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Excedrin Sinus Headache Caplet

Generic name: acetaminophen and phenylephrine [a-SEET-a-MIN-oh-fen-and-FEN-il-EFF-rin]

Brand names: Acetaminophen Congestion and Pain, Alka-Seltzer Plus Cold and Sinus, Excedrin Sinus Headache, Mygrex, Sudafed PE Pressure Plus Pain,… Show all 20 brands
Drug Class: Upper Respiratory Combinations

What is Excedrin Sinus Headache Caplet?

Acetaminophen can help relieve pain and decrease fever.Phenylephrine shrinks the blood vessels of the nasal passages. Nasal congestion may be caused by dilatation of blood vessels.Excedrin Caplet Sinus Headache is used to treat headaches and other symptoms such as fever, body pains, sinus congestion, or a stuffy nose caused by allergies. It can also be used for colds.Excedrin Sinus Headache The caplet can be used in other ways not mentioned in this medication guide.

Side effects of Excedrin Sinus Headache Caplet

Symptoms of an allergic reaction may include: hives, difficulty breathing, swelling of lips, face, tongue or throat and difficulty swallowing. Seek medical assistance immediately if these occur.Acetaminophen can lead to serious skin reactions that may prove fatal, even if taken before without adverse events. Call your doctor immediately if you experience skin redness, blistering, or peeling.

The medicine can cause serious side effects. If you experience:

  • Heart rate can be fast, slow, or uneven.
  • Confusion, hallucinations;
  • Tremor, seizure (convulsions);
  • Little or no urinating is acceptable.
  • Nausea; upper stomach pain; itching; loss of appetite; and dark urine or clay-colored stools. Jaundice.
  • Symptoms of dangerously high blood pressure include a severe headache, blurred or buzzing vision, anxiety, confusion, chest discomfort, shortness of breath, and seizures.

Side effects of Excedrin Sinus Headache Caplet include:

  • Dizziness, weakness;
  • Mild headache
  • Mild nausea, diarrhea, upset stomach;
  • Runny nose
  • Feeling nervous, restless, or anxious
  • Sleep problems (insomnia).

There may be other side effects.For medical advice regarding potential side effects, always contact your physician first. For reporting side effects directly, the FDA can be reached at 1-800-FDA-1088.


You should not take this medication if you've taken a MAO inhibitor within the last 14 days. A dangerous drug interaction may occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (rasagiline), selegiline (tranylcypromine), and rasagiline.Don't take more than recommended. An acetaminophen overdose can cause liver damage or death.Acetaminophen can cause severe skin reactions in rare cases. If you notice skin redness, a rash, blistering, or peeling, stop taking the medicine immediately and contact your doctor.

Before you take this drug

If you have an allergy to acetaminophen or phenylephrine (Tylenol), then do not use Excedrin Sinus Headache Caplet.If you have taken a MAO inhibitor within the last 14 days, do not take this medication. It is possible that a dangerous drug interaction will occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine), rasagiline (selegiline), and tranylcypromine.If you have any other medical conditions or concerns, ask your doctor or pharmacist whether it's safe to take the medicine.

  • Liver diseases; cirrhosis; a history of alcoholism; or if you consume more than three alcoholic drinks per day.
  • Coronary heart disease and high blood pressure.
  • Overactive thyroid
  • Pheochromocytoma
  • If you are taking an antidepressant,

Excedrin Sinus Headache Caplet is not known to harm a developing baby. If you are pregnant, do not take cough and cold medicines without consulting your doctor.Acetaminophen, phenylephrine, and other drugs can pass through breast milk. This may cause harm to a nursing infant. Decongestants can also reduce breast milk production. If you are pregnant, do not take cough and cold medicines without consulting your doctor.Do not give children under the age of five any cough or cold medicine.

How to take Excedrin Sinus Headache Caplet?

Do not exceed the recommended dosage. Use only as directed. Cold medicines are usually only taken for a few days until symptoms disappear.Don't take more than recommended.Acetaminophen overdose can result in liver damage or even fatality.One packet of powder should be dissolved in 4 ounces or more of water. Mix this mixture well and consume it immediately.Drop the effervescent tablet into a glass full of water (at least 4 ounces or half a cup). This mixture should be stirred and consumed immediately.If you continue to have symptoms after three days, you should call your doctor. This is especially true if the fever persists, if there are any persistent headaches, if the skin rash appears, if there is redness or swelling, or if it gets worse.Tell your doctor or surgeon, if you've taken this medication within the last few days, if you are going to need medical testing or surgery.Store away from heat and moisture at room temperature.

What happens if I miss the dose?

You may not have a schedule for taking Excedrin Sinus Headache Caplet. Take the missed dose immediately if you take the medication regularly. If your next scheduled dosage is near, skip the missed dose. You should not take more medicine to compensate for a missed dose.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Acetaminophen overdoses can be deadly.Loss of appetite, nausea and vomiting, sweating, and confusion or weakness are the first signs. Other symptoms include dark urine and yellowing skin or whites of the eyes.

What should be avoided?

This medication can affect your ability to think or react. You should be careful when driving or doing anything else that requires alertness.Before using any other pain reliever, allergy medicine, or sleep medicine, consult your doctor or pharmacist. Many combination medications contain acetaminophen, also known as APAP. Taking some products together may cause an overdose of acetaminophen, which could be fatal.Avoid alcohol. Acetaminophen can increase the risk of liver damage.

Interaction with other drug

Other drugs, such as vitamins and herbal products, may also interact with acetaminophen or phenylephrine. Inform your healthcare providers of all the medicines you are taking and those you plan to take.