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Empagliflozin and Metformin

Generic name: empagliflozin and metformin [EM-pa-gli-FLOE-zin-and-met-FOR-min]

Brand names: Synjardy, Synjardy XR
Forms of dosage: oral tablet (12.5 mg-1000 mg; 12.5 mg-500 mg; 5 mg-1000 mg 5-500 mg); oral tablet longer release (10 mg-1000 mg; 12.5 mg-1000 mg; 25 mg-1000 mg 5-1000 mg)
Classification of drugs: antidiabetic combinations

What is Empagliflozin and Metformin?

Empagliflozin, as well as metformin, is a combination drug combined with exercise and diet to increase blood sugar control in adult patients with diabetes mellitus type 2. diabetes mellitus.Metformin and empagliflozin can also be used to decrease the risk of death due to stroke, heart attack, or heart failure among adults who suffer from type 2 diabetes and have heart disease.Metformin and empagliflozin are not used to treat type 1 diabetes.Metformin and empagliflozin can also be used to treat conditions not covered in this medication guide.

Side effects of Empagliflozin and Metformin

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, like hives, difficulty swallowing, breathing difficulties, and swelling of your lips, face, and tongue,You should seek medical attention immediately if you notice symptoms or warning signs of an underlying genital disease (penis or vagina): burning, itching, and odor; painful bleeding; tenderness; swelling or redness in the rectal or genital area; fever; not feeling well. The symptoms could worsen quickly.Stop taking this medication immediately and reach out to your physician as soon as possible.If you suffer from:

  • An overwhelming feeling of lightheadedness;
  • Dehydration—dizziness, confusion, feeling very thirsty, less urination;
  • Ketoacidosis (too much acid in the blood) ketoacidosis (too much acid in the blood) vomiting, vomiting, stomach anxiety, confusion, pain, tiredness, or trouble breathing;
  • Acidosis due to lactic--unusual muscular pain, trouble breathing, nausea, stomach pain, irregular heartbeat, dizziness, and sensation of being cold or feeling extremely fatigued or weak; or
  • Indications of signs of urinary tract infections: pain or burning sensation when you go to the bathroom or urinate, blood in the urine, pain in your pelvis or in your back.

Certain adverse reactions are more likely to occur in older adults.

Common adverse effects of empagliflozin or metformin can include:

  • Lower blood sugar;
  • Indigestion, stomach pain, gas, nausea, vomiting, diarrhea;
  • A bladder infection;
  • Women with yeast-related infections (vaginal bleeding or itching);
  • Headache or weakness
  • Runny or stuffy nostrils or a stuffy sore throat

This list isn't an exhaustive one of all possible side effects. Others could happen. Contact your physician for advice regarding medical adverse effects. Please report any adverse side effects directly to the FDA at 1-800-FDA-1088.

Similar or related drugs

Ozempic, Mounjaro, metformin, Trulicity, Lantus, Victoza, and Levemir


Stop taking metformin and empagliflozin and contact your doctor anytime if you show symptoms of a serious adverse effect like severe stomach discomfort (which may extend over your entire back) or vomiting, tiredness, or difficulty breathing.Consult your physician if you have a stomach ache or diarrhea. Also, tell your doctor that you have a less nutritious diet or drink than normal.Seek medical attention immediately. If you experience indicators of acidosis, like abnormal muscle pain, difficulty breathing, or irregular heartbeats, as well as if you're feeling weak,This medicine may cause serious infections in the vagina or penis. Get medical help immediately if you notice irritation, burning, odor, discharge, discomfort, tenderness, swelling in the rectal or genital area, fever, or do not feel well.

Before you take this drug

It is not recommended to take this medication if you have an allergy to metformin or empagliflozin or if you suffer from

  • Severely kidney-related disease (or if you're taking dialysis).
  • Metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you are required to undergo surgical procedures or any other scan, such as x-rays or CT scans with dyes that are injected into your veins, then you might have to temporarily discontinue using this medication. Make sure that your healthcare providers know beforehand that you are taking empagliflozin or metformin.Speak to your doctor if you have ever suffered from:

  • Kidney or liver disease
  • An infection of the bladder or urinary tract problems;
  • Congestive heart failure, stroke, or heart attack;
  • A genital disease (penis or vagina);
  • Issues with your pancreas that may require surgery
  • If you're on an eating plan with a low salt intake,
  • If you're 65 or older,

It is possible to get the condition known as lactic acidosis. It is an extremely dangerous accumulation of lactic acid within your blood. Consult your physician about the chance of developingFollow the instructions of your physician regarding the use of this medication when you are pregnant or are planning to be pregnant. Controlling diabetes is crucial during pregnancy.You shouldn't make use of metformin and empagliflozin in the third or second trimester of pregnancy.Metformin can stimulate ovulation in women who are premenopausal and could increase the risk of unintentional pregnancy. Consult your doctor regarding your risks.Do not breastfeed.Not allowed to be used by anyone under 18.

How to take Empagliflozin and Metformin?

Follow all the instructions on your prescription label, and go through all medication guides or instructions sheets. The doctor might change the dosage. Make sure you take the medicine exactly as prescribed.Eat meals.Suck the extended-release tablets in their entirety and don't crush or chew on them. Break, break, or dissolve it. Inform your physician if you encounter difficulty taking the tablet.Your blood sugar level will need to be regularly checked, and you might be required to check the amount of ketones present in your urine. The ketoacidosis that is caused by empagliflozin is life-threatening (too much acid in your blood). Even if your blood sugar level is normal, you should consult your doctor if a urine test indicates that you have elevated ketones in your urine.Blood sugar levels can be affected by illness, stress, surgical procedures, alcohol consumption, and eating infrequently.Low levels of blood sugar (hypoglycemia) can cause you to feel extremely thirsty, dizzy, upset, or even unstable. To speedily manage hypoglycemia, consume or drink crackers, hard candy, raisins, fruit juice, and non-diet drinks. Your doctor might prescribe the glucagon injections in the event of severe hypoglycemia.

You could become dehydrated as a result of a long-term illness. Contact your physician if you are suffering from vomiting or diarrhea or if you consume less food or drink than normal.Speak to your doctor if you are planning a procedure.Metformin and empagliflozin may affect the results of certain tests. Inform any physician who treats you that you're taking metformin and empagliflozin.Your doctor might suggest that you take an additional dose of vitamin B12 when you take metformin or empagliflozin. Only take the vitamin B12 that your doctor has recommended.The treatment you receive could also include exercise, diet, weight control, or specific medical treatment.Keep it at room temperature, free of heat and moisture.

What happens if I miss the dose?

You should take the medication (with food) immediately if you are able, but don't take your missed dose in case it's nearing the time to take the next dose.Do not take two doses at the same time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Helpline at 1-800-222-1222.An overdose may cause lactic acidosis. Signs could include a rash of muscle pain or breathing issues, irregular heartbeats, or feeling weak.

What should be avoided?

Beware of drinking alcohol. It could increase your chances of developing lactic acidosis.Stay slow when rising from lying or sitting positions. Do not rush up too quickly from either of them.You could be dizzy.

Interaction with other drug

Other medications can alter or enhance the effects of empagliflozin or metformin on lowering blood sugar. Discuss with your doctor all the medicines you are currently taking and any that you decide to start or stop taking, particularly:

  • Insulin or any other oral diabetes medication;
  • Diuretic, also known as a "water pill."

This list isn't exhaustive. Other medications can affect metformin and empagliflozin.These include prescription and over-the-counter medicines, vitamins, and herbal products.There are many possible interactions between drugs that are listed here.



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