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Generic name: progesterone vaginal [proe-JESS-te-rone-VAJ-in-al]

Drug class: progestins

What is Endometrin?

Endometrin is a vaginal implant with 100 mg of progesterone. Progesterone is a hormone for females that is essential for the menstrual cycle and ovulation. Progesterone triggers changes to the inner lining of your uterus, which makes it simpler for a fertilized egg to connect to your uterus during the beginning of the pregnancy. Progesterone helps the body keep the pregnancy going.Endometrin is commonly used in the treatment of fertility as part of assisted reproduction technology (ART) to help women who are not able to become pregnant due to the absence of progesterone, a hormone that is naturally present within the body.Endometrin is also employed for reasons not mentioned in this guideline for medication.

Side effects of Endometrin

Take immediate medical attention. If you are experiencing symptoms that you are experiencing an allergic reaction due to the hormone endometrin, symptoms include hives, trouble breathing, or swelling of your lips, face, and tongue.

Contact your doctor immediately. If you suffer from:

  • Abnormal vaginal bleeding;
  • Discomfort or burning sensation after you urinate;
  • Signs of depression (sleep issues, fatigue, and mood swings);
  • A breast lump
  • Suddenly experiencing vision problems and severe headaches or pain in your eyes;
  • Heart attack symptoms: tension or chest discomfort; a throbbing pain that extends into your shoulder or jaw; nausea, sweating, or vomiting;
  • Liver disorders: nausea, upper stomach discomfort, itching, fatigue, decreased appetite black stools, dark urine, and jaundice (yellowing of the eyes or skin);
  • Indications of a stroke - the sudden feeling of weakness or numbness (especially on the opposite side); an abrupt, intense headache; slurred speech; or issues with balance or speech;
  • Symptoms for a blood clot inside the lungs: chest pain, a sudden cough and wheezing, rapid breathing, coughing up blood, or
  • Symptoms that a blood clot has formed within your leg: discomfort, swelling, heat, or redness in either leg or the other.

Common side effects of endometrin include:

  • Dizziness, confusion, drowsiness, and tiredness;
  • Headache, mood swings, and feeling anxious or angry;
  • Stomach pain, nausea, diarrhea, and constipation;
  • Swelling, bloating, or bloating in your feet or hands;
  • The breast, swelling, or tenderness in the breasts;
  • Cramps, pelvic pain,
  • Burning, vaginal itching, or discharge.

This list is not comprehensive and other possible side effects could occur; to get advice from a physician regarding any medical effects or report side effects to FDA at 1-800-FDA-1088, call them directly and report.


The use of endometrin is not recommended when you have an underlying stroke, blood clots, circulation issues, liver diseases, breast cancer, abnormal vaginal bleeding, or if you've recently experienced an abortion in the tubal area or an unfinished abortion.If used in conjunction with fertility treatment, endometrin could be administered for as long as 10 weeks after the beginning of a pregnancy. The timing of your dose is crucial for this medication to work. Be sure not to skip any doses.Endometrin may cause negative side effects that could affect your reactions or thinking. Be cautious if you drive or engage in any activity that requires you to stay conscious and awake.

Before you take this drug

It is not recommended to use endometrin in the event that you've had reactions to the hormone progesterone or if you suffer from

  • A history of stroke, clots, or circulation issues;
  • Cancer of the uterus or breast;
  • Abnormal vaginal bleeding
  • Liver disease
  • If you've recently experienced tubal pregnancy, an unfinished abortion, or a "missed" abortion,

To ensure that endometrin is suitable for you, inform your doctor if you suffer from:

  • High blood pressure and heart diseases congestive heart failure
  • Migraines,
  • Asthma;
  • Kidney disease;
  • Seizures or epilepsy;
  • An underlying depression history;
  • Risk factors that could lead to coronary artery disease (such as factors that increase the risk of coronary artery disease (such as diabetes, lupus cholesterol, and relatives with a history of coronary diseases, smoking cigarettes, and being obese).

Utilizing endometrin could increase the risk of stroke, blood clots, or heart attack, as well as breast cancer. Consult your physician regarding this possibility.Do not take Endometrin when you are expecting, unless you are taking this medication in conjunction with fertility therapy.Speak to your doctor if you develop a pregnancy while you are receiving treatment.Endometrin may be present in breast milk and cause harm to nursing babies.

How to take Endometrin?

Make sure you use Endometrin according to the prescription given to you. Follow the directions on the prescription label. Don't use this medication in greater or lesser quantities or for longer periods than the recommended time.Do not take it by mouth. The use of endometrin is only in the vagina.Inject this medication straight into your vagina using the applicator that is provided. Utilize a disposable applicator once, and then throw it to the side.Check all information about your patient, such as medication guides and instructions sheets that you receive. Talk to your pharmacist or doctor if you have any concerns.Make sure to take this medicine before going to bed in the event that it causes dizziness or somnolence.The dosage of endometrin is a hundred mg injection into the vagina 2 or 3 times per day, beginning following egg (oocyte) retrieval. This can continue for a maximum of 10 weeks.The effectiveness of the drug in women aged 35 and older hasn't been confirmed. The dosage of endometrin that is appropriate for this age range isn't known.

Regularly conduct physical examinations and examine any lumps in your breasts every month when you are using progesterone vaginally.If you require medical or surgical tests or are in bed, it is possible to stop taking this medication for a brief period of time. Any surgeon or doctor who treats you should be aware that you're taking endometrin.It is normal for women to experience vaginal discharge that lasts for several days following the use of this medication. Discuss this with your doctor if you are concerned about the discharge from your vagina.Keep the endometrin inserts at room temperature, away from heat, humidity, and light.

What happens if I miss the dose?

Take the missed dose when you remember. Do not take your missed dose if you are nearing the time for the next dose.Don't use any extra medication to replace the missed dose.Consult your physician if you have missed multiple doses.

What happens if I overdose?

An overdose of the drug is not likely to be a danger. You should seek medical attention in an emergency or contact the Poison Helpline at 1-800-222-1222 in the event that anyone has swallowed the drug accidentally.

What should be avoided?

Do not take another vaginal product within 6 hours prior to or following the use of endometrin. Only use vaginal products your doctor has suggested.Beware of vaginal yeast treatments unless your doctor advises you to.Endometrin can impair your thinking or reactions. Be cautious when you drive or perform things that require you to be aware.

Interaction with other drug

Other medications can interfere with progesterone vaginal, such as prescription and over-the-counter supplements, vitamins, and herbal products. Inform all of your health professionals about any medications you take in the present and about any medication you stop or start taking.