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Generic name: plecanatide [ple-KAN-a-tide]
Brand name: Trulance.
Dosage Form: oral tablet (3 mg)
Class of drug: guanylate cyclase-C antagonists

What is Plecanatide?

Plecanatide is a treatment for chronic idiopathic constipation, or the irritable constipation caused by constipation. Plecanatide is also employed for other purposes that are not covered in this medication guide.

Side effects of Plecanatide

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, and swelling of your lips, face, or tongue.

Diarrhea can be one of the most common side effects of using plecanatide. Stop taking plecanatide and consult your physician immediately when you have severe diarrhea.

This isn't a complete list of possible side effects, and others could happen. Contact your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.


It is not recommended to use plecanatide if there is an obstruction inside your digestive tract.

Don't give plecanatide to any child who is younger than six years of age. Plecanatide is not permitted to be used by anyone younger than 18 years old.

Before you start taking this medicine

It is not recommended to use plecanatide if your body is allergic to it or if you suffer from:

  • an obstruction inside your digestive tract.

Don't give this medication to children younger than six years old.

Do not use plecanatide on anyone less than 18 years of age. In animal studies, the drug resulted in extreme dehydration that led to death.

Inform your doctor if you are breastfeeding or pregnant.

Similar/related drugs

Linzess, Amitiza, Lubiprostone, Trulance, Linclotide, Motegrity, and Ibsrela

How to take Plecanatide?

Follow the directions on your prescription label, and review all medication guides and instructions. Follow the medication exactly as prescribed. Take the tablet whole, whether or not you are eating.

If you are unable to swallow the tablet completely, you can crush it and mix it with the help of a spoonful of liquid or applesauce. Drink this mixture immediately. Don't save it for a later time. The tablet mix with water could also be administered via an nasogastric (NG) tube for feeding with a syringe that is catheter-tipped. Take note of and adhere to any instructions that are included with your prescription. Consult your physician or pharmacist for clarification if you are unsure of these directions.

Place it in a cool, dry place free of heat and moisture. Store the tablets in the original bottle and blister packs until you're ready to start taking them. You can take the coil that is used to pack the bottle. However, you should keep the package or container of preservative that absorbs moisture in the bottle.

Details on dosage

Usual Adult Dose for Chronic Idiopathic Constipation:

3 mg taken orally every day

Use: Treatment for chronic constipation caused by idiopathic constipation (CIC)

Usual Pediatric Dose for Chronic Idiopathic Constipation:

Under age 6 years: contraindicated.
Ages 6 to 18 years Do not recommend

Do I be concerned if I miss a dose?

You should take the medication as quickly as you can. However, avoid any missed doses if you are nearing the time to take the next dose. Don't have two doses at one time.

What will happen if I take excessively?

An overdose of plecanatide should not be thought to be a danger. Get medical attention immediately, or contact the Poison Help Line at 1-800-222-1222. If you have accidentally taken the drug, A child younger than 6 who is taking plecanatide could be extremely dehydrated.

Side effects of Plecanatide

Follow the instructions of your physician regarding any restrictions on your food, drink, or any activity.

Interaction with other drugs

Other medications can affect plecanatide, such as prescription and over-the-counter drugs, vitamins, and herbal products. Discuss with your doctor all the medicines you are currently taking and any medication you begin or stop taking.





Prescription only

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