The Web Health



Generic Name: Vortioxetine [VOR-tye-OXe-teen] [VOR-tyeOXe-teen
Names of Brands: Trintellix, Brintellix, Brintellix (vortioxetine)
Dosage Format: (10 mg, 20 mg, 5 mg) Oral tablet
The Class of Drug: Miscellaneous antidepressants

Which is Vortioxetine?

Vortioxetine, an antidepressant, is prescribed in the treatment of major depression disorders in adults.Vortioxetine can also be employed for other purposes that are not covered in this guideline.

Side effects of Vortioxetine

Contact a medical professional immediately. If you are experiencing symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, and tongue,

Inform your doctor about any new or worsening symptoms, for example, a change in your mood or behavior, anxiety, panic attacks, trouble sleeping, or if you feel angry, irritable, or impulsive, aggressive, Active, unrestful (mentally and physically) or depressed. This is especially true if you contemplating suicide or taking care of yourself.

Vortioxetine may cause serious side effects. Contact your doctor immediately. If you suffer from:

  • Racing thoughts, less desire to sleep, unusual risk-taking behavior or feelings of extreme joy or sadness, and being more sociable than usual
  • Vision changes, eye pain, eye redness, or swelling;
  • Simple bleeding, unusual bruising, coughing up blood,
  • Low sodium levels (which may be more prevalent in older people) may cause confusion, hallucinations, memory problems, or slurred speech. weakening, feeling unstable.

Get immediate medical attention. If you experience signs that suggest serotonin syndrome, which include hallucinations, agitation, sweating or shivering, an increase in heart rate, muscle stiffness and twitching, loss of coordination, nausea, vomiting, or diarrhea,

Common adverse effects of vortioxetine could be:

  • Nausea;
  • Constipation
  • Vomiting.

This is not a comprehensive list of all the side effects. Others could happen. Consult your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


A few young people may have thoughts of suicide while using an antidepressant. Be attentive to changes in your mood or symptoms. Inform your doctor if you notice any changes or worsening symptoms.

Before you Take this Drug

It is not recommended to use vortioxetine if you have an allergy to it.Do not take vortioxetine if you've used an MAO inhibitor in the last 14 days. A potentially dangerous interaction with a drug could happen. MAO inhibitors include isocarboxazid, linezolid, Methylene Blue injection, phenelzine, and tranylcypromine, as well as others.When you stop taking vortioxetine, you must wait at least 21 days before starting the MAO inhibitor.

Consult your doctor if you are also taking stimulant medicines, opioid medication, herbal products, or medicines to treat depression, mental illness, Parkinson's disease, migraine headaches, severe infections, or the prevention of vomiting and nausea. Vortioxetine's interaction could result in a serious illness known as serotonin syndrome.

Speak to your doctor if you are ever diagnosed with:

  • Bipolar disorder (manic depression) as well as a past history of substance use or suicidal ideas;
  • Glaucoma;
  • Seizures or epilepsy;
  • Bleeding issues as well as
  • Low levels of sodium within your blood.

Some young people might be tempted to commit suicide following the first time they took an antidepressant. Your doctor should monitor your progress on a regular basis. Your family members and other caregivers should be aware of changes in your symptoms or mood.Not allowed to be used by anyone under the age of 18.

Pregnancy medications such as vortioxetine during the last three months of pregnancy could result in problems for the newborn, like withdrawal symptoms, lung issues, or other problems in the baby. However, stopping the drug is not always safe for you. Do not begin or stop taking vortioxetine unless you consult your physician.

Consult a physician to determine whether it is safe to breastfeed when using vortioxetine.

How to Take Vortioxetine?

Follow the directions on the prescription label and review all medication guides and instruction sheets. Your doctor may alter your dosage. Follow the medication exactly as prescribed.It can be taken without or with food.

There are withdrawal symptoms that you may experience in the event that you suddenly stop using vortioxetine. Talk to your doctor prior to taking the medication off.Place it in a cool, dry place far from heat and moisture.

Details on Dosage

Usual Adult Dose for Depression:

Initial dosage: 10 mg orally every day, once
Maintenance dosage: 5–20 mg once orally every day.
Maximum dose: 20 mg/day
Patients should be tested to rule out bipolar disorders, hypomania, and hypomania prior to initiating treatment.
Patients who are not able to tolerate doses higher than 5 mg may be kept on 5 mg taken orally every day.
Use: Treatment for major depression (MDD)

Usual Adult Dose for Major Depressive Disorder:

Initial dosage: 10 mg orally every day, once
Maintenance dosage: 5 to 20 mg taken orally, once a day.
Maximum dose: 20 mg/day
Patients must be screened for bipolar disorder, manic depression, and hypomania prior to beginning treatment.
Patients who cannot take higher doses can be treated with 5 mg daily.
Treatment for major depression (MDD)

What Happens If I Miss a Dose?

You should take the medication as quickly as you are able, but do not take any missed doses if you are close to the time of the next dose. Don't take two doses at once.

What Happens If I Overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What Should be Avoided?

Avoid driving or engaging in hazardous activities until you are aware of how vortioxetine affects your body. The way you react could be affected.

Interaction with Other Drugs

Discuss with your doctor the medicines you are currently taking. Numerous drugs can alter the effects of vortioxetine, particularly:

  • Any other antidepressant or similar;
  • Buspirone;
  • Fentanyl, tramadol;
  • lithium;
  • St. John's wort tryptophan (sometimes known as L-tryptophan);
  • The blood thinners (warfarin, coumadin, and Jantoven);
  • Diuretic or "water pill";
  • Migraine medication (triptans);
  • The NSAIDs (nonsteroidal anti-inflammatory drugs)—aspirin, Ibuprofen (Advil, Motrin), naproxen (Aleve), as well as celecoxib, diclofenac, indomethacin, meloxicam, and many others—
  • Seizure medicine—carbamazepine, phenytoin.

This list isn't complete, and other drugs could interfere with vortioxetine. This includes over-the-counter and prescription medications, vitamins, and herbal supplements. There are many possible interactions between drugs. are listed here.