing, and swelling of your lips, face, and tongue.

The Xpovio 40 mg dose once per week could cause fatal or serious adverse reactions. Certain side effects might not be noticed until after you have been taking the medicine for a few days or weeks.

Xpovio 40 mg every week may result in serious adverse side effects. Contact your physician immediately if you suffer from:

  • Blurred vision blurred vision, tunnel vision, eye pain, or seeing halos of light sources;
  • Severe ongoing nausea, vomiting, or diarrhoea;
  • Lack of appetite that stops you from eating and leads to the loss of weight;
  • Dizziness, confusion, fainting, or changes in mental state;
  • Signs that are indicative of sepsis symptoms of sepsis the symptoms of sepsis are fever and chills. Extreme fatigue, rapid heartbeats, quick breathing, and feeling sick;
  • Indications of symptoms of fever colds Signs of infection include chills, fever signs, a cough with mucus, throat and mouth ulcers, feeling tired, a sensation of tingling or pain in the rash on the other part of the body, or
  • Low sodium levels low sodium levels, headaches, and slurred speech. Nausea, severe weakness, and loss of coordination. Feeling unstable.

Your treatment could be delayed or removed if you suffer from specific adverse consequences.

Common side effects of Xpovio 40 mg once a week could be:

  • Dual vision and blurred vision the sensitivity to light and glare
  • Tiredness;
  • Tingling, numbness, and burning or numbness in your feet or hands;
  • Anaemia, bleeding, bruising, or bleeding;
  • Higher blood sugar levels
  • Infections, fever, cold, or flu symptoms;
  • Variations in mineral and sodium levels;
  • Irregular kidney function or liver tests;
  • Nausea, nausea, vomiting, loss of appetite
  • Diarrhoea, constipation;
  • Weight loss;

This is not a comprehensive list of all the side effects. Other side effects could occur. Consult your physician to seek medical advice on the effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


You could contract infections more frequently, and even severe or fatal illnesses. Call your doctor when you experience fever or chills, flu symptoms, mouth ulcers, coughing, or breathing problems.Xpovio 40 mg every week may cause low platelet counts in your blood. Contact your physician immediately in the event of unusual bruising or bleeding.

Before you take this drug

Inform your doctor if you have ever suffered from:

  • Cataracts;
  • Bleeding issues as well as
  • Active or recent infections.

It is possible that you will need to take an ultrasound test that is negative prior to beginning this treatment.

Men and women who are taking Xpovio 40 mg once a week should make use of effective birth control to avoid pregnancies. Xpovio 40 mg every week can harm an unborn child if a father or mother uses this medicine.Use contraceptives for at least one week after the last dose. Contact your doctor immediately when you become pregnant when both the mother and father are taking Xpovio 40 mg every week.

This medication can affect fertility (the ability to have children) in both males and women. But it is crucial to take birth control in order to avoid pregnancy since Xpovio 40 mg taken once a week can cause harm to a baby who is not born.Don't breastfeed while taking this medicine or for at least one week following the last dose.Not recommended for use by anyone less than 18 years of age.

How to take Xpovio 40 mg

The doctor will run tests to determine if Xpovio 40 mg a day is the best treatment for your needs.Follow the directions on the prescription label and review all medication guides and instruction sheets. The doctor might alter the dosage. Make sure you take the medication exactly as prescribed.

Xpovio 40 mg taken once a week is typically taken on specific days, usually once or twice a week. Follow the instructions of your physician carefully regarding the best time and method to take this medication with dexamethasone or bortezomib.Your physician will decide the time frame for treatment with Xpovio 40 mg once a week and dexamethasone.Consume Xpovio 40 mg every week with a full cup of fluid. Take the tablet whole; don't crush, chew, or tear it.If you experience vomiting shortly after you have taken Xpovio 40 mg twice a week, don't take a second dose. The next dose should be taken as scheduled.

There are additional medications to treat nausea, vomiting, infections, or nausea. Take these medications for the duration your physician prescribes.There is a chance that you will contract infections more often, or even fatal or serious infections. You'll require frequent medical tests. It is possible to require transfusions if your blood platelets become too low.The sodium levels in your blood are required to be checked. If they are way too low, your physician might recommend tablets of salt or intravenous (IV) fluids to prevent your body from becoming dehydrated.Take plenty of fluids to avoid dehydration. Also, take in enough calories to stop losing weight.

The Xpovio 40 mg dose once per week may alter your appetite or capacity to consume food. The weight of your body will be measured prior to and during the treatment in order to ensure that you do not lose weight when taking this medication.Make sure the tablet is kept at a the room temperature away from humidity and heat. Store every Xpovio 40 mg tablet once per week inside the pack of blisters until the point of taking your dosage.

What happens if I miss a dose?

Do not miss the missed dose, and take your next dose according to the time you normally take it.Take two doses in one go.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Avoid driving or engaging in hazardous activities until you are aware of how Xpovio 40 mg taken once a week will affect your health. Your reaction could be affected.

Interaction with other drugs

Other medications can impact Xpovio 40 mg once a week, such as prescription and over-the-counter medicine, vitamins, and herbal supplements. Inform your physician about any other medications you are taking.




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