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What is Infigratinib?
Infigratinib can be used to treat bile duct carcinoma with an abnormal "FGFR2 gene" that has spread (metastatically) to other parts after treatment and cannot be removed by surgery. Infigratinib is only prescribed if your doctor determines that you have a tumour of the right type.This medication guide does not list all possible uses of infigratinib.
Side effects of Infigratinib
Seek immediate medical attention if you experience any of these symptoms: difficulty breathing, swelling in your face, lips, tongue or throat.
Infigratinib can cause serious side effects. If you experience:
- Eye pain or discomfort
- Vision changes
- Redness, swelling, blisters, or pain on your palms or soles
- Numbness or tingling in the mouth area
- Muscle cramps
- High calcium levels can cause confusion, fatigue, nausea, and vomiting. Other symptoms include loss of appetite or increased thirst, constipation, or increased urination.
- Low blood cell counts: fever; chills; skin and mouth sores. Easy bruising. Unusual bleeding. Pale skin. Cold hands and feet. Feeling light-headed.
If you experience certain side effects, your cancer treatment may be halted or delayed.
Infigratinib can cause the following side effects:
- Dry eyes and blurred vision
- Redness or tenderness of the hands or feet
- Dry skin, changes in eyelashes, hair fall
- Problems with your nails or fingernails
- You may experience changes in taste and smell, dry mouth, or mouth sores.
- Constipation, diarrhea, and stomach pain are all symptoms of constipation.
- Feeling tired or weak
- Joint Pain
- Low blood cell count, high calcium, or other abnormal lab test results
There may be other side effects. Call your doctor for medical advice about side effects. To report side effects, you can contact the FDA at 1-800-FDA-1088.
Similar/related drugs
Durvalumab, Imfinzi, Ivosidenib, and Tibsovo
Warnings
Use exactly as directed on the package and label. Please follow the instructions on the package and label.
Before you take this drug
Tell your doctor about any of the following:
- You may have problems with your vision or eyes.
- Liver disease
- Kidney disease is a serious condition.
Before starting the treatment, you may need to take a pregnancy test.While using this medication and for 1 month following your last dose, use birth control.Do not breastfeed for 1 month after the last dose of this medication.
How to take Infigratinib?
Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Infigratinib will be given to you in a 28-day treatment cycle. You'll only take it on certain days.Do not eat for at least an hour or two hours before you take the pill.
Take your medicine every day at the same time.Do not open, crush, chew, or break the capsule. Swallow it whole. Take the capsule with a glass of water.Do not take a second dose if you vomit soon after taking infigratinib. Do not miss your next scheduled dose.
You may require frequent vision tests. If you suffer from dry eyes, you may need to use artificial tears or eye gels that lubricate the eye.Store the blister packs at room temperature, away from moisture or heat.
Details on dosage
Adult dose for cholangiocarcinoma biliary tract:
Orally, take 125mg (one 100mg capsule and one 25mg capsule) once daily for 21 days with 7 days off on a 28-day cycle.
Comments:
Continue treatment until the disease progresses or there is unacceptable toxicity.
Selecting patients for treatment of locally advanced or metastatic cholangiocarcinoma that is unresectable based on the presence or absence of FGFR2 fusions or rearrangements.
Information on FDA-approved test(s) for the detection of FGFR2 fusions or rearrangements in cholangiocarcinoma is available at: http://www.fda.gov/companiondiagnostics.
Use: To treat adults with unresectable, locally advanced, or metastatic cholangiocarcinoma that has been previously treated and is not resectable. The cancer may have a fusion of the fibroblast growth factor receptor 2 (FGFR2) or another rearrangement detected by an FDA-approved test.
What happens if I miss the dose?
If you miss a dose by more than four hours, you should use the medication as soon as possible. Never take two doses of the same medicine at once.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Grapefruit can interact with infigratinib, causing side effects. Avoid consuming grapefruit products.Avoid taking antacids within 2 hours of taking infigratinib.
Interaction with other drug
It is sometimes not safe to take certain medications together. Some drugs may affect the blood levels of drugs that you are taking, increasing side effects or making them less effective.You can take infigratinib 2 hours before or after taking a "H2 blocker", stomach acid medication. These include cimetidine (famotidine), nizatidine (ranitidine), Pepcid, Tagamet, and Zantac.
Inform your doctor if you are taking any medications to reduce stomach acids. Tell your doctor about any medicines you take to reduce stomach acid.Infigratinib can be affected by other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the other medications you take.