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Eliquis

Generic Name: Apixaban [a-PIX-a-ban]
Drug Class: Factor Xa inhibitors

What is Eliquis?

Eliquis inhibits the action of clotting agents in the blood.Eliquis can be used to reduce the possibility of stroke or blood clots in those who suffer from a heart rhythm problem known as atrial fibrillation.

Eliquis decreases the likelihood of developing an artery clot that can be found in the lungs and legs of those who've recently undergone knee or hip replacement surgery.Eliquis helps to treat blood clots that have formed in the veins in the leg (DVT, or deep vein thrombosis) or in your lungs (pulmonary embolism) to reduce the chance of them happening in the future.

Warnings

Eliquis raises your chance of fatal or severe bleeding, in particular if you are taking certain drugs simultaneously (including the many over-the-counter medicines). It's crucial to inform your physician of any medications you've recently taken.

Contact your physician immediately if you notice symptoms of bleeding, such as swelling, pain, feeling faint or dizzy, bleeding gums, nosebleeds, or nasal bleeding; a heavy menstrual cycle or unusual vaginal bleeding; bloody urine as well as bloody or tarry stool; coughing blood up; vomiting that resembles coffee grounds; or bleeding that doesn't stop.

Eliquis must be discontinued 24 to 48 hours before any surgery or procedure that is invasive, as well as dental procedures. Let your dentist know if you are using Eliquis.

Eliquis could cause a severe blood clot in the spinal cord, which could cause permanent or long-term paralysis. This kind of blood clot may develop during an MRI or the use of spinal anaesthesia (epidural), particularly in the case of a genetic defect in the spinal cord, if you're using an intra-articular spinal catheter, if you've undergone spinal surgery, or multiple spinal taps, or when you are usingDrugs that may alter the blood's clotting

Eliquis could cause a severe blood clot to the spinal cord when you are treated with an examination for a spinal tap or some form of spinal anaesthesia (epidural), in particular when you suffer from an inherited spinal deformity or have an implanted spinal catheter, if you have a history of having surgery on your spine or multiple spinal taps, or if you're employing other medicines that influence the blood clotting process. This kind of blood clot may result in permanent or lengthy paralysis.

Contact a medical professional immediately. If you are suffering from signs of a spinal cord blood clot like back discomfort and numbness, weakness in your lower part of the body, or a loss of bowel or bladder control,Stop using Eliquis unless your physician tells you to. A sudden stop can raise your chance of a blood clot or stroke.

Before you Take this Drug

It is not recommended to take Eliquis in the event that you have an allergy to apixaban or there is active bleeding due to injuries, surgeries, or any other reason.

Eliquis can cause you to be more prone to bleeding, especially when you suffer from bleeding disorders that are due to genetics or a cause of the disease.

Discuss with your doctor if you are using an artificial heart valve or have been through:

  • Issues with bleeding;
  • Antiphospholipid syndrome, in particular when you've had three positive antibodies
  • Kidney or liver disease

Eliquis may cause a severe blood clot in your spinal cord if you have an examination for a spinal tap or a spinal injection (epidural). The blood clot could result in permanent paralysis. This is more likely to happen in the following situations:

  • You have a spinal catheter installed or one was removed recently.
  • You have had the procedure, or multiple cervical taps.
  • You have recently had an epidural tap or a spinal tap under anaesthesia.
  • That you are taking or any different NSAIDs (nonsteroidal anti-inflammatory medications) that you are taking, such as ibuprofen (Advil, Motrin) or naproxen (Aleve), diclofenac, indomethacin, or meloxicam, and other NSAIDs;
  • You are taking other medications to prevent or treat blood clots.

The use of Eliquis can increase the risk of bleeding if you're expecting or during delivery. Consult your physician if you are planning to get pregnant.Don't breastfeed.

How to Take Eliquis?

You should take Eliquis exactly as recommended by your physician. Be sure to follow the directions printed on the prescription label. Also, review all drug guides and instruction sheets. The doctor might change the dose you take.It is possible to consume Eliquis in combination with or without meals.If you can't take in a tablet completely, then crush it and mix it with the apple juice, water, or applesauce. Take the mix in a single swallow without chewing.

A tablet-crushed mixture can be administered via the nasogastric (NG) tube for feeding. Be sure to read and follow the instructions that are included with the medication.Eliquis could stop bleeding in the event of a minor incident. Seek medical attention in the event that you are bleeding and it does not cease.Inform your physician if you are planning an operation or dental procedure. There is a possibility that you will have to discontinue the use of Eliquis for a limited period of time.

Don't discontinue using Eliquis unless your doctor advises that you should.If you cease using Eliquis in any way, the doctor would prescribe a different medicine to avoid blood clots.Keep at room temperature, away from heat and humidity.

Details on Dosage

Usual Adult Eliquis Dose for Deep Vein Thrombosis—Prophylaxis:
2.5 mg, taken by mouth twice daily
The duration of treatment:
Hip replacement time: 35 days
Replacement of the knee: 12-days
Notes: The first dose is to be taken between 12 and 24 hours following the procedure.
Treatment: preventive treatment for DVT and the possibility of it leading to the development of pulmonary embolism (PE) in those who've undergone knee or hip replacement surgery.
RECURRENT DVT AND PE RISK REDUCTION:
2.5 mg, taken by mouth twice a day.

Normal Adult Dose Eliquis to Treat Deep Vein Thrombosis Prophylaxis Following Hip Replacement Surgery:
2.5 mg taken orally, twice daily
Therapy duration:
The replacement of the hip takes 35 days.
The replacement for the knee is 12-days
Commentary: The first dose is recommended to be administered within 12–24 hours of the surgery.
Utilisation: Prevention of DVT that could lead to an embolism in the pulmonary vein (PE) in those who've undergone knee or hip replacement surgery
RECURRENT DVT AND PE RISK REDUCTION:
2.5 mg, taken by mouth twice a day.

Adult Dose of Eliquis for Deep Vein Thrombosis Prevention Following Knee Replacement Surgery:
2.5 mg, taken by mouth twice a day
Therapy duration:
Hip replacement time: 35 days
Replacement of the knee: 12-days
Commentary: The first dose is recommended to be administered within 12–24 hours of the surgery.
Treatment: Preventive treatment for DVT that could lead to an embolism in the pulmonary vein (PE) for those who've undergone knee or hip replacement surgery
RECURRENT DVT AND PE RISK REDUCTION:
2.5 mg taken orally, twice per day.

5 mg orally, 2 times daily
The use of this medication reduces the chance of stroke as well as systemic embolism in patients suffering from nonvalvular atrial fibrillation.

Usual Adult Dose of Eliquis for Thromboembolic Stroke Prophylaxis:

5 mg taken orally twice per day
The use of this medication reduces the chance of stroke as well as systemic embolism in patients suffering from nonvalvular atrial fibrosis.

Adult Dose for Deep Vein Thrombosis:

The first dose is 10 mg, taken orally two times per day for seven days.
Maintain a dose of 5 mg oral 2 times per day.
Treatment: treating deep vein thrombosis as well as embolisms in the pulmonary system

Usual Adult Dose for Pulmonary Embolism:

The first dose is 10 mg, taken orally twice per day for 7 days.
Maintain a dose of 5 mg taken orally two times per day.
Utilisation: Treatment for deep vein thrombosis as well as embolisms in the pulmonary system

What Happens If I Miss a Dose?

You can take the dose you missed at the exact time you recall the dose. The next dose should be taken according to the normal time and adhere to your daily routine. Avoid taking two doses simultaneously.

Make sure you refill your prescription before you're out of Eliquis completely.

What Happens If I Overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help line at 1-800-222-1222.

What Should be Avoided?

Beware of activities that could make you more susceptible to bleeding or injuries. Be extra careful when cutting or brushing your teeth.

Side effects of Eliquis

Take immediate medical care. If you exhibit symptoms that indicate an allergy, Eliquis: hives or chest pains, wheezing, difficulty breathing, light-headedness, and swelling on your lip, face, tongue, or throat.

Get medical help immediately when you notice signs of the presence of a blood clot in your spinal region, like tingling, muscle weakness, or numbness, particularly in your legs or feet.

See your physician right away. If you suffer from:

  • Simple bruising, abnormal bleeding (nose, mouth, tongue, vagina, or rectum), bleeding due to wounds or injections, or any bleeding that won't stop;
  • Menstrual bleeding that is heavy;
  • Headache, dizziness, and weakness. It's like you've passed out.
  • Urine that appears to be either pink, red, or brown.
  • Bloody or black stools and coughing blood. Vomit that looks like the appearance of coffee grounds.

It isn't a comprehensive list of possible side effects, and there are other possible side effects. Contact your doctor to get medical advice regarding adverse effects. The best way to report adverse reactions is to call the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

There are times when it's not recommended to take certain drugs simultaneously. Certain drugs may affect the blood levels of other drugs that you use, and this could cause more side effects or render your medications less effective.

Other medications (including many over-the-counter medicines) could increase the chance of having blood or bleeding clots. Talk to your doctor about any medications you've recently taken, especially:

  • Other medicines that help or stop blood clots
  • An anticoagulant like heparin as well as warfarin (Coumadin, Jantoven);
  • An antidepressant
  • Aspirin, or any other NSAID (nonsteroidal anti-inflammatory drug) that is used for a long time.

This is not a complete list, and a variety of other medications could be incompatible with APIXABAN. It includes over-the-counter and prescription medications, vitamins, and herbs. There are many possible interactions between drugs. can be listed in this list.

DRUG STATUS

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Prescription only

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