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Zejula

Generic Name: Niraparib [nye-RAP-a-rib]
Drug Class: PARP inhibitors

What is Zejula?

Zejula is a "maintenance" treatment for adults to prevent certain kinds of cancer from returning. This includes cancers of the ovary (female reproductive organs that produce eggs), the peritoneum (where eggs are created), the fallopian tube (tube that carries eggs that are released by the ovaries towards the uterus), and the peritoneum (the skin that runs along the abdomen's inside and covers a number of internal organs).

Zejula is administered after receiving chemotherapy (with oxaliplatin or cisplatin as well as carboplatin or other similar drugs) that has cured your tumor. the medication.Zejula is often used in cases where the cancer has particular gene markers (an anomalous "BRCA" gene) or other mutations in genes. Your physician will ensure that you have the right type of tumor to be treated with Niraparib.

Zejula belongs to a category of drugs known as poly (ADP-ribose) polymerase (PARP) inhibitors. Niraparib is a drug that blocks the development and spread of cancerous cells within the body.

Side effects of Zejula

See a doctor immediately. If you exhibit indications for an allergy reaction with Zejula, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue,

Take a break from this medication and contact your doctor immediately if you notice indications of a bone-marrow disease: fever, frequent infections, fatigue, weakness, feeling tired, weight loss, pus in your urine, bleeding from your stool, easy bruising, or bleeding.

Zejula could cause severe adverse effects. Consult your physician right away in the event that you experience:

  • Heartbeats that are pounding or racing within your chest
  • White patches or sores in the mouth or in your gums; problems speaking or swallowing; dry mouth; bad breath; a change in perception of taste
  • Discomfort or burning sensation during urination;
  • Headache Vision changes, confusion, or seizures without pounding your neck or ear.

The treatment for cancer may be delayed or discontinued permanently when you experience certain negative side effects.

Common Zejula side effects can include:

  • Stomach discomfort, loss of appetite, nausea, and vomiting;
  • Constipation, diarrhea;
  • Unusual blood test results;
  • Minimal or no urination changing the hue of urine; pain in urine;
  • Back or muscle discomfort;
  • Headache, dizziness;
  • Sleep problems (insomnia);
  • Tiredness;
  • Cough, breath shortness,

It's not a comprehensive listing of all possible adverse consequences, but other consequences could also occur. Consult your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Before you take this drug

To make sure that Zejula is safe for you, inform your doctor if you've ever experienced:

  • An allergy or sensitivities to aspirin or tartrazine (food coloring);
  • Heart disease;
  • High blood pressure
  • Liver disease.

It is possible that you will need to take a pregnancy test that is negative prior to commencing treatment with Niraparib.

Niraparib can harm a newborn baby. Don't use it if you are expecting. Make sure you use effective birth control when you are using the drug and for a minimum of 6 months following the last dose. Inform your doctor when you are pregnant.It could be more difficult for you to become pregnant if you're taking this medication.Don't breastfeed during the course of this medicine for at least one month following the last dose.

How to take Zejula?

You should take Zejula as directed by your physician. Follow all instructions on your prescription label, and review all medication guides and instructions on the label.Zejula can be taken in combination with or without food; however, it must be taken in the exact same way every day.Use this medicine before bed if it causes stomach upset.

Take the capsule or tablet in its entirety and don't crush, chew, break, or break it open.If you vomit immediately after taking Zejula, don't take a second dose. The next dose should be taken as per the schedule.You might require regular medical examinations, and the treatment for cancer could be delayed based on the results.Your heart rate and blood pressure should be monitored regularly.Keep this medicine in its original bottle at room temperature, away from heat and moisture.

Details on dosage

Usual Adult Dose for Ovarian Cancer:

300 mg orally, once a day, until the disease progresses or becomes unacceptably toxic.

Usual Adult Dose for Fallopian Tube Cancer:

300 mg orally, once a day, up to the point of unacceptably toxic

Usual Adult Dose for Peritoneal Cancer:

300 mg orally, once a day, until the disease progresses or becomes unacceptably toxic.
Comments:
Start treatment with this medication no later than 8 weeks following a patient's most recent platinum-containing treatment.
Uses:
For maintenance therapy for epithelial ovarian, recurrent fallopian tube, and primary peritoneal tumors that are experiencing either a complete or partial reaction to chemotherapy based on platinum
Treatment of adult patients with advanced ovarian, fallopian tube, or primary peritoneal tumors who have had treatment with three or more chemotherapy regimens and patients whose cancer is linked to homologous-recombination deficiency (HRD) positive status, which is defined by one of the following:
a deleterious or suspected deleterious BRCA mutation
OR
genomic instability, and who have advanced for more than 6 months following the chemotherapy with platinum.

What happens If I miss a dose?

Don't miss the dose you missed, and take your next dose at the normal time. Do not take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.

Warnings

Take a break from Zejula and consult your physician immediately if you notice frequent infections, fever weakening, fatigue, or shortness of breath. the loss of weight and urine with blood or stools, or easy bleeding or bruising. These could be signs of bone marrow disease and can lead to the death of a patient.

It is not recommended to take Zejula during pregnancy. Avoid pregnancy for at least six months after the last time you used this medication.It is not recommended to breastfeed during treatment with Zejula or for a minimum of one month following your last dose.

Interaction with other drugs

Other medications may be incompatible with Zejula, such as prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your doctor all other medicines you take.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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