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The Generic Name: Macimorelin [MA-si-moe-REL in].
Name of the Brand:
Dosage Format: Oral granule for reconstitution (60 mg).
Drug Class: Growth hormones.

What is Macimorelin?

Macimorelin is a stimulant that triggers an increase in the production of growth hormone (GH) within the body. Macimorelin is a component of an examination that is used to test the growth hormone (GH). Macimorelin can also be used for reasons not mentioned in this medication guide.

Side effects of Macimorelin

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, and tongue. Macimorelin may cause serious side effects. Consult your medicare immediately in the event that you experience:

  • You feel lightheaded, as if you're passing out.
  • Heartbeats that are slow.
  • Breathlessness.
  • Rapid or pounding heartbeats, getting your chest to flutter, breathlessness, and a sudden feeling of dizziness (like you're going to faint).

Common Macimorelin-related side effects could include:

  • Headache, dizziness.
  • Hunger, nausea, and diarrhea.
  • More sweating and feeling hot.
  • Changes in your sense of taste.
  • Symptoms like stuffy sinuses, nasal discomfort, and a sore throat.

TThis is not an exhaustive list of probable adverse effects; more may occur. Consult your physician to seek medical advice on the effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


Follow the directions on your prescription label and the package. Be sure to inform your healthcare professionals about your medical issues, allergies, and the medicines you are taking.

Before you take this drug

Inform your doctor about any medications you are taking. Certain medications taken prior to your GH test can result in false results. It is not recommended to treat with macimorelin if you are sensitive to it.

Speak to your doctor if you have ever suffered from:

  • A hormonal disorder.
  • A thyroid disorder.
  • Hypothalamus disorders.

Discuss with your doctor if you are nursing or pregnant.

You should stop using any growth hormone medication at least one week before your GH test date. You should be fasting before taking macimorelin. Do not eat or drink anything other than water for a minimum of 8 hours prior to your GH test. Macimorelin is available as a single dose. The healthcare professional will mix macimorelin in an alcoholic drink that you drink within 30 seconds. When you drink macimorelin, a blood sample will be taken 30 minutes later, 45 minutes later, 60 minutes later, and 90 minutes later. This will help your physician identify the severity of your illness.

Details on dosage

Usual Adult Dose for Growth Hormone Reserve Test:

0.5 mg/kg oral after fasting for at least 8 hours.
Stop treatment with powerful CYP450 3A4 stimulants, growth hormones, and other drugs that affect the release of growth hormones for a sufficient amount of time prior to taking this medication.
It is recommended to replace any hormone deficiencies prior to taking the medication.
Safety and diagnostic efficiency are not established for patients who have an index of body mass greater than 40 kg/m2.
Use to diagnose an adult deficiency in growth hormone.

What happens if I miss a dose?

Macimorelin can be used in one dose and doesn't have a day-to-day dosing schedule.

What happens if I overdose?

Since macimorelin can only be administered by a health specialist in a medical setting, the risk of overdose is less likely to occur.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or any activity.

Interaction with other drugs

Inform your doctor about any other medications you take. There is a chance that you will get false results when you take certain medicines prior to the GH test. It is possible that you need to stop taking various medications for a specific amount of time prior to the date you can take macimorelin. Macimorelin may cause a serious heart issue. The risk is higher if you take various other drugs to treat asthma, infections, and heart issues. high blood pressure, depression, mental illness, malaria, cancer, or HIV. Macimorelin is a drug that can be affected by a variety of drugs. This includes prescription as well as over-the-counter drugs, vitamins, and herbal supplements. The interactions between these products are not mentioned here. Inform your doctor of all the medications you are currently taking and any medications you begin or stop taking.