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Generic name: granisetron (transdermal) [gra-NIS-e-tron]
Drug class: 5HT3 receptor antagonists

What is Sancuso?

Sancuso blocks the effects of the body's chemicals, which can trigger nausea and vomiting.Sancuso skin patches help stop the nausea or vomiting due to chemotherapy for cancer.Sancuso can also be employed for other purposes that are not covered in this guideline.


Before taking Sancuso, consult your physician, whether you suffer from a stomach or intestinal problem, have recently undergone an operation on your stomach or the intestinal tract, or have ever experienced reactions to an allergen or form of patch for the skin that is medicated. It is possible that you will require an adjustment in dosage or other tests to use Sancuso safely.

Follow the directions on your prescription label and on the label of your package. Be sure to inform your healthcare professionals about your allergies, medical conditions, and any other medications you take.

Do not expose the patch or the upper arm to the sun or sunlamps. Also, avoid tanning beds. Artificial or natural sunlight may cause skin reactions when the Sancuso patch is placed. The reaction can last at least 10 days following the time that the patch has been removed. Protect your arms when you are wearing the patch for a minimum of 10 days following the removal of the patch. Avoid using Sancuso during the time you are not receiving chemotherapy unless your physician has instructed you to.

Prior to use this drug

Sancuso is not recommended. If you are sensitive to the granisetron

To be sure Sancuso is appropriate for you, consult your doctor if:

  • An intestinal or stomach disorder;
  • If you've undergone stomach or intestinal surgery, for example,
  • If you've had allergies to any kind of patch that has been medicated for skin,

Sancuso isn't expected to harm a baby who is not yet born. Consult your physician if you are expecting or plan to become pregnant while receiving treatment.

It's not clear if the granisetron in breast milk is passed on to babies or if it harms the nursing infant. Inform your doctor if you are breastfeeding a baby.

How to take Sancuso?

These Sancuso patches on the skin are generally applied between 24 and 48 hours prior to the beginning of the chemotherapy. Follow all the instructions on the prescription label. Do not take this medicine in smaller or larger quantities or for longer than prescribed.

The Sancuso patch is applied to dry, clean, and hairless skin on the outside of the upper arm. Make sure to avoid placing it on skin that's sensitive, red, or damaged. Apply the patch with a firm press into its place, and ensure that it's sealed at the edge.Keep the patch in place throughout your chemotherapy treatment and for a minimum of 24 hours after treatment is finished. Remove the patch carefully when you are removing it.

You can continue to wear the Sancuso patches for up to 7 days, if you require it, based on the chemotherapy regimen you are following. Follow the instructions of your doctor for dosing with care.Pick a different area on your body to apply the patch to every time you wear it. Don't use the same area of your skin twice within seven days.Don't wear more than a single Sancuso patch at any given time. Using extra skin patches won't make the treatment more efficient. Do not cut skin patches.

If the patch gets ripped off, then try to stick it back in place. If it isn't sticking well, you can put on another patch and wear it for the remainder of your wear time. Don't alter the time frame for removing your patches.After you have removed the patch and folded it in half so that it is firmly bonded, put it in a safe place so that pets or children are not able to access it.Sancuso won't be effective if you continue taking it even when you're not getting chemotherapy.Don't share this medicine with anyone else.Each patch should be kept in the foil pouch until you are ready to use it. Keep the pouches in the original containers kept at room temperature and away from heat and moisture.

Details on dosage

Normal adult dose to treat nausea or vomiting The Sancuso Transdermal System applies a patch to the upper extremity at least 24 hours prior to the start of chemotherapy. The patch can be placed for up to 48 hours prior to chemotherapy, if appropriate. Take off the patch at least 24 hours after treatment has been completed. The patch is able to be worn for up to 7 days, based on the length of the regimen. The Sancuso Transdermal System is a 52-cm2 patch that contains 34.3 mg of Granisetron. It lets off 3.1 milligrams of granisetron every day for as long as 7 days.

A transdermal patch (patch) is to be applied to dry, clean, healthy, and intact skin on the upper arm. Sancuso patches are not recommended for skin that is irritated, red, or damaged. The patch is placed in a pouch and should be applied immediately after the pouch is opened. The patch shouldn't have to be cut into pieces.

What happens if I miss the dose?

Contact your doctor for advice. If you do not apply a Sancuso patch to your skin for at least 24 hours prior to when your chemotherapy program is scheduled to begin, Don't apply additional patches to replace the missing dose.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

While wearing the skin patch, be careful not to expose yourself to sunlight or tanning beds. Natural or artificial sunlight may cause a skin reaction when the Sancuso patch for skin is used. The reaction can last at least 10 days once the patch has been removed. Protect your arms when you are wearing the skin patch for a minimum of 10 days following the removal of the patch.

Do not cover your skin by using heating pads. Heating pads could increase the amount of drugs absorbed by your skin, which can cause adverse consequences.

Side effects of Sancuso

Take immediate medical attention. If you experience any symptoms that indicate an allergy reaction with Sancuso, like hives, trouble breathing, or swelling of your lips, face, or tongue,

Take off the patch on your skin and contact your doctor at anytime if you suffer from:

  • The swelling or pain in your stomach;
  • Extreme redness, itching, swelling, or any other irritations when the patch is placed; or
  • Serotonin levels are high in the body and can cause hallucinations, agitation, and a rapid heart rate. Excessive reflexes, nausea, diarrhea, vomiting, loss of coordination, and fainting.

Some common side effects of Sancuso include:

  • Constipation;
  • Headaches
  • Minor skin irritations where the patch was placed.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on the effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Utilizing Sancuso in conjunction with certain other medications could cause the levels of serotonin to increase in your body. This is an issue known as "serotonin syndrome," which could be fatal. Consult your physician if you are also taking:

  • Lithium;
  • Ritonavir;
  • John's Wort;
  • An antidepressant
  • Medicine for migraine headaches;
  • A drug called a narcotic (opioid) medication, a muscle relaxer,
  • Other medications to treat nausea

This list isn't comprehensive. Other medications can be incompatible with granisetron, such as medications that are prescribed and available over the counter, as well as vitamins and herbal products. Not all interactions are included in this guideline. Discuss with your doctor the medicines you are taking as well as the medicines you begin or stop taking while you are taking Sancuso.