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Empagliflozin and linagliptin

Generic name: empagliflozin and linagliptin [EK-pa-gli-FLOW-zun-and-LIN-a-GLIP-tin]

Brand name: Glyxambi
Dosage format: oral tablet (10 mg–5 mg, 25 mg–5 mg)
The class of drugs: antidiabetic combinations

What are Empagliflozin and Lingliptin?

Empagliflozin, along with linagliptin, can be described as a mixture drug that can be used with exercise and diet to help improve blood sugar control in adult patients with diabetes mellitus type 2.Empagliflozin as well as linagliptin can be utilized to reduce the chance of dying from stroke, heart attack, or heart failure in people who suffer from type 2 diabetes and also suffer from heart disease.Empagliflozin and linagliptin are not used to treat type 1 diabetes.Empagliflozin as well as linagliptin could be used to treat conditions that are not mentioned in this guide.

Side effects of Empagliflozin and Linagliptin

Seek medical attention immediately. If you are experiencing symptoms that indicate an allergy, such as itching, peeling,  or flaking skin, trouble swallowing, difficulty breathing, or swelling of your lips, face, and tongue,You should seek medical attention immediately if you notice indications or warning signs of an underlying genital problem (penis vagina or penis): burning, itching, discharge, odor, redness, tenderness, pain or swelling in the rectal or genital region, fever, or not feeling well. The symptoms could worsen quickly.Empagliflozin and Lingliptin can cause serious adverse side effects. Consult your physician immediately. If you suffer from:

  • Burning sensation after you urinate, burning, and pain in the urinary tract;
  • A lightheaded sensation, similar to what you've passed out;
  • Blood sugar levels are low; headaches, hunger, sweating, and irritability. Also, dizziness, rapid heart rate, and feeling nervous or shaky
  • Heart conditions: swelling and weight gain, rapid or feeling tired,
  • Dehydration—dizziness, confusion, feeling very thirsty, less urination.
  • Stop taking this medication immediately and contact your physician as soon as possible.if you suffer from:
  • Chronic or constant joint pain that is persistent or constant;
  • Severe skin reactions—blanks, itching, and the breakdown of the skin's outer layer;
  • Ketoacidosis (too much acid in the blood) ketoacidosis (too much acid in the blood) vomiting, vomiting, nausea, stomach anxiety, confusion, pain, sleepiness, or difficulty breathing
  • Pancreatitis—severe discomfort in your stomach, which can spread into your lower back area; nausea; and vomiting.

Common negative effects of empagliflozin or linagliptin can be:

  • A bladder infection;
  • Cold symptoms like a running nose or stuffy nose, sneezing irritation of the throat.

This isn't a complete list of possible side effects, and others could happen. Contact your doctor for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Similar or related drugs

Ozempic, Mounjaro, metformin, Trulicity, Lantus, Victoza, and Levemir

Warnings

Stop taking empagliflozin or linagliptin and contact your doctor at the earliest opportunity if you notice symptoms of a serious adverse reaction, like extreme stomach discomfort (which may be aggravated into your lower back), nausea, fatigue, or difficulty breathing.Consult your physician if you are suffering from vomiting or diarrhea or if you consume less food or drink than normal.

This medication can lead to serious infections in the vagina or penis. Get medical help immediately if you experience irritation, burning or smell, discharge, pain or swelling, redness, tenderness of the rectal or genital region, fever, or do not feel well.

Before you take this drug

This medicine is for you if you're allergic to empagliflozin and linagliptin or if you suffer from:

  • Serious kidney diseases (or if you're dialysis-dependent);
  • A history of severe allergic or skin reactions following the use of linagliptin or empagliflozin;
  • Diabetic ketoacidosis (call your doctor for treatment).

Inform your doctor if you have ever suffered from:

  • Kidney or liver disease;
  • Bladder disease or problems with urination;
  • A pancreas disorder;
  • Heart failure;
  • Gallstones;
  • A sexually transmitted disease (penis or vagina)
  • Alcoholism, or if you are currently drinking a lot of alcohol.
  • If you are following an eating plan with low salt,
  • If you're 65 or older,
  • If you are planning an operation
  • The highest cholesterol or triglycerides.

Follow the directions of your doctor on how to use this medicine. If you are expecting or getting pregnant, Controlling diabetes is crucial during pregnancy.You shouldn't take linagliptin or empagliflozin during the third or second trimester of pregnancy.Do not breastfeed.

How to take Empagliflozin and Lingliptin?

Follow the directions on the label of your prescription and read the medication guide or instructions sheets. Your doctor may alter your dosage. Follow the medication precisely as prescribed.Empagliflozin is used in the morning, either with food or not.The blood sugar levels of your body will have to be monitored regularly, and you might be required to check the amount of ketones present in your urine. Empagliflozin may cause ketoacidosis, which is a life condition (too high levels of acid in the blood). Even if your blood sugar levels are normal, you should consult your doctor in the event that a urine test reveals that ketones are high in your urine.The blood sugar level can be affected by illness, stress, surgical procedures, drinking alcohol, or eating infrequently.Low levels of blood sugar (hypoglycemia) can make you feel hungry, dizzy, angry, or even unstable. To speedily manage hypoglycemia, consume or drink crackers, hard candy or raisins, juice of fruit, as well as non-diet beverages. Your physician may recommend glucagon injections in the event of extreme hypoglycemia.

It is possible to become dehydrated from an illness that lasts for a long time. Contact your physician if you are suffering from vomiting or diarrhea or consume less food or drink than normal.Empagliflozin and the linagliptin combination can alter the results of some laboratory tests that measure the presence of glucose (sugar) found in urine. Inform any doctor treating you about your use of empagliflozin and/or linagliptin.The treatment you receive could also include exercise, diet, and weight management, as well as specific medical treatment.Keep it at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose for Diabetes Type 2:

Dose for the first time: empagliflozin 10 mg; linagliptin 5 mg, once daily in the early morning.
If patients are responding to treatment, it is possible to increase the dosage to empagliflozin 25 mg and linagliptin mg twice a day.
Maximum dose: empagliflozin 25 mg; linagliptin 5 mg per day.
Comments:
It is not recommended for patients suffering from Type 1 diabetes mellitus since it can increase the likelihood of developing diabetic ketoacidosis among these patients.
It has not been investigated in patients who have a history of pancreatitis, and it is unclear if patients who have had a history of pancreatitis may be at a higher risk of developing pancreatitis while on treatment.
If used in conjunction with insulin and insulin secretagogues, a lower dosage of insulin or insulin could be needed to lessen the risk of hypoglycemia.
Uses:
as an aid to exercise and diet to increase glycemic control for people suffering from type 2 diabetes mellitus.
Empagliflozin can be used to lower the chance of dying from cardiovascular causes for patients suffering from diabetes mellitus and a history of cardiovascular disease.

What happens if I miss the dose?

You should take the medication as quickly as you are able, but do not take your missed dosage if it's nearing the time to take the next dose.Do not take two doses at the same time.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Do not drink alcohol.Take care not to rise too rapidly from either a lying or sitting position. You could be dizzy.

Interaction with other drug

Other medications can increase or reduce your effects of empagliflozin as well as the linagliptin drug on lowering blood sugar. Inform your doctor of your current medications and any that you decide to start or stop taking, particularly:

  • Insulin, or any other oral diabetes medications;
  • Rifampin (to combat tuberculosis)
  • A diuretic, or "water pill."

This list isn't complete. Other medications can affect empagliflozin and/or linagliptin. These include medications that are prescribed and available over the counter, vitamins, and herbal remedies. The interactions of these drugs are not mentioned in this medication guide.

DRUG STATUS

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Prescription only

Pregnancy & Lactation

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