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Generic name: setmelanotide [SET-me-LAN-oh-tide]

Brand name: Imcivree
Dosage form: subcutaneous solution (10 mg/ml)
Drug class: melanocortin receptor agonists

What is Setmelanotide?

Setmelanotide is used to assist in losing weight and controlling appetite for those with genetic disorders who are 6 years of age or older.

Your doctor will conduct tests to determine if setmelanotide is the best treatment for you.Setmelanotide could be used for other purposes that are not mentioned in this guide.

Side effects of Setmelanotide

See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tonguesome individuals taking setmelanotide have reported experiencing suicidal thoughts after taking the medication, so if any sudden mood or behavior changes occur or any thoughts about suicide surface, inform your physician immediately.

Setmelanotide may cause serious side effects. Consult your doctor immediately if you experience:

  • An erection that lasts longer than four hours.

Common adverse effects of setmelanotide could include:

  • Inflammation, bruising, and redness Oozing or bleeding if the injection was administered;
  • Skin darkening;
  • Headache;
  • Erections without sexual activity in males
  • Nausea, vomiting, diarrhea, or stomach pain.

This list does not encompass all potential side effects; additional ones could occur. Please consult your physician or seek medical advice regarding possible effects; any serious adverse reactions should also be reported directly to FDA at 1-800-FDA-1088.


Take only according to the directions. Talk to your doctor if you take other medications or suffer from any medical conditions or allergies.

Prior to use this drug

Speak to your doctor if you were ever diagnosed with:

  • Kidney disease;
  • Depression or suicidal behavior or thoughts;
  • Darkened skin, including skin discoloration.

Being overweight when you are pregnant could affect the baby you are expecting. Inform your doctor if you are expecting or planning to be pregnant.Do not breastfeed.Setmelanotide could contain an ingredient that could result in serious side effects or even death for pre-mature or young babies. Do not give it to children without seeking medical advice.

How to take Setmelanotide?

Follow the directions on the prescription label and also read the medication guides or instructions sheets. Follow the medication exactly as prescribed.

Setmelanotide is injected into the skin daily at the time you get up at the start of the day.You can use setmelanotide in conjunction with or without food items.If you need help using an injection, seek advice from either your pharmacist or doctor.

Inject just when you are able to administer it. Inform your pharmacist if medicine is cloudy, appears to have changed color, or contains particles.Do not reuse needles or syringes. Put them in an impervious-to-punch "sharps" container and dispose of them according to the laws of your state or municipality. Store them out of reach from pets and children.

The doctor could advise you to stop taking setmelanotide in the event that you haven't lost a certain amount of weight within a specific amount of time of treatment.You must undergo an exam of the skin prior to and after the treatment using setmelanotide.Follow the storage guidelines provided by Setmelanotide. Your pharmacist can give you more details on the best way to keep this medication.

What happens if I miss the dose?

Do not miss the missed dose, and take your next dose according to the time you normally take it. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions regarding food, drinks, or any activity.

Interaction with other drugs

Other medications can affect setmelanotide's effects, such as prescription or OTC medicines, vitamins, and herbal products. Inform your physician of any other medications you are taking.