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Generic name: pimavanserin [PIM-a-VAN-ser-in]
Drug class: atypical antipsychotics

What is Nuplazid?

Nuplazid is an antipsychotic medication that works by altering the action of chemical substances within the brain. Nuplazid can be used to treat hallucinations and delusions brought on by psychosis, which is connected to Parkinson's disease.


Nuplazid isn't recommended for use in elderly patients suffering from dementia-related psychosis.

Before you take this drug

Nuplazid could cause an increase in the likelihood of death for people with psychosis related to dementia. It is not recommended for use in this situation.

Nuplazid is not recommended if you are allergic to pimavanserin. Inform your doctor if you have ever suffered from:

  • A heart rhythm disorder
  • Long QT syndrome (in either you or a member of your family);
  • Kidney disease kidney disease
  • The imbalance of electrolytes (such as low concentrations of magnesium, potassium, or magnesium in the blood).

It is unclear if this medicine could affect a newborn baby. Inform your doctor if you are expecting or planning to be pregnant. It is not recommended to breastfeed while using this medication. Consult your physician regarding any risks.

How to take Nuplazid?

Nuplazid is typically taken at least once a day. Follow the instructions on the prescription label and go through all medication guides and instructions sheets. Make sure you use the medicine exactly as prescribed.

You can use Nuplazid either with or without meals. If you are unable to swallow the capsule completely, open it and add the medicine in the form of a spoonful of pudding yogurt, applesauce, or a nutritional drink. Take the drink immediately without chewing. Do not store the mixture for a later time. If you decide to stop or start using other medicines, the doctor may have to alter your Nuplazid dosage. Place it in a cool, dry place free of heat and moisture.

Related drugs


Dosing information

Usual Adult Dose for Psychosis:

34 mg (as two tablets with 17 mg) every day, taken orally.

Comment: This medication does not need any titration.

Treatment for hallucinations, delusions, and hallucinations that are a result of Parkinson's psychosis

What happens if I miss a dose?

Do not take the medicine for as long as you can. However, do not take any missed doses if it's close to the time of the next dose. Don't have two doses at one time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

An overdose may cause nausea and vomiting.

What should be avoided?

Beware of drinking the alcohol. Dangerous side effects may be experienced.

Side effects of Nuplazid

See a doctor immediately. If you are experiencing symptoms that indicate an allergy reaction, Nuplazid: hives and breathing problems or swelling of your lips, face, and tongue.

See your doctor right away. If you are suffering from:

  • Rapid heartbeats or fast beats, the heart beating fast;
  • Shortness of breath;
  • Suddenly dizziness that is sudden (like the feeling you're about to pass out).

Common side effects of Nuplazid include:

  • Confusion or
  • Swelling of your feet or hands.

This isn't a complete list of possible side effects, and other side effects could be present. Contact your doctor for advice regarding medical effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

There are times when it's not safe to take certain medications in combination. Certain medications can alter the blood levels of other medications you are taking, which could cause more side effects or make the medication less effective.

The dose of pimavanserin you take may require adjustments if you are taking other medicines. It is crucial to notify your doctor if you decide to stop or start taking any other medication. Nuplazid could cause a serious heart issue. Your risk of developing heart problems is higher if you take certain other medications for asthma, infections, and heart conditions such as high blood pressure, depression, mental illness, malaria, cancer, or HIV.

Numerous drugs may be a problem for pimavanserin. This includes over-the-counter and prescription drugs, vitamins, and herbal products. The interactions of all drugs are not mentioned here. Discuss with your physician all of your medications as well as any new medication you are about to start or stop taking.