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Jentadueto XR

Generic name: linagliptin and metformin [LIN-a-GLIP-tin-and-met-FOR-min]

Brand names: Jentadueto, Jentadueto XR
Combinations of anti-diabetic drugs

What is Jentadueto XR?

Jentadueto and diabetes XR help control blood sugar. Metformin reduces glucose production in the liver and decreases glucose absorption by the intestines. Linagliptin regulates the levels of insulin that your body produces following a meal.

Jentadueto XR is a combination medication used in conjunction with diet and physical activity to control blood sugar levels among adults with type 2 diabetes mellitus. Jentadueto is not intended to treat type 1 diabetes. Jentadueto XR can be used in other ways not mentioned in this guide.

Side effects of Jentadueto XR

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to the skin (fever or sore throat with burning eyes, skin rash, blisters, and peeling), seek emergency medical attention.

If you experience any of the following symptoms: severe abdominal pain that spreads to your back; nausea or vomiting; loss of appetite or rapid heartbeats,

The mild symptoms of lactic acidosis can worsen over time. This condition is fatal. If you experience: unusual muscular pain; trouble breathing; stomach pain or vomiting; fast or slow or abnormal heartbeats; or dizziness,

Jentadueto XR may cause serious side effects. If you experience:

  • A severe autoimmune response—itching, blisters, and breakdown of the outer skin layer;
  • You may experience severe joint pain or discomfort.
  • Symptoms of heart failure include shortness of breath (even when lying down) and swelling in the legs or feet. Rapid weight gain.

Side effects of Jentadueto XR include:

  • Sore throat
  • Sinus pain, stuffy nose, or
  • Diarrhea.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


Jentadueto XR should not be used if you suffer from severe kidney disease or diabetic ketoacidosis. Consult your doctor to get treatment.

You can develop lactic acidosis. This is a dangerous buildup of lactic acid in your blood. If you experience unusual muscle pains, difficulty breathing, irregular heartbeats, dizziness, or vomiting, or feel cold or weak, seek emergency medical attention.

Before you take this drug

This medicine should not be used if you're allergic to metformin or linagliptin. Also, if your kidneys are severely damaged or you have diabetic ketoacidosis, Call your doctor for insulin treatment.

Tell your doctor about any of the following:

  • Kidney disease
  • Heart disease
  • Liver disease
  • Pancreatitis;
  • Gallstones;
  • Alcoholism; or
  • High triglycerides

You can develop lactic acidosis. This is a dangerous buildup of lactic acid in your blood. You may be at greater risk if your medical condition is severe, you suffer from an infection, or you drink alcohol regularly. Consult your doctor to determine your risk.

You may have to temporarily stop using Jentadueto XR if you are scheduled for surgery or a type of x-ray or CT scan that uses a dye injected directly into your veins. Tell your caregivers that you're taking this medication. Inform your doctor if you are pregnant or nursing. If you're pregnant or plan to become pregnant, follow your doctor's advice about this medicine.

This medicine can stimulate ovulation and increase the risk of unintended pregnancies in women who are not yet menopausal. Speak to your doctor about the risks. The use of this medicine by those under 18 is not recommended.

How to take Jentadueto XR?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label. If your doctor has not told you otherwise, take Jentadueto XR along with a meal. Do not chew or crush the tablet.

If you have low sugar, then you may feel irritable, confused, or anxious. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (such as fruit juice, hard candies, crackers, or raisins). In the event of severe hypoglycemia, your doctor may prescribe a glucagon injectable kit. Make sure that your family and friends are familiar with how to administer this injection in case of an emergency. Watch for signs such as increased thirst and urination.

Stress, illness, surgery, and alcohol consumption can affect blood sugar levels. Consult your doctor before making any changes to your medication or dose schedule. Jentadueto XR may be part of a comprehensive treatment program that includes diet, exercise, and weight management, as well as blood sugar testing and other medical attention. Please follow your doctor's advice. Store away from heat and moisture at room temperature.

What happens if I miss the dose?

If you are close to your next dose, skip the missed dose. Never take two doses of the same medicine at once.

What happens if I overdose?

You should seek emergency medical care or call Poison Help at 1-800-222-1222. You may be suffering from a severe low blood sugar level (extreme weakness or nausea, tremors, sweating, confusion, difficulty speaking, rapid heartbeats, or seizures).

What should be avoided?

Avoid alcohol. Alcohol lowers your blood sugar levels and can increase the risk of lactic acidosis.

Interaction with other drug

Jentadueto XR can be affected by many drugs, causing it to become less effective or increasing your risk of lactic acidosis. These include prescription and non-prescription medicines, vitamins, and herbal products. This list does not include all possible interactions. Inform your doctor of all the medications you are taking, as well as any new ones.