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Generic name: lidocaine and tetracaine topical [LYE-doe-kane-and-TET-ra-kane-TOP-i-kal]
The brand names are: Pliaglis, Synera
The class of drug: topical anesthetics

What is Pliaglis?

Pliaglis (for application on the surface of the skin) is a combination medication that is used to numb a portion of your face. This may help reduce discomfort when performing certain procedures, like the skin biopsy or minimal surgery, the skin surgery, the placement into one's IV needle, or other needle-stick procedures.

Pliaglis can also be used to reduce pain in the skin for small cosmetic procedures like a botox injection or laser treatment. It can also be used for the removal of tattoos. Pliaglis is also employed for other purposes that are not covered in this medication guide.

Side effects of Pliaglis

  • Extreme burning, stinging, or any other irritations when the medicine was injected;
  • Abrupt dizziness, or dizziness following the time the medication is used;
  • Light, gray, or blue-colored skin;
  • Headache, quick pulses, the feeling of breathing becoming short;
  • Tiredness or feeling as if you're about to pass out;
  • Blurred vision, sounds in your ear, or
  • Bizarre sensations that come from being cold or hot. Cool.

Common adverse effects are:

  • Skin redness;
  • Skin swelling skin swelling
  • Change in the color of the skin where the drug was applied.

This isn't an exhaustive list of possible side effects, and other side effects could be present. Consult your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.


A high dose of numbing medication can result in serious side effects in the event that too much medicine is absorbed into the body. This can happen when there is more application than the recommended dosage or when you keep a patch of skin on for too long.

Use and discard skin patches out of your pet's reach.

Before you take this drug

It is not recommended to make use of Pliaglis if you are allergic to:

  • Any kind of numbing drug, any type of numbing medicine
  • Sunscreen or any other skin care products that contain para-aminobenzoic acids (paba).

Overdoses that have killed people occur when numbing drugs are administered without the guidance of a medical professional (for example, during an aesthetic procedure such as the removal of hair using lasers). Be aware that numerous cosmetic procedures can be performed without a physician present.

It is recommended that the Pliaglis cream not be applied to a child less than 3 years old. This stretchy patch for skin is not allowed to be used by anyone less than the age of 18.

Speak to your doctor if you were ever diagnosed with:

  • The liver condition;
  • A blood cell disorder known as methemoglobinemia (in you or a family member);
  • A genetic nzyme deficiency called glucose-6-phosphate dehydrogenase (g6pd) deficiency;
  • An illness for which you use a heart rhythm medicine or
  • Allergic reaction to other medicines employed for anesthesia.

People who are older and suffer from debilitation might be more susceptible to adverse effects from this medication.In the event that you use Pliaglis on your chest, stay clear of the areas that could come into contact with your baby's mouth.

Patches made of lidocaine and tetracaine transdermal patches could cause skin burns when worn while undergoing an MRI (magnetic imager). Do not wear the patch prior to the test.

How to take Pliaglis?

Follow all the instructions on your prescription label, and go through all medication guides or instructions sheets. Don't use this medicine in greater quantities or for longer than the time prescribed. The medication is usually applied between 20 and 30 minutes prior to your treatment (or 60 minutes prior to the procedure to remove your tattoo). Pliaglis is available as either a cream or a skin patch.

If you take this medication at home, you must read carefully and follow any instructions for use that are included in your medication. Talk to your pharmacist or doctor for clarification if you are unsure of these directions. Do not chew it. Topical medicines are intended for use exclusively on your skin. If this medication gets into your nose, mouth, vagina, rectum, or mouth Rinse by rinsing with clean water. To perform a cosmetic procedure, an expert in medicine or another health care professional will apply this treatment to your skin.

If you apply Pliaglis patches for skin, only apply them to clean, dry, healthy skin areas that you want treated. Beware of skin that is raw or has blisters. Apply the patch with firm pressure to secure it. There may be a warm sensation, which is normal, but it shouldn't be unbearably hot.

Wash your hands following the application of the patch to your skin. After the prescribed numbing, remove the patch from your skin. Then, cleanse and disinfect the skin according to the recommendations of your physician. After removing the skin patch, fold it in half, putting the sticky side in, and dispose of it in a location that is out of your reach from children and pets.

Keep skin patches that are not used at room temperature away from heat and moisture. The skin patches must be kept out of a pet's or child's reach. The quantity of medicine contained in patches can be harmful to a young child or pet that accidentally chewed or swallowed patches. Seek emergency medical care if this happens.

Do I be concerned if I miss a dose?

Because Pliaglis is taken in one dose, it doesn't include a daily dosage schedule.

What will happen if I take excessively?

Get medical attention immediately, or contact us for help at the Poison Help Line at 1-800-222-1222. A high dose of numbing medications can lead to death if excessive amounts of the drug are absorbed into your skin and blood.

Your body might take in too much plaque if:

  • If you apply more than the recommended dosage,
  • You apply the medication to skin that has been damaged or inflamed.
  • If you have had a skin patch over your face for a long period of time,

The symptoms of an overdose can include numbness or tingling on your face and ears, ringing, as well as drowsiness, nausea, and slurred or distorted speech. The most serious complications of lidocaine and tetracaine can include seizures (convulsions) or reduced breathing, coma, the heart failing, and the respiratory system failing (breathing ceases).

What should be avoided?

Do not let this medication get into your eyes. Should it happen, wash with water. Don't apply the skin patch when it is damaged or cut.

Be careful not to touch the sticky side of the patches of skin when applying it. Do not get a "live" vaccine while using lidocaine or tetracaine. The vaccine might not work in the same way and might not be able to fully protect you against diseases. The live vaccines are measles, rubella, and mumps (MMR), as well as polio, the typhoid virus, rotavirus, yellow fever, varicella (chickenpox), and shingles.

Interaction with other drugs

Skin care products are unlikely to be affected by any other medications you take. But certain drugs may cause problems that could be harmful to taking Pliaglis. Inform all of your health care providers about the drugs you are taking, such as prescription and non-prescription medicines, vitamins, and herbal remedies.