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Generic name: ertugliflozin and metformin [ER-too-gli-FLOE-zin-and-met-FOR-min]
The class of drugs: antidiabetic combinations

What is Segluromet?

Segluromet is a mixture comprising ertugliflozin as well as metformin, which help control your blood sugar. Ertugliflozin helps the kidneys eliminate glucose from the bloodstream. Metformin helps the liver release less sugar into the bloodstream.

Segluromet can be used in conjunction with exercise and diet to help improve blood sugar control for people suffering from type 2 diabetes mellitus.Segluromet isn't a cure for type 1 diabetes.


It is not recommended to use segluromet in the case of an extreme kidney condition, especially if you are on dialysis or if you suffer from diabetes ketoacidosis.Ertugliflozin could increase the chance of lower leg amputations, particularly if you've suffered a previous foot ulcer, amputation, heart disease, circulation issues, or nerve injury.

If you are required to undergo any kind of x-ray or CT scan that uses the injection of a dye into the veins of your body, you might require a temporary stop of Segluromet.Ertugliflozin may cause serious infections of the vagina or penis. Get medical help immediately if you experience burns, an itching smell or discharge, pain, swelling, redness, tenderness of the rectal or genital region, fever, or do not feel well.

It is possible to suffer from a condition known as lactic acidosis. It is an extremely dangerous accumulation of lactic acid in your blood. Seek medical attention immediately when you experience even the smallest symptoms, like unusual muscle pain, numb or cold sensations in your legs and arms, or chest nausea, vomiting, and pain, or diarrhea, an irregular heartbeat, and dizziness. You may also feel extremely tired or weak.

Similar/related drugs

Ozempic, Mounjaro, metformin, Trulicity, Lantus, Victoza, and Levemir

Prior to use this drug

Segluromet is not a good choice for you. Segluromet: If you have an allergy to metformin or ertugliflozin or if you suffer from

  • Serious kidney condition (or if you're taking dialysis)
  • Diabetes ketoacidosis (call your doctor to seek treatment)

If you require any kind of x-ray or CT scan that uses an injection of dye in your veins, then you might need to temporarily stop using this medication.

Ertugliflozin can increase the chances of having a lower leg amputated, in particular if you've suffered a previous foot ulcer, amputation, or heart condition circulation issues, as well as nerve injuries.

To ensure Segluromet is safe for you, ask your physician if you've previously had:

  • Heart issues;
  • A diabetic foot ulcer or amputation
  • Nerve problems or circulation issues in your feet and legs
  • Kidney or liver disease;
  • High levels of ketone concentrations in your urine or blood;
  • Bladder infections and other urination issues;
  • Low blood pressure;
  • Issues with your pancreas that may require surgery
  • If you regularly drink alcohol, you are a frequent drinker.
  • If you are following an eating plan that is low in salt,

It is possible to be diagnosed with an illness called lactic acidosis. This is an extremely dangerous accumulation of lactic acid in your blood. It's more likely if you suffer from any other medical condition or a serious disease, such as chronic alcoholism, or are older than 65. Talk to your doctor about the risks.

Follow the instructions of your physician regarding the use of segluromet if you're expecting. Blood sugar control is essential during pregnancy. Your dosage requirements may differ in each trimester of pregnancy. High blood sugar levels can cause problems for pregnant women and children.It is not recommended to take segluromet in the third or second trimester of pregnancy.

Metformin can stimulate ovulation in premenopausal women and increase the chance of an unplanned pregnancy. Consult your physician about the risks.It is not recommended to feed your baby while taking this medication.Segluromet is not a drug that has been approved to be used by anyone younger than 18 years of age.

How to take Segluromet?

Segluromet is generally taken two times every day, in conjunction with meals. Follow the instructions on the label of your prescription and study all medication guides or instructions sheets. The doctor might alter your dosage.Segluromet is most effective if you consume it in conjunction with food.Contact your physician if you are suffering from nausea or diarrhea, if you eat less fluid or food than normal, or if you're sweating more frequently than normal.

Your blood sugar level will have to be monitored regularly. Also, you might need to test the amount of ketones in your urine. Segluromet may cause life-threatening ketoacidosis (too high levels of acid in the blood). Even if the blood sugar level is normal, consult your physician in the event that a urine t est confirms ketones are present in your urine.

There is a possibility that you may experience insufficient levels of blood sugar (hypoglycemia) and experience extreme hunger, dizziness, and confusion. You may also feel irritable, angry, and shaky. To treat hypoglycemia quickly, take a snack or drink a rapid-acting sugar source (fruit juice crackers, hard candy raisins, or other non-diet beverages).

The doctor might prescribe an injection kit of glucagon for those suffering from severe hypoglycemia. Make sure that your family members or close family members know what to do with this injection in the event of an emergency.Be aware of indications of the presence of high levels of blood sugar (hyperglycemia), like more thirst or frequent urination.

The blood sugar levels may fluctuate due to stress or illness, surgical procedures, exercise, drinking, or eating infrequently. Consult your physician prior to altering your dosage of medication schedule.This medication can cause unexpected results in certain laboratory tests. Inform any physician who treats you that you're taking Segluromet.

Segluromet is just one component of a comprehensive treatment plan, which could also comprise diet exercises, weight loss, regular blood sugar tests, and medical treatment. Follow the directions of your doctor carefully.Your physician may recommend that you take an additional dose of Vitamin B12. Only take the amount of vitamin B12 your doctor has ordered.Store segluromet at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose of Segluromet for Diabetes Type 2:

Make a dose that is individualized based on your current regimen.
The first dose is 1 tablet taken orally, every day, twice.
For patients taking metformin, start by taking tablets with Ertugliflozin 2.5 mg. One-half of the total dosage of daily metformin
For patients who are taking ertugliflozin Start with a tablet containing one-half daily doses of metformin and ertugliflozin 500 mg.
For patients already receiving metformin and ertugliflozin: Begin by taking a tablet that gives one-half of the total daily dose of ertugliflozin and one-half of similar regular doses of metformin.
Dosage adjustments based on efficacy and tolerance
Maximum dose for the day: Ertugliflozin 15 mg; Metformin 2000 mg
The depletion of volume should be addressed prior to the initiation of therapy.
The dosage of metformin should gradually increase to lessen the gastrointestinal side effects. Consuming it before meals can also help reduce digestive effects.
This drug is not suitable for patients suffering from type 1 diabetes mellitus. It is also not recommended to treat ketoacidosis in diabetics.
Use: As an addition to exercise and diet to increase glycemic control in adult patients with type II diabetes mellitus that are not sufficiently controlled by a treatment that includes metformin or ertugliflozin, or in patients already being treated with metformin and ertugliflozin.

What happens if I miss the dose?

The medication should be taken in the shortest time possible. Be sure to avoid missed doses that are close to the date for the following dose. Don't take two doses in one go.

What happens if I overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help Line at 1-800-222-1222. An overdose can cause lactic acidosis.

What should be avoided?

Beware of drinking alcohol. It reduces blood sugar levels and can increase the chances of lactic acidosis.Do not get up too quickly from a lying or sitting position, as you could be dizzy.

Side effects of Segluromet

Take immediate medical attention. If you show symptoms of an allergy reaction Segluromet: hives, breathing problems, and swelling of your lips, face, and tongue.

You should seek medical attention as soon as you begin to notice the symptoms of a genital illness (penis or vagina): burning, itching, discharge, odor, pain, tenderness, swelling, or redness in the rectal or genital region, and fever, as well as a feeling that you are not well. These symptoms can worsen rapidly.

See your doctor right away. If you suffer from:

  • New tenderness, pain, ulcers, sores, or infections of your feet or in your legs;
  • Minimal or no urination
  • Acidosis lactica: muscle pain that is unusual and breathing problems stomach pain, vomiting, irregular heartbeat, dizziness, feeling cold, tired, or weak
  • Ketoacidosis (too excessive acidity in the blood): nausea, stomach pain, vomiting disorientation, unusual drowsiness, or difficulty breathing;
  • Symptoms of dehydration such as dizziness, weakness, and feeling lightheaded (like you're about to faint)
  • Indications of a bladder infection Burning or pain whenever you go to the bathroom, more urine output, blood in your urine, and fever, as well as discomfort in your pelvis or back.

Certain adverse reactions are more likely to be experienced by older adults.

Common Segluromet side effects can be:

  • Genital yea st infection;
  • Stomach discomfort;
  • Nausea, vomiting, diarrhea, gas;
  • Headache and weakness;
  • Urinating more frequently than normal

This isn't an exhaustive list of possible side effects, and other effects may also be present. Consult your physician for advice regarding medical adverse effects. It is possible to report any adverse allergic reactions or symptoms to FDA via 1-800-FDA-1088.

Interaction with other drugs

If you decide to stop or start using segluromet, your doctor will have to alter the dosages of other diabetes medications you take regularly.

Other drugs can be incompatible with metformin and ertugliflozin, such as prescription and over-the-counter medicine, vitamins, and herbal products. Discuss with your doctor all the medicines you are currently taking as well as any medications you are about to start or stop taking.