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Sumatriptan and naproxen

Generic name: Naproxen and sumatriptan [ na-PROX-en-and-SOO-ma-TRIP-tan ]
Brand name: Treximet
Dosage format: Oral tablet (500 mg–85 mg)
Drug class: Antimigraine agents

What are Naproxen and sumatriptan?

Naproxen is a nonsteroidal anti-inflammatory medication (NSAID). Sumatriptan is a migraine headache medication. Naproxen and sumatriptan are combination medicines that are used for migraine headaches. Naproxen and sumatriptan will only treat headaches that have already begun. headache that has already started. It cannot prevent headaches or decrease the frequency of attacks.

Naproxen and sumatriptan should never be prescribed for treating cluster headaches or any other headache that causes a loss of motion on the opposite side of your body. Naproxen and sumatriptan can also be used for reasons not covered in this guide.

Adverse effects of Naproxen and sumatriptan

Seek medical attention immediately. If you notice symptoms of an allergic reaction (hives, breathing problems, or swelling of your throat or face) or an extreme skin reaction (fever, sore throat, burning eyes, skin irritation, or a red or purple rash on your skin that is peeling and blistering),

Stop taking naproxen and sumatriptan and seek medical attention when you experience an adverse reaction to a drug that affects many areas of your body. Symptoms may include skin inflammation, fever, swollen glands, muscle aches and weakness, extreme bleeding, or yellowing of the eyes or skin.

Stop taking this medication and seek immediate medical assistance. If you are experiencing indications of stroke or heart attack: chest pain spreading to your shoulder or jaw, suddenly feeling numb or weak in one part of your body or in your speech, and feeling tired,

This medicine can cause serious adverse effects. Stop taking this medicine and contact your doctor immediately in the event of:

  • Numbness, tingling, or blue-colored appearance of your toes or fingers;
  • Leg cramps, burning, coldness, or a heavy sensation in your legs or feet;
  • Severe headache with blurred vision and pounding sensations in your neck or ear;
  • A seizure;
  • Heart issues: swelling, weight gain, rapid feeling tired;
  • Serotonin levels are high in the body, causing hallucinations, agitation, and sweating. rapid heart rate, shivering muscles stiffness, twitching loss of coordination nausea vomiting, diarrhea
  • Kidney problems: little or no urinary frequency; swelling in your ankles or feet; feeling exhausted or breathless.
  • Problems with the liver: loss of appetite, stomach pain (upper right side), fatigue, itching, dark urine, stools with a clay-colored color, jaundice (yellowing of the eyes or skin);
  • Low red blood cells (anemia)—pale skin, uncharacteristically tired, feeling lightheaded or breathless;
  • Signs of stomach bleeding—bloody or black stools and coughing up blood; or vomit that resembles coffee grounds or
  • Stomach issues—sudden stomach pain (especially after eating) vomiting, constipation, bloody diarrhea, and weight loss.

Common adverse effects of sumatriptan and naproxen could include:

  • Dizziness, drowsiness, feeling tired or weak;
  • Irregular heartbeats;
  • Tingling or numbness in your toes and fingers;
  • Dry mouth, heartburn, nausea
  • Sensation of hot sensation hot
  • Tight muscles, tension, or pressure in your throat or chest.

This is not an all-inclusive list of possible side effects, and other side effects could occur. Consult your physician for advice on medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


You should not use sumatriptan and naproxen if you have heart problems, uncontrolled high blood pressure, blood circulation problems, Wolff-Parkinson-White syndrome, a history of heart attack or stroke, severe liver disease, a history of severe allergic reactions to aspirin or an NSAID, or if you are in late pregnancy.

Naproxen may increase your chance of having a fatal stroke or heart attack. Avoid using this medication prior to or following heart bypass surgery (coronary bypass graft for the artery, or CABG). Naproxen can also cause bleeding in the stomach or the intestinal tract and can cause fatal bleeding.

Seek medical attention immediately. If you are experiencing indications of an attack on your heart or stroke: chest pain spreading to your shoulder or jaw, suddenly feeling numb or weak on the opposite side of your body, in your speech, or feeling sluggish,

Don't take naproxen or sumatriptan within the first 24 hours of or after taking a different migraine medication.

Before you take this drug

You should not take this medicine if you're sensitive to naproxen (Aleve, Anaprox, Naprosyn) or sumatriptan (Imitrex) or if you suffer from:

  • Heart problems, uncontrolled blood pressure,
  • A history of stroke or heart attack (including TIA or "mini-stroke");
  • Wolff-Parkinson-White Syndrome (sudden fast heartbeats) or other heart rhythm disorder
  • Blood circulation issues (including problems with the circulation of blood to your legs and arms, stomach, intestines, or kidneys);
  • A background of asthma or a severe allergic reaction following the use of aspirin or an NSAID
  • Severe liver disease that is severe

Naproxen can increase the chance of having a fatal stroke or heart attack even in the absence of risk factors. Do not take this medicine prior to or following the procedure for heart bypass (coronary bypass grafts for artery bypass, or CABG). Naproxen can also cause diarrhea or stomach bleeding, which could be fatal. These conditions can happen without warning when you are taking naproxen or sumatriptan, particularly in older individuals. Do not take naproxen or sumatriptan if you've used an MAO inhibitor in the last 14 days. A risky drug interaction may occur. MAO inhibitors comprise isocarboxazid, linezolid, Methylene Blue injection, rasagiline, phenelzine, and tranylcypromine, among others. Do not consume sumatriptan and naproxen within 24 hours prior to or after taking another migraine headache medication, such as:

  • Sumatriptan tablets, injections, or nasal spray;
  • Almotriptan, eletriptan, and frovatriptan; naratriptan, rizatriptan, or zolmitriptan; or
  • Ergot medicine such as ergotamine, dihydroergotamine, or methylergonovine.

Inform your doctor if you have ever experienced:

  • Heart issues or stroke (in you or a family member);
  • High blood pressure, high cholesterol, diabetes, or smoking;
  • Asthma;
  • Epilepsy or any other seizure disorder or
  • Kidney or liver disease

If you're expecting and you are taking naproxen unless your doctor advises you to, Taking an NSAID in the final 20 weeks of your pregnancy could cause serious kidney or heart issues in the unborn baby and may cause complications during your pregnancy. It is not recommended to breastfeed while you are taking this medication. Naproxen and sumatriptan aren't permitted for use by individuals less than 12 years old.

How to take sumatriptan and naproxen?

Follow all the instructions on the prescription label, and be sure to read all prescription instructions. Make sure you are using the lowest dose that works for treating your problem. In excess, using migraine headache medication could cause your headaches to get worse. Take one tablet when you begin to feel headache-like symptoms or after an attack has started. It is possible to take the medication either with or without food. Take the tablet in one swallow and don't crush, chew, or break it. If your headache doesn't disappear, contact your doctor before taking another tablet. If your headache doesn't completely disappear or disappears but returns, then take a second tablet two hours after the first.

If you are between 12 and 17 years old, do not take an additional tablet without consulting your physician. You must wait at least two hours before taking another tablet. Don't take more than two tablets within 24 hours. If your symptoms haven't improved, consult your doctor before taking additional tablets. It is not recommended to use sumatriptan or naproxen for more than 5 headaches within 30 days (or more than 2 headaches in a period of 30 days if you're aged between 12 and 17 years old). Keep at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose for Migraine:

Initial dose: 1 tablet (sumatriptan-naproxen 85/500 mg) orally once
Maximum dose: 2 tablets (sumatriptan-naproxen 85/500 mg) in a 24-hour period, taken at least 2 hours apart.

Use only when a clear diagnosis of migraine is made. If migraine is not responding to treatment, reevaluate the migraine diagnosis prior to treating any further attacks.
The security of treatment for more than five migraine headaches (on average) over a period of 30 days is not yet established.
This drug is not used to treat migraine attacks.

Use: As an urgent treatment of migraine that includes or without an aura.

Usual Pediatric Dose for Migraine:

Age 12 years old or older
Initial dose: 1 tablet (sumatriptan-naproxen 10/60 mg) orally once
Maximum dose: 1 tablet (sumatriptan-naproxen 85/500 mg) in a 24-hour period.

Use only when a clear diagnosis of migraine is made; if migraine doesn't respond to treatment, consider rethinking the migraine diagnosis prior to treating any further attacks.
The risk of treating more than two migraine headaches (on average) within a 30-day time frame has not been proven.
This medication is not recommended to prevent migraine attacks.

Use: As an immediate treatment of migraine that is with or without aura for patients who are 12 years of age or more.

What happens If I miss a dose?

Since naproxen and sumatriptan are only taken when required, they don't have a regular dosing schedule. Do not take more than two tablets within 24 hours.

What happens if I overdose?

Get medical attention immediately or contact the poison help line at 1-800-222-1222.

What should be avoided?

Beware of drinking alcohol. It can increase the chance of stomach bleeding. Do not take aspirin or other salicylates like Nuprin Backache Caplet Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and many others. Avoid driving or engaging in hazardous activities until you are aware of how naproxen and sumatriptan affect you. Your reactions may be impaired. Consult a physician or pharmacist prior to using any other medications for swelling, fever, pain, or cold or flu symptoms. They could contain ingredients similar to naproxen (such as aspirin, ibuprofen, or ketoprofen).

Interaction with other drugs

Consult your physician before using naproxen or sumatriptan when you are taking an antidepressant. Taking certain antidepressants along with an NSAID can cause bleeding or bruises easily.

Inform your doctor about all other medications you take, particularly:

  • Cyclosporine, lithium, and methotrexate;
  • Blood pressure or heart medication, including diuretics or "water pills";
  • A blood thinner—warfarin, Coumadin, Jantoven; or
  • Steroid medicine—prednisone, dexamethasone, and others.

This list isn't exhaustive. Other drugs can interact with naproxen or sumatriptan. This includes prescription and over-the-counter medications, vitamins, and herbal products. Not all possible interactions are listed here.