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Brand names: Cambia (dye-KLOE fen-ak), Cataflam (dye-KLOE fen-ak), Lofena (zipsor), Zorvolex
Drug Class: Nonsteroidal Anti-Inflammatory Drugs

What is Lofena?

Lofena, a nonsteroidal inflammatory drug (NSAID), is used for mild to moderate pain or to treat the signs and symptoms of osteoarthritis.Lofena (Cambia) is used for a headache or migraine attack. Cambia can only be used to treat a headache that has already started. Cambia will not reduce headaches or prevent them.This medication guide does not list all possible uses of Lofena.

Side effects of Lofena

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to the skin (fever or sore throat with burning eyes, skin pain or blisters, or a red or purple rash that is blistering or peeling), seek emergency medical attention.If you experience a severe drug reaction, such as a skin rash or fever, muscle pain, weakness, unusual bruises, or yellowing, stop using Lofena immediately and consult a doctor.Seek immediate medical care if you notice any of the symptoms.

Lofena can cause serious side effects. If you experience:

  • The first sign of any skin rash is important, regardless of how mild it may be.
  • Flu-like symptoms;
  • Heart problems: swelling, rapid weight gain, and feeling short of breath.
  • Kidney problems: little or no urinating;painful or difficult urination; swelling of the arms or legs; or feeling tired and short of breath.
  • Liver problems nausea; diarrhea; stomach pain (upper-right side); fatigue; itching; dark urine; jaundice.
  • Signs of stomach bleeding include bloody or tarry stool, vomiting blood, or vomit that looks like coffee grounds.

Lofena side effects may include

  • Indigestion, gas, nausea, vomiting, stomach pain;
  • Diarrhea, constipation;
  • Headache, dizziness, drowsiness;
  • Abnormal lab tests;
  • Itching, sweating;
  • Stuffy nose;
  • Increased blood pressure
  • You may experience swelling in your arms and legs.

There may be other side effects. Call your doctor for medical advice about side effects. To report adverse effects, you can contact the FDA at 1-800-FDA-1088.


Lofena may increase your risk of a fatal stroke or heart attack. Lofena should not be used before or after heart bypass surgeries. This medication can also cause fatal stomach or intestinal bleeding.

Before you take this drug

Lofena may increase your risk of a fatal heart attack or stroke, even if there are no risk factors. This medicine should not be used before or after heart bypass (coronary arterial bypass graft, or CABG).Lofena can also cause fatal stomach or intestinal bleeding. You may not be aware of these conditions if you use this medication, particularly if you are older.Lofena should not be used if it is allergic to you or if your allergic reaction was severe after you took aspirin.Cambia should not be used to treat cluster headaches. Zipsor should not be used if you have an allergy to beef protein or beef.

Inform your doctor if you experience any of these symptoms:

  • High blood pressure, heart disease
  • If you have stomach ulcers or bleeding, it is important to seek medical attention.
  • Asthma;
  • Liver or kidney disease
  • If you smoke.

While taking Lofena, it is possible that you will have a harder time getting pregnant.Do not take Lofena if you are pregnant unless you have been told to by your doctor. NSAIDs can cause kidney or heart problems for the unborn child and other complications during pregnancy.Breastfeeding may not be possible while taking this medication. You should ask your doctor if there are any risks.Lofena should not be used by anyone under the age of 18.

How to take Lofena?

Lofena is available in different brands and can be used for different purposes. You may need to adjust your dosage if you change brands. You should follow your doctor's advice on how much medication to take. If you have questions about the brand of Diclofenac that you received at the pharmacy, ask your pharmacist.Read all instructions on the label of your medication and follow all directions. Your doctor might occasionally adjust your dosage. Use the lowest effective dose to treat your condition.Do not chew or crush the tablet.Take Zorvolex with an empty stomach at least one hour before or two hours after eating.Use 1 to 2 ounces of water to dissolve Lofena (Cambia). Use only water. Mix the mixture well and consume it immediately. Take this medicine powder on an empty stomach.If your headache persists after taking Cambia, call your doctor.You may need to undergo frequent medical tests if you take Lofena for a long time.Store away from heat and moisture at room temperature. When not in use, keep the bottle tightly shut.

What happens if I miss the dose?

As soon as you recall, take the missed dose. If your next scheduled dosage is approaching, skip the missed dose. You should not take more medicine to compensate for a missed dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Avoid alcohol. Alcohol can increase the risk of stomach bleeding.Aspirin and other NSAIDs should only be taken if your doctor prescribes them.They may contain ingredients similar to Lofena (such as aspirin, a data-type="auto" href="">ibuprofen/a>, a data-type="auto" href="">ketoprofen/a>, or naproxen). These medicines may contain similar ingredients to Lofena, such as aspirin or ibuprofen. ketoprofen and naproxen.

Interaction with other drug

Before using Lofena, ask your doctor if you are taking an antidepressant. Certain antidepressants may cause you to bruise or bleed easily.

Tell your doctor what other medications you are taking, including:

  • Heart or blood pressure medications, including diuretics or "water pills";
  • Other forms of Lofena: Arthrotec, Flector (Pennsaid), Solaraze, Voltaren Gel
  • A blood thinner: warfarin Coumadin Jantoven
  • Other nsaids include aspirin, ibuprofen, naproxen, celecoxib, indomethacin, and meloxicam.

This list is incomplete. Lofena may interact with other drugs, such as vitamins and herbs. This list does not include all possible interactions with other drugs.