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Entyvio

Pronunciation in Tiveee Oh
Generic name: vedolizumab [VE-doe-LIZ-ue-mab]
Formulation for dosage: intravenous infusion
Drug class: selective immunosuppressants

What is Entyvio?

Infusions of Entyvio are prescribed to people suffering from ulcerative colitis (UC) or Crohn's disease that is moderate to severe. Entyvio prevents the accumulation of white blood cells circulating through the digestive tract (intestine), which can help manage inflammation and symptoms of Crohn's disease. It targets the intestine to reduce inflammation, but it does not typically result in systemic immune suppression.

Entyvio is a treatment for active disease. It could help keep Crohn's disease symptoms under control for a long time. Entyvio could also help reduce the need for steroid medications by reducing the symptoms over time.Entyvio was approved as an FDA-approved drug on May 20, 2014. Entyvio's indications range from mild to severe ulcerative colitis (UC) or Crohn's disease in adults. None of the biosimilars of vedolizumab has been approved by the FDA.

Entyvio (vedolizumab) is a member of the class of drugs known as integrin receptor antagonists. It is also known as an immunosuppressant selectively as well as a monoclonal antigen. Entyvio's action mechanism and the way it functions by binding to A4b7's Integrin located on the outside of a specific type of white blood cell known as memory T-lymphocytes A4b7 integrin's binding blocks it from interfacing with MAdCAM-1 (mucosal addressin cell adhesion molecule-1). This interaction plays an important part in the development of chronic inflammation in patients suffering from IBD.

Side effects of Entyvio

Common adverse effects of Entyvio

The most frequent adverse effects of Entyvio can be described as:

  • Sore throat and fever symptoms of the flu
  • signs of a cold like sinus pain, a stuffy nose, or sneezing;
  • cough, mucus, and shortness of breath. chest discomfort
  • the pain in your arms and legs;
  • tiredness;
  • headache, joint pain, back pain;
  • itching, or vomiting.

Very serious side effects from Entyvio

See a doctor immediately. If you are experiencing symptoms that you are experiencing an allergic reaction due to Entyvio, such as hives, difficulty breathing, or swelling of your lips, face, and tongue,

There are some side effects that can happen when you inject. Contact your physician if you are feeling faint, nauseated, dizzy, or sweaty. or if you experience headaches, chest tightness, back discomfort, breathing difficulties, or a swelling on your face.

Vedolizumab could cause a severe brain infection, which can cause disability or even death. Contact your physician immediately if you are experiencing difficulties with speech, thinking, vision, or movement. These symptoms may begin gradually and become more severe.

Contact your doctor immediately. If you suffer from:

  • Chills, fever, body aches, fever, and flu-like symptoms; throat and mouth skin sores; ulcers;
  • Discomfort, achiness, swelling, or pussy-oozing around the area of your anal;
  • Nausea, nausea, vomiting, vomiting, severe diarrhoea, nausea, vomiting, severe diarrhoea that is bloody or watery; abdominal cramps; losing weight;
  • Cough, pain while swallowing, or
  • Liver issues nausea, abdominal pains, itching, fatigue, and loss of appetite. dark urine, stools that are clay-coloured, and  jaundice (yellowing of the eyes or skin).

There isn't an exhaustive list of the possible consequences, as other effects may occur. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Warnings

Entyvio can trigger severe adverse effects on your liver or brain and cause a disease. Call your doctor immediately if you notice fatigue, fever, muscle pains, irritation of the throat and breath shortness, skin sores, pain in the urine, nausea, or stomach pain. dark urine or yellowing of your skin and eyes. You may also experience issues with your thinking, speech, vision, or muscle movement.

Inform your doctor in the event that you experience any reaction from the injection, including the feeling of dizziness, nausea, itching headaches, chest tightness, difficulty breathing, or swelling on your face.

Don't get a "live" vaccine while using Entyvio.

Before you Take this Drug

It is not recommended to use Entyvio if you are allergic to vedolizumab.

To ensure that Entyvio is suitable for you, ask your doctor if you've ever experienced:

  • An active or recent ailment;
  • Liver disease;
  • Indications of infection like cough, fever, or flu-like symptoms;
  • If you're planning to have any vaccinations.

Inform your doctor if you have ever been diagnosed with tuberculosis or if someone in your family is suffering from tuberculosis. Tell your doctor if you've recently been on a trip. Fungal infections and tuberculosis are more common in particular areas of the globe, and you may have been exposed while travelling.

You must be up-to-date with all vaccines prior to getting Entyvio.

Pregnancy

Inform your physician if you are pregnant or planning to be pregnant. If you have active ulcerative colitis or Crohn's disease symptoms during pregnancy, it could increase the risk of having a baby prematurely born or the baby's weight being too low. The benefits of treating these ailments may outweigh the risks for the child.

If you take Entyvio while pregnant, ensure that any physician who is caring for your newborn baby understands that you took the medication during your pregnancy. Being exposed to vedolizumab during pregnancy could alter your baby's vaccination schedule in the first few months of his life.

If you're pregnant and you are a registered mother, your name could be included on the pregnancy registry to monitor any effects of the drug vedolizumab on the infant.

Breastfeeding

Inform your doctor if you are nursing or planning to breastfeed. Entyvio passes into your breast milk. Discuss with your healthcare professional the best way to feed your child when you are taking this medication.

How to Take Entyvio?

Entyvio is administered as an injection into a vein, typically every 2–8 weeks. The healthcare professional will give the injection.

Before starting treatment with Entyvio, your physician may run tests to confirm you are not suffering from tuberculosis or any other infection.This medication should be administered slowly, and the infusion may last for at least 30 minutes.

You will be closely monitored for a short period of time following receiving Entyvio to ensure that you don't suffer from an allergic reaction.It could take some weeks before your symptoms begin to improve. Continue to take the medication as prescribed and notify your physician if you don't improve within 14 weeks after treatment.

Details on Dosage

Usual Adult Dose for Crohn's Disease

  • 300 mg IV in 30 minutes during Weeks 0, 2, and 6, after which it is repeated every 8 weeks after that.

Usual Adult Dose for Ulcerative Colitis:

  • 300 mg IV for 30 minutes during Weeks 0, 2, and 6, after which it is repeated every 8 weeks following that.

Comments:

  • Prior to starting treatment, patients must be updated on all vaccinations as per the current guidelines for immunisation.
  • There is no proof of therapeutic benefit before Week 14.

Uses:

  • Adult Ulcerative Colitis (UC): Adults suffering from moderately to highly chronic ulcerative colitis This drug is employed to maintain and induce the clinical response or remission, improve the appearance of endoscopic images of the mucosa, or achieve an untreated remission with no corticosteroid.
  • Adult Crohn's Disease (CD): Adults suffering from moderate to severe chronic Crohn's disease The drug is used to achieve a clinical response, i.e., remission without corticosteroids.

What Happens If I Miss a Dose?

Contact your doctor for advice. If you do not make an appointment to receive the injection of Entyvio,

What Happens If I Overdose?

Since the medicine is prescribed by a medical specialist in a medical setting, the risk of overdose is less likely to occur.

What Should be Avoided?

Don't receive a "live" vaccine while using Entyvio. Avoid getting in contact with anyone who has recently been exposed to a live vaccine. There is a possibility that the virus will be transmitted to you. The live vaccines are measles, rubella, mumps (MMR), and rotavirus. yellow fever, typhoid, varicella (chickenpox), zoster (shingles), and respiratory flu (influenza) vaccines.

You could be able to receive "killed-virus" vaccines such as an influenza vaccination, the polio vaccine, the rabies vaccine, or the hepatitis A vaccine. Consult your physician prior to getting any vaccines if you are receiving treatment with Entyvio.

Avoid being around those with illnesses or who suffer from infections. Inform your doctor immediately when you begin to show symptoms of an infection.

Interaction with Other Drugs

Inform your doctor about any other medications you take, particularly:

  • Natalizumab;
  • Medications to treat the symptoms of psoriasis or rheumatoid arthritis medications to treat rheumatoid arthritis or psoriasis Etanercept or golimumab
  • Other medications to treat Crohn's disease and ulcerative colitis other medications to treat Crohn's disease or ulcerative colitis, like adalimumab and certolizumab; infliximab; as well as
  • Other medications that weaken the immune system, such as steroids, cancer medicines, and medications to stop rejection of organ transplants.

This list isn't complete. Other drugs can interfere with vedolizumab, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Some interactions with drugs are not listed here. are listed here.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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