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Generical name: mafenide topical Topical MAF-en-ide MAF-en-ide
Class of drugs: topical antibiotics

The Sulfamylon brand name has been removed in the U.S. If generic versions of the product are accepted by the FDA, There may be substitutes that are generic.

What is Mafenide?

Mafenide is an antibiotic that fights the presence of bacteria in the body. Sulfamylon (for the skin) is used to reduce infections in severe burns. Mafenide is also employed for purposes that aren't mentioned in this guideline.

Side effects of Mafenide

Seek medical attention immediately. If you notice one of the following symptoms of an allergic reaction: difficulty breathing or swelling of your lips, face, and tongue.

Contact your caregivers right away if you are suffering from:

  • Skin that is pale or yellow, dark urine, fever, weakness, or confusion;
  • Rapid breathing;
  • Skin and bruising, or extreme numbness, tingling, muscle weakness, pain, or
  • Extreme skin irritations when the medication is applied.=

Common adverse effects of sulfamylon include:

  • Redness, rash, blistering, and itching of the treated skin
  • Burning or pain in the treated skin or
  • White or "pruned" appearance of the skin (caused by putting dressings for wounds on for a long period of time).

This is not an all-inclusive list of possible side effects, and others could happen. Consult your physician for advice on medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Related drugs

lidocaine topical, vancomycin, gentamicin, tobramycin, Silvadene, and benzocaine topical


Follow all the instructions on the label of your medicine and on the label of your package. Inform all of your healthcare professionals about all your medical conditions, allergies, and medicines.

Before taking this medicine, make sure you know the following:

You shouldn't use sulfamylon if you're intolerant to mafenide.

To ensure that Sulfamylon is appropriate for you, inform your doctor if you suffer from:

  • kidney disease;
  • a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency;
  • asthma, sulfite allergy, or
  • If you are allergic to sulfa-containing drugs.

FDA pregnancy classification C It is not clear whether sulfamylon can harm a baby who is not yet born. Consult your physician if you are expecting or planning to get pregnant while taking this medication. It isn't known if mafenide's topical metabolites are absorbed through breast milk or whether they may harm a nursing infant. It is advised not to breastfeed when using this medication.

How to take Mafenide?

The doctor who prescribes you the appropriate dosage and kind of mafenide you should use You can receive this medication in a burn unit.

Mafenide cream is typically applied to the burn at least once or twice per day. The wound should be covered with this medication throughout treatment.

Mafenide powder is typically mixed with a solution of saline and applied to gauze dressings with a syringe or an irrigation tube. Mafenide is typically applied a few times a day to keep the bandaging moist.

What happens If I miss a dose?

Because you'll be receiving sulfamylon in a clinical setting, you're not likely to miss the dose.

What happens if I overdose?

Since sulfamylon can be administered by a medical professional in a medical setting, an overdose is not likely to occur.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on foods, beverages, or activities.

Interaction with other drugs

It is unlikely that other drugs you consume by mouth or inject will have any impact on the topically applied mafenide. However, many drugs interact with each other. Inform your health care providers about the medications you take, such as prescription and over-the-counter medications, vitamins, and herbal products.