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Ilaris

Name of the generic: canakinumab canakinumab KAN-a-KIN-ue -mab [ KAN-aKIN-ue-mab
Drug class: interleukin inhibitors

What is Ilaris?

Ilaris is a monoclonal antibody that blocks specific proteins within the body that may cause inflammation and other immune reactions. Canakinumab can be used to treat specific types of cancer that are characterized by periodic fever. often referred to as auto-inflammatory syndromes.

The syndromes of periodic fever are extremely rare and are often due to mutations in specific genes. These are usually genes that produce an enzyme or a specific protein within the body. Patients suffering from a condition known as periodic fever experience instances of fever and inflammation without any other cause, such as an infection or virus.

Ilaris uses it to manage these periodic fever syndromes in children and adults who are at or above 4 years old.

  • Cryopyrin-Associated Periodic Disorders, such as Familial Cold Autoinflammatory Symptoms as well as Muckle-Wells Syndrome

  • Tumor Necrosis Factor Receptor-Associated Periodic Syndrome

  • Hyperimmunoglobulin D Syndrome, also called Mevalonate Kinase Deficiency

  • Familial Mediterranean Fever (FMF)

Ilaris can also be employed to manage Still's disease, which includes adult-onset Still's disorder as well as systemic juvenile idiopathic arthritis in children that are less than two years old.

Warnings

Sometimes fatal infections can occur while taking Ilaris. Get your doctor's attention immediately if you experience symptoms of infection like fever, chills, sweating, fatigue, coughing, breathlessness, skin sores, hot or sensitive areas on your body, vomiting, stomach pain, and losing weight

Prior to use this drug 

Ilaris is not recommended for use if you have an allergy to canakinumab. Inform your doctor whether you've ever suffered from tuberculosis, if someone within your family is suffering from tuberculosis, or if you've recently been to an area where tuberculosis can be found.

To ensure that Ilaris is suitable for you, inform your doctor if you've previously had:

  • An ongoing or chronic infection;

  • Low white blood cell count;

  • A weak immune system

  • HIV, Hepatitis B, or Hepatitis C;

  • An underlying past of recurring infections or

  • If you recently received or are due to be given any vaccination,

Check that you are up-to-date on all vaccinations prior to when you start treatments with Ilaris.

The treatment with Ilaris can increase the chances of getting cancer. Discuss with your physician the risks you face. Inform your doctor if you are pregnant or planning to be pregnant.

If you're using Ilaris when you're pregnant, be sure that the doctor taking care of your baby understands that you were using the medication during your pregnancy. Being exposed to Ilaris during pregnancy can affect the baby's vaccination schedule in the first year of his life. mIt is not recommended to breastfeed while taking this medication. Consult your physician regarding any risks.

How to take Ilaris?

Ilaris is injected beneath the skin. The healthcare professional will give you the injection. Before starting treatment with Ilaris Your doctor will conduct tests to ensure that you don't have tuberculosis or any other infections. Ilaris is generally prescribed every 4–8 weeks, depending on the illness being addressed. Follow your doctor's prescriptions. Inform your doctor if you notice any weight changes. Canakinumab doses are determined by weight (especially for teenagers and children), and any change can affect the dose. Ilaris may affect your immune system. Your blood might require frequent testing.

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make an appointment to receive the Ilaris injection.

What happens if I overdose?

Because this medication is administered by a medical expert in a medical environment, it is highly unlikely for an overdose to occur.

What should be avoided?

Beware of those who are sick or suffer from infections. Contact your doctor right away when you begin to show symptoms of an infection.

Do not get any "live" vaccines while using Ilaris. The vaccine might not function at all at this point and might not completely safeguard you from illness. The live vaccines are measles, rubella, and mumps (MMR), as well as rotavirus, yellow fever, typhoid, varicella (chickenpox), zoster (shingles), and the nasal influenza (flu) vaccine.

Side effects of Ilaris

Seek medical attention immediately. If you are experiencing symptoms that indicate an allergy reaction, Ilaris: hives; nausea and difficulty taking a swallow; dizziness; rapid or pounding heartbeats; difficulty breathing; or swelling of your lips, face, or tongue.

Sometimes fatal infections can occur when you are treated with Ilaris. Contact your physician immediately if you notice symptoms of infection, such as:

  • The fever lasts for more than 3 days and causes sweating and chills.

  • Heat, sores, or pain anywhere on your body.

  • Stomach pain, diarrhea, weight loss;

  • Continuous cough, shortness of breath;

  • Chest pain; chest pain; coughing up mucus or blood;

  • Burning or pain after you urinate;

  • Redness on one area of your body

  • Warmth, redness, or swelling under your skin; or

  • Influenza symptoms include feeling very tired.

Common Ilaris side effects could include:

  • Flu or cold symptoms (runny nose, cough, sore throat, and body pains);

  • Nausea, vo

    miting

    , diarrhea, and stomach pain;

  • Painful urination;

  • Dizziness, spinning sensation;

  • Headache;

  • Weight gain or

  • Itching and redness, swelling, or a feeling of warmth around the site where the medicine was in the area of injection

     

This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs 

It is sometimes not safe to take certain medicines together. Certain drugs may affect the blood levels of other medications you are taking, which could cause more side effects or make the medication less effective.

Inform your doctor about any other medications you take, including:

  • Anakinra;

  • Adalimumab, certolizumab, golimumab, and infliximab;

  • Etanercept, rilonacept;

  • Warfarin 

  • Other medications that weaken the immune system's functions, including steroids, chemotherapy, and other medications that stop rejection of organ transplants.

     

This list isn't comprehensive. Other drugs can interact with canakinumab, such as prescription and over-the-counter medicines, vitamins, and herbal supplements. Some interactions with drugs are not listed here. are listed here.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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