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Name of the generic: histrelin (implant) (implant) his-TREL-in in
Names of brands: Supprelin LA, Supprelin Vantas
Dosage form: subcutaneous implant (50 mg)
Drug classes: gonadotropin-releasing hormones, hormones, and antineoplastics

What is Histrelin?

Histrelin stimulates the body's production of specific hormones and causes the production to stop temporarily.

Supprelin LA, the Supprelin version of the histrelin brand, can be employed to address premature puberty in male and female kids who are at least two years old.

There is a Vantastreattohistrelin that version of the drug histrelin can be used for treatment of the symptoms associated with prostate cancer in men. Vantas is a treatment for prostate cancer; however, it does not treat the cancer itself.

Histrelin is also employed for other purposes that are not covered in this guideline.

Side effects of Histrelin

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such ashives,breathing, difficulty breathing; hives and swelling of your lips, face, tongue, throat, or face.

Histrelin can cause severe adverse effects. Consult your physician immediately if you suffer from:

  • bones pain, numbness, or weakness in the feet or legs;
  • hard or painful urine; bloody urine;
  • a seizure;
  • an increase in pressure within the skull, causing severe headaches, ringing of your ears, dizziness, nausea, and vision issues, or headaches behind your eyes or
  • mental disorders: crying spells, anger, and feeling irritable or restless.

Common side effects of histrelin include:

  • constipation;
  • Problems with urination;
  • breast swelling;
  • Hot Flashes;
  • being tired;
  • Erectile malfunction (impotence): reduced size of the testicle; or
  • bruises, redness, pain, swelling, pain, or irritation at the site where the implant was placed.

This isn't an exhaustive list of all the side effects. Other side effects could be present. Contact your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar/related drugs

Estradiol, Tamoxifen, Premarin, Xtandi, Zytiga, Casodex, and Leuprolide


Histrelin may harm an unborn child or cause miscarriages. Do not take it if you are expecting.

Histrelin may cause adverse effects like angry spells, crying, or aggression, as well as being irritable or restless. Consult your physician if you are experiencing any new or deteriorating mental health issues.

Before you take this drug

You shouldn't be treated with histrelin if you are sensitive to it or with similar hormone treatments like leuprolide, nafarelin, ganirelix, Eligard, Lupron, Viadur, and others.

Do not take histrelin when you are expecting. It could harm the baby's unborn child or trigger a miscarriage. Make sure you use effective methods of birth control to avoid pregnancy. Also, notify your doctor as soon as possible when you find yourself pregnant.

Vantas are not recommended for children or women.

To be sure that the drug Supprelin LA is suitable for you, inform your doctor if you have ever experienced:

  • psychosis, also known as schizophrenia;
  • epilepsy or a different seizure;
  • A brain tumor or blood vessel disorder in your brain
  • when you are taking a drug that could trigger seizures (such as an antidepressant).

To be sure Vantas is safe for you, inform your doctor if you previously had:

  • an obstruction in the bladder or other urinary problems;
  • diabetes;
  • heart-related problems, heart attack stroke, or stroke;
  • Long QT syndrome (in either you or a relative);
  • Low bone mineral density (osteoporosis) Or
  • a condition affecting your spine.

It is not recommended to breastfeed while taking this medication. Consult your physician regarding any risks.

Supprelin is not to be used by a child under 2 years of age. Vantas cannot be a product that is approved to be used by anyone younger than 18.

What is  histrelin?

Histrelin is an implant that is tiny and placed under the skin inside your arm's upper. The implant will be inserted through a minimal surgical procedure in a medical clinic or office.

It is recommended to insert the implant in an arm that is not your dominant arm (your left arm if you have a right hand). Make sure to inform your physician which arm you use the most often.

The skin on your upper arm is treated using a numbing medication to prevent your arm from causing pain when the implant is inserted. The doctor will employ a scalpel to make an incision small enough where implants will be placed.

The histrelin implant will be inserted using a specially designed tool that inserts the implant through an incision within the skin. Following the injection and then removing the tool for insertion, your doctor will examine your arm to make sure that the implant is correctly positioned.

The cut in your skin could be closed using stitching or surgical strips. Follow the instructions of your physician for taking care of the wound and ensuring it is kept bandaged and clean until it is healed completely. Make sure your arm is dry for a minimum of 24 hours.

Most likely, you'll be capable of feeling the implant under the skin, but it shouldn't cause discomfort or pain.

Contact your physician if you notice any swelling, pain, or tenderness—itching, bruising, tingling, or redness—in the area where the implant was put and if it slips through your skin or disappears.

An implant made of histrelin is typically kept in place for 12 months. It is then removed using a surgical incision. Do not attempt the removal of the implant on your own. Your doctor will decide if you require another implant as a continuing treatment.

You might experience a temporary rise in precocious puberty signs for up to a week after receiving Supprelin LA. Supprelin LA implant

You might require medical tests to assist your doctor in determining the length of time you should be treated with histrelin.

Histrelin may cause abnormal results when testing for certain medical conditions. Be sure to inform any doctor treating you about using histrelin.

Details on dosage

Usual Adult Dose for Prostate Cancer:

One 50-mg capsule is placed subcutaneously within the inner part of the upper arm.
Time of treatment The implant should be removed at the end of 12 months.
Note: The implant was designed to provide some additional weeks of drug release (to permit flexibility in appointments with a doctor). If the implant is removed, an additional implant can be inserted to maintain treatment.

Vantas: palliative therapy for prostate cancer that is advanced

Usual Pediatric Dose for Precocious Puberty:

2 years or older:
One 50 mg tablet is inserted subcutaneously within the inner part of the upper arm.
Treatment duration The implant should be removed at the end of 12 months.
Note: If the implant has been removed, a new implant can be inserted for continued therapy.

Discontinuation of treatment should be determined at the sole discretion of the doctor and at the right time for the onset of the puberty stage (approximately eleven years for females and twelve years for men).

Supprelin LA: Management for Children Who Have Central Precocious Puberty

Do I be concerned if I miss a dose?

Since histrelin can be given in the form of an implant, it will not follow a daily dose schedule.

for moreThe implant shouldn't remain in your arm longer than 12 months. Contact your physician when it's time for the implant to come out.

What will happen if I take excessively?

Because the histrelin implant has certain amounts of medication, you aren't likely to get an overdose.

What should be avoided?

At least seven days following the day your implant is placed, refrain from strenuous exercise or lifting heavy weights.

Interaction with other drugs

Other drugs can also alter histrelin's function, including medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor all the medicines you are currently taking as well as any medications you are about to start or stop taking.