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Generic name: sitagliptin [SI-ta-glip-tin]
Drug class: dipeptidyl peptidase 4 inhibitors

What is Januvia?

Januvia, an oral diabetes medication that controls blood sugar levels, is available. It regulates the levels of insulin that your body produces following a meal.

When combined with diet and physical activity, Januvia can help improve blood sugar levels in adults with type II diabetes mellitus. Januvia does not treat type I diabetes.


Januvia should not be used if you have diabetic ketoacidosis. Call your doctor to get insulin treatment. If you experience any of the following symptoms: shortness of breath, swelling of your feet or legs (even when lying down), or rapid weight gain,

If you experience pancreatitis, stop taking Januvia immediately and contact your doctor. These symptoms include severe abdominal pain that spreads to your back with or without nausea.

Before you take this drug

Januvia should not be used if you are allergic or have diabetic ketoacidosis. Call your doctor to get insulin.

Tell your doctor about any of the following:

  • Kidney disease (or dialysis if you have it);
  • Heart problems
  • Pancreatitis;
  • High triglycerides
  • Gallstones
  • Alcoholism.

You may need to adjust your dosage during each trimester. High blood sugar can cause complications for both mother and baby.

You may be required to register your name on the Januvia pregnancy registry once you begin using this medication.

You may not be able to breastfeed your baby if you are taking this medication. You should ask your doctor if there are any risks.

Anyone younger than 18 is not allowed to use Januvia.

Rrelated drugs

Ozempic, Mounjaro, Metformin, Trulicity, Lantus, Victoza, and Tresiba

How to take Januvia?

Follow all directions listed on your prescription label and read all instruction sheets provided with it. When your doctor changes the dosage, take exactly as prescribed; Januvia may be taken with or without food - please follow his or her advice for best results.

You may have to go to your doctor for blood tests and blood sugar checks. If you have low blood glucose (hypoglycemia), you may feel very hungry or dizzy. You might also be confused, anxious, or If you want to treat hypoglycemia quickly, consume or drink something that will provide sugar fast (fruit juices, crackers, raisins, or non-diet soda).

If you suffer from severe hypoglycemia, your doctor may prescribe an injection kit. Make sure that your family and friends are familiar with how to administer this injection. Watch for other signs of hyperglycemia, including increased thirst, headaches, fatigue, and blurred vision.

Exercise, alcohol, surgery, and stress can all affect blood sugar levels. Consult your doctor before changing the dose or schedule of your medication. Januvia may be part of a comprehensive treatment plan that includes diet, exercise, and weight management, as well as blood sugar testing and other medical attention. You should follow your doctor's advice. Store away from moisture, heat, and light at room temperature.

Details on dosage

Adult dosage for diabetes type 2:

Usual dose: 100 mg once daily orally

Comments: If used with an insulin-secretagogue, such as sulfonylurea (e.g., sulfonylurea or insulin), they can be used in combination to reduce hypoglycemia.

Use: To improve the glycemic level in patients with type II diabetes mellitus.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Low blood sugar can cause extreme weakness, blurred or distorted vision, sweating, and difficulty speaking. Other symptoms include tremors, confusion, nausea, stomach pains, confusion, and seizures (convulsions).

Avoid this

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Side effects of Januvia

If you experience any of the following symptoms: hives, difficulty breathing, swelling on your face or in your throat, or severe skin reactions (fever or sore throat with burning eyes, pain in your skin, a red or purple rash that spreads, blisters, and peeling skin),

If you experience any of the following pancreatitis symptoms, stop taking Januvia immediately and contact your doctor.

If you experience:

  • Severe autoimmune response itching, blisters, and breakdown in the outer layer of skin;
  • You may experience severe pain or persistent joint pain.
  • There is little or no urine production.
  • Symptoms of heart disease shortness of breath, swelling of the legs or feet, and rapid weight gain.

Januvia may cause side effects such as:

  • Low blood sugar
  • Headache
  • Sore throat, runny, or stuffy nasal discharge

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Interaction with other drug

You may find that Januvia does not work as well if you are taking other medications. Other drugs can also have an impact on blood sugar levels.

If you use insulin, your chances of having low blood sugar may increase.

Sitagliptin can be affected by other drugs, such as prescription and over-the-counter medicines, herbal products, vitamins, and supplements. Inform your doctor of all the medicines you are currently taking and those that you will begin or stop using.

Included are prescription and non-prescription medicines, vitamins, and herbal supplements. This list does not include all possible interactions. Inform your doctor of all medications you begin or stop taking.