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Name of the Generic: Selegiline (oral) (oral) se-LE-ji-leen se-LE-ji-leen
Names of Brands: Eldepryl, Zelapar
Drug Classes: Dopaminergic antiparkinsonism agents, monoamine oxidase inhibitors

What is Zelapar?

Zelapar helps prevent the breakdown of a chemical within your brain known as dopamine. Dopamine levels are too low and are linked to Parkinson's disease.

Zelapar is used alongside levodopa and carbidopa to treat signs of Parkinson's illness. It assists levodopa in its fight against Parkinson's disease over longer periods of time.Zelapar is also employed for other purposes that are not covered in this guideline.


Potentially dangerous drug interactions can be experienced when certain medications are taken in conjunction with Zelapar. Tell each of your healthcare professionals about any medications you are taking now, as well as any other medications that you are able to stop or begin taking.

Before you take this drug

It is not recommended to take Zelapar when you have an allergy to selegiline or have had fluoxetine (Prozac or Sarafem, among others) in the last 5 weeks.

Certain medications can trigger unwanted or harmful effects when combined with Zelapar. Your doctor might have to alter your treatment plan when you take any of the following medications:

  • Cough medicine containing dextromethorphan
  • Cyclobenzaprine (flexeril);
  • Meperidine (demerol) or another narcotic (opioid) pain medication;
  • Methadone;
  • John's wort;
  • Tramadol (ultram, ultracet);
  • An antidepressant, citalopram, desvenlafaxine, fluvoxamine, levomilnacipran,milnacipran, mirtazapine, nefazodone, paroxetine, venlafaxine, vilazodone, and others;
  • An mao inhibitor is isocarboxazid, linezolid, methylene blue injection, rasagiline, phenelzine, tranylcypromine, and many others.

When you stop taking zelapar, you must be patient for a minimum of 14 days before starting any of the drugs that are listed above.

To ensure that zelapar is suitable for you, inform your doctor if:

  • Kidney disease or liver failure;
  • High blood pressure
  • Phenylketonuria (zelapar tablets, which dissolve orally, could contain the chemical phenylalanine).

Patients with Parkinson's disease might be at greater risk of being diagnosed with skin cancer (melanoma). Consult your physician about the risk and the signs of skin cancer to look out for.

It isn't known if Zelapar can harm an unborn child. Consult your physician if you are expecting or planning to become pregnant.It isn't known if selegiline gets into breast milk or whether it is harmful to the nursing infant.Tell your physician if you are nursing a child.

How to take Zelapar?

You should take Zelapar exactly as it was prescribed to you. Follow the instructions on the prescription label. Your doctor might alter your dosage to ensure you are getting the best outcomes. Avoid using this medication in greater or lesser amounts or for longer than prescribed. Do not alter your dosage or schedule of medication without your physician's guidance.

Zelapar tablets that are disintegrating are recommended to be taken every day, before breakfast, and with no liquid.

While taking Zelapar and for the 14 days following the time you have stopped eating it, you should not consume food items listed within the "What should I avoid while using Zelapar?" part of the leaflet. Consuming these foods when you're taking Zelapar could raise your blood pressure to dangerous levels.

Foods you can eat are:

  • Fresh meat, poultry, and fish (including lunch hot dogs, meat breakfast sausages, and ham that has been cooked and cut into slices);
  • Processed cheese, mozzarella, ricotta, and cottage cheese;
  • Pizzas made of cheeses with a low content of tyramine
  • Yogurt, soy milk,
  • Brewer's, or baker's, yeast

To take Zelapar Orally disintegrating tablets:

  • Place the tablet in its blister package until you're ready to consume the medication. Then, open the pack and peel back the foil that was inside the tablet's blister. Be careful not to press a tablet into the foil, or you could cause damage to the tablet.
  • With clean hands, take the tablet from your hands and place it on your tongue. The tablet will start to dissolve immediately. Be sure not to take the tablet whole. Allow it to melt into your mouth and do not chew. Take a few sips as the tablet disintegrates.
  • Avoid eating or drinking anything for at least five minutes after taking Zelapar tablets that dissolve orally.

Don't stop using Zelapar abruptly, or you could be a victim of harmful adverse consequences. To get the best results, continue taking the medication as directed.

Keep this medicine in a cool, dry place away from heat and moisture.

Save the Zelapar tablets inside the blister pouch made of foil until you're ready to take them. Discard any tablets that are not used within 3 months from the time you opened the pouch with your blister packet.

What happens If I miss a dose?

Do the missed dose as quickly as you can remember. Avoid your missed dose if you are nearing the time for your next dose. Do not take additional medication to compensate for the dose you missed.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

Overdose symptoms can include intense headaches, hallucinations, issues with vision, sweating, cold or clammy skin, an irregular or rapid pulse, the sensation of being lightheaded and faint, or a seizure (convulsions).

What should be avoided?

Beware of drinking alcohol while you take Zelapar.

When you take Zelapar, and for the 14 days following your stop, you are required to not eat any foods high in tyramine. This includes:

  • Air-dried meats and maturing or fermented meats: salami or sausage (including mortadella and cacciatore); sherry pickled;
  • Any food item that is spoiled or stored improperly, such as meat, poultry, fish, or livers;
  • A beer that is tapped is a beer that hasn't been pasteurized.
  • Aged cheeses that have been aged (such as blue swiss and cheddar parmesan as well as romano cheese);
  • Prescription or cold medications that contain tyramine
  • Sauerkraut, soy beans, soy sauce, tofu, fava beans,
  • The yeast extracts (such as Marmite).

Tyramine consumption while taking selegiline could elevate the blood pressure of your patients to levels that could result in life-threatening adverse effects. It is important to be acquainted with what foods you should stay clear of while taking selegiline.

Zelapar can affect your thinking or reactions. Certain people who take this medication have experienced insomnia during routine activities during the day, such as eating, working, talking, or driving. You might fall asleep quickly, even after being alert. Be aware if you are driving or engaging in any activity that requires you to remain conscious.

Side effects of Zelapar

See a doctor immediately. If you are experiencing symptoms of an allergic reaction to Zelapar, such as difficulty breathing, hives, or swelling of your lips, face, or tongue,

See your doctor right away if you are suffering from:

  • A feeling of lightheadedness, as if you're passing out;
  • Trouble breathing
  • Hallucinations, confusion, bizarre thoughts, or behaviors;
  • More tremors, or uncontrolled muscle movements;
  • The effects of the other medications you take;
  • Serotonin levels that are elevated within the body (when combined with an antidepressant) (when taken with an antidepressant) include anxiety or fever, rapid heart rate, excessive reflexes, nausea, vomiting, diarrhea, inability to control, and fainting.
  • Blood pressure is dangerously high with severe headaches, eyes that are blurred, the sound of pounding on your ears or neck, nausea, anxiety, vomiting, chest pain that is severe breathing problems, shortness of breath, beating heart beats that pound, or seizures (convulsions).

You might experience more sexual urges, unusual cravings for gambling, or any other intense desires while taking this medicine. Consult your physician when this happens.

Common Zelapar side effects can include:

  • Dizziness;
  • Nausea, stomach pain, constipation;
  • The skin, or any other irritation;
  • Sleep problems (insomnia);
  • Mouth ulcers or sores and pain when swallowing (while taking Zelapar tablets disintegrating orally).

This isn't a complete list of all the side effects. Other side effects could be present. Contact your doctor for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Numerous drugs may be incompatible with selegiline, and certain drugs shouldn't be used in conjunction with each other. This includes prescription and non-prescription medications, vitamins, and herbal supplements. There are not all the interactions mentioned in this medication guide. Discuss with your doctor the medicines you are taking as well as the medicines you begin or stop taking in the course of treatment with Zelapar. Provide a complete list of the medicines you take to any healthcare professional who cares for you.



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