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What is Vagifem?
Vagifem vaginal implants contain estradiol, an endocrine form of estrogen. Estrogen is a female sexual hormone that regulates various functions in the body.vagifem can be used following menopausal changes to help treat menopausal manifestations (such as burning, dryness, and irritation) within the vagina and in the area around it.
Vagifem is a small round, white bi-convex, film-coated vaginal insert with 10 mg of estradiol. Each vaginal insert measures 6 millimeters in diameter and is dispensed using an applicator that is disposable.
Warnings
You should not take vagifem for those who suffer from vaginal bleeding that is not diagnosed, liver disease, a bleeding disorder, or if you are scheduled to undergo major surgery or if you've ever experienced a heart attack or stroke, blood clots, or cancers of the uterus, cervix, breast, or vagina.
Don't use vagifem if you are expecting.estradiol could increase your chance of developing an illness that could result in cancer of the uterus. If you notice any bleeding from your vagina, that seems unusual.
The use of vagifem increases the chance of developing blood clots, heart attacks, strokes, and cancers that affect the uterus, breast, or ovaries. Vagifem should not be used to stop stroke, heart disease, or alzheimer's disease.
Before you take this drug
You shouldn't use vagifem in the event that you are allergic to estradiol, or you are:
- Abnormal vaginal bleeding that isn't being examined by the doctor;
- Liver disease;
- An occurrence of stroke, heart attack, or blood clots
- An increased chance of developing blood clots because of an issue with the heart or hereditary blood disorder
- A history of cancer related to hormones is also known as cancer of the uterus, cervix, breast, or vagina.
Do not take vagifem when you are expecting. Tell your doctor immediately if you find yourself pregnant while receiving treatment.
Vagifem vaginal implants can increase the risk of stroke, blood clots, and heart attacks. You're more at risk if you suffer from hypertension and diabetes, excessive cholesterol, or if you're overweight or smoke.
Vagifem is not a suitable choice to treat stroke, heart disease, or dementia. It could actually increase the risk of developing these illnesses.
To ensure that vagifem is suitable for you, inform your doctor if:
- Heart disease;
- Liver issues liver problems, and jaundice resulted from pregnancy or the use of hormonal medications;
- Kidney disease;
- Gallbladder disorder;
- Asthma;
- Epilepsy or any other seizures;
- Migraines;
- Lupus;
- Endometriosis or uterine fibroid tumors;
- The hereditary angioedema;
- Porphyria (a genetic disorder of enzymes that can cause symptoms in the nervous system, skin, or nerves);
- A thyroid disorder
- Low or high levels of calcium in your blood.
The use of estradiol can increase the risk of cancer of the uterus, breast, or ovaries. Discuss the possibility with your physician.estradiol is known to reduce the production of breast milk. Consult your physician if you are breastfeeding.
Similar/related drugs
Estradiol, premarin, estrace, and prempro
How to take Vagifem?
Utilize vagifem as directed by your physician. Follow the directions on the label of your prescription and also read the medication guide or instructions sheets.
Estradiol could increase your chances of developing a condition that could cause uterine cancer. Your doctor might prescribe progesterone to reduce the risk. Consult your physician immediately if you experience abnormal vaginal bleeding.cleanse your hands prior to and after you insert vagifem.
Each tablet is delivered in a single-use, disposable applicator. Dispose of the tablet applicator after a single use.
Instructions for the use of the applicator
- Take a single applicator off.
- Remove the plastic wrap, and then remove the applicator from the wrap. If, after opening the package, you find that the insert has slipped through the applicator but isn't completely out of the packaging, then carefully place it back in the applicator to be inserted. Be sure to keep your hands clean and dry when manipulating the insert.
- Make sure to hold the applicator in a position where the fingers on one hand can push the plunger on the applicator.
- Then, choose the ideal place for vaginal inserting of vagifem vaginal inserts that is most comfortable for you, e.g., sitting or reclining.
- With another hand, you can guide the applicator slowly and gently into the vein. If, prior to inserting the insert, it is pushed off the applicator, discard the applicator, insert it out, and get an applicator with a new insert.
- The applicator must be placed (without pressing) as close to your vagina as is feasible, or until 50% of your applicator has been inserted into the vagina, or less.
- After the applicator filled with inserts is placed in the insertion area, gently press the plunger until it is completely removed. The insert will be ejected into your vagina, which will then dissolve over a period of time.
- After pressing on the plunger to release it, slowly take off the applicator and discard it in the same way you would dispose of an applicator made of plastic. The applicator will be of no longer use and must be removed from the trash in a proper manner. Insertion can be performed at any time during the day. It is recommended to do it at the same time every day for all vagifem vaginal implants. If you have questions, it is advisable to speak to your physician or pharmacist.
Your physician should monitor your performance every month to determine if you are able to continue with this treatment. Check any lumps in your breasts on a regular basis. You should also have an annual mammogram when you are taking vagifem.
If you require major surgery or are being placed on bedrest for long periods of time, you may need to cease taking vagifem for a short period of time. Any surgeon or doctor who cares for you must be aware that you're taking vagifem.
Keep vagifem in a cool, dry place, away from heat and moisture.
What happens if i miss the dose?
Take the medication as quickly as you are able, but do not miss any missed doses if it's nearing time to take the next dose. Do not take two doses at once.
What happens if i overdose?
Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.
What should be avoided?
Do not smoke. Smoking can significantly increase the chances of having blood clots, strokes, or heart attacks while you are using vagifem.
Beware of other vaginal products that aren't approved by the advice of your doctor.grapefruit could interact with estradiol, leading to undesirable negative consequences. Beware of using grapefruit-related products.
Side effects of vagifem
Contact a medical professional immediately if you notice any of the following symptoms or warnings of an allergic reaction: hives, breathing difficulties, or swelling of your lips, face, and throat.
Contact your doctor immediately. If you are suffering from:
- Heart attack signs heart attack symptoms: chest pain, pressure, the pain spreading into your shoulder or jaw, nausea, sweating, or vomiting;
- Symptoms of stroke: sudden weakness or numbness (especially on the opposite part of your body) and sudden extreme headache or slurred speech; difficulties with balance or vision;
- Symptoms of the presence of a blood clot: sudden loss of vision and chest pain that is stabbing, feeling breathless, and coughing up blood. Discomfort or warmth in both legs or one;
- Tenderness or swelling in your stomach;
- Jaundice (yellowing of the eyes or skin);
- Memory issues or confusion, abnormal behavior;
- Abnormal urinary bleeding or pelvic discomfort
- An unidentified bump in the breast
- High levels of calcium present in the blood cause nausea, constipation, more frequent urination or thirst, muscles, bones, discomfort, and fatigue.
Common side effects of vagifem include:
- Nausea, vomiting, bloating, and stomach cramps;
- Headache;
- Swelling of your feet or hands or feet, weight gain
- Painful breasts
- Vaginal discharge or itching or discharge from your vagina; change in menstrual cycles; breakthrough bleeding
This isn't an exhaustive list of all the side effects. Other side effects could be present. Contact your doctor to seek medical advice on the effects. You may report any adverse reactions to the fda at 1-800-fda-1088.
Interaction with other drugs
There are times when it's not recommended to take certain medicines in combination. Certain medications can alter the blood levels and the other drugs that you take, which can create side effects or render the medication less effective.
Numerous drugs may interact with estradiol. This includes prescription and over-the-counter drugs, vitamins, and herbal products. Not all interactions are included in this list. Discuss with your physician all the medications you are currently taking and any medication you begin or stop taking.