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Generic name: antihemophilic and von Willebrand factor complex [AN-tye-HEE-moe-FIL-ik-and-von-WIL-e-brand-FAK-tor-KOM-plex]

Brand names: Alphanate, Humate-P, Wilate
Drug class: Other coagulation modifiers

What is Humate P?

The antihemophilic factor and von Willebrand factor are proteins that occur naturally in the blood. They help to make the blood clot.Hemophilia is caused by a lack of the antihemophilic factor VIII. Von Willebrand's disease is caused by a lack of von Willebrand factor. Humate-P temporarily increases the levels of von Willebrand or factor VIII in your blood. This helps with clotting.Humate-P is a combination of medicines used to treat bleeding episodes or prevent them in patients with von Willebrand's disease.Humate-P can also be used to treat or stop bleeding in patients with hemophilia A.This medication guide does not list every possible option for medication treatment. uses for Humate-P.

Side effects of Humate-P

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, chest tightness, difficulty breathing, feeling as if you may pass out, swelling on your face, lips, or tongue

Humate-P can cause serious side effects. If you experience:

  • When the injection is given, you may experience hot flashes.
  • Slurred speech or vision problems; sudden numbness (especially on one side) or weakness;
  • Coughing blood or a sudden cough
  • Pain, swelling, warmth, or redness on one or both legs
  • If you notice a pale or yellowed complexion, dark urine, a fever, or confusion, or if your skin is pale or yellowed, it may be advisable to consult a doctor.
  • Bleeding from a cut or the injection site;
  • Uncontrolled bleeding is a serious problem.

Some of the common side effects associated with Humate-P include:

  • Nosebleeds;
  • Itching or rash.
  • Numbness or tingling
  • Headache, dizziness,

There may be other side effects. For medical advice on side effects, call your doctor.Reaching out to the FDA can be done at 1-800-FDA-1088 if side effects arise, which should then be reported back.


This medication should not be used if you've ever experienced a severe reaction to antihemophilic factors in the past.Antihemophilic factors can become less effective if your body develops antibodies. If Humate-P is less effective at controlling bleeding, call your doctor.Read all instructions carefully about how to store the medicine. Different brands of antihemophilic complexes and von Willebrand factors may have different storage instructions.

Before you take this drug

This medicine should not be used if you've ever experienced a severe reaction to antihemophilic factors.Tell your doctor about any previous strokes or blood clots.You may be asked by your doctor to get a hepatitis vaccine before using Humate-P.This medicine is not known to harm an unborn child.Inform your physician immediately if you are pregnant or planning on becoming pregnant.It is unknown if antihemophilic factors and von Willebrand complex can pass into breast milk or if they could harm a baby who is nursing. You should tell your doctor if a child is breastfed.Humate-P comes from plasma, which is a part of blood that may contain viruses or other infectious agents. The plasma donated is treated and tested to reduce the possibility of it being infected, but it is still possible that it could spread disease. Speak to your doctor about any risks or benefits associated with using this medication.

How to take Humate P?

Do not exceed the recommended dosage or use Humate-P for longer than prescribed. Humate-P should not be used in excess or less than the recommended dose or for a longer period of time. Check the label of your medicine to ensure you're using the right strength.A vein is injected with Humate-P through an IV. It is possible that you will be taught how to use the IV at home. You should not administer this medication to yourself if you don't know how to inject the medicine and dispose of the needles, IV tubes, and other used items.You should read all the information provided, including medication guides and instructions. If you have questions, ask your doctor or pharmacist.Wash your hands prior to preparing your injection and administering it.Humate-P comes as a powder that needs to be mixed (diluent) before use. You should know how to mix and store the medicine if you use the injections in your home.Store the medication at room temperature after mixing it with a diluting agent. Use within 3 hours. Do not freeze or refrigerate.

Don't shake the medicine. Only prepare your dose in a syringe when you're ready to inject yourself. The single-use vial can only be used once. This vial should be thrown away after measuring the dose, even if medicine is still left inside.Humate-P should not be used if the color has changed or if there are particles present. For new medication, call your pharmacist.Only use a disposable syringe and needle once. Use a sharps container that is puncture-proof. Ask your pharmacist where to get one and how to dispose of it. Ask your pharmacist how to dispose of sharps in a container that is puncture-proof. This container should be kept out of the reach of pets and children.You may need to have frequent blood tests while taking this medication.Antibodies to antihemophilic factors can develop in your body, reducing their effectiveness. If this medication seems less effective at controlling bleeding, call your doctor.Follow all instructions on how to store the medicine. Storage instructions may vary depending on the brand name of the antihemophilic complex and von Willebrand factors.Keep the medicine and its diluent away from heat and moisture. Do not use any medicine after the date of expiration printed on the label.This medicine is best stored in its original container. Do not freeze. Take these items out of the fridge and let them reach room temperature before preparing your dosage.Do not put this medicine in the fridge if you have stored it at room temperature.You can wear a medical alert tag or carry a card that states you have von Willebrand or hemophilia. You should inform any medical provider that treats you about your bleeding or blood-clotting disorders.

What happens if I miss the dose?

You may not have a schedule for this medication, as it is often used only when necessary. If you have a regular schedule, take the missed dose immediately after you remember. If your next scheduled dosage is approaching, skip the missed dose. You should not take extra medicine to compensate for a missed dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.

Interaction with other drug

Humate-P may interact with other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your healthcare providers of all the medicines you are taking and those you plan to take.