What is Doravirine lamivudine and tenofovir?
Doravirine and lamivudine are antiviral medications that stop the human HIV (immunodeficiency) virus from multiplying within your body. Doravirine, Lamivudine, and Tenofovir are a combination of medicines used to treat HIV. This is the virus that can cause acquired immune deficiency syndrome. Doravirine, lamivudine, and tenofovir are not cures for HIV or AIDS. This medication guide does not list all possible uses for lamivudine and tenofovir.
Side effects of Doravirine lamivudine and tenofovir
If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of the face, lips, or throat.
Doravirine, tenofovir, and lamivudine can cause serious side effects. If you experience:
- Urinating more or less frequently than usual
- Increased thirst
- New or worsening pain in the bones
- Muscle pain or weakness;
- You may experience pain in your hands, feet, arms, or legs.
Doravirine affects the immune system. This can cause side effects, even weeks or months after taking this medication. You should tell your doctor if:
- Signs of an infection: fever, sweating at night, swollen lymph glands, coldsores, coughing, wheezing, and diarrhea.
- Problems with balance, eye movements, or speech, or even a prickly sensation;
- Impotence, menstrual irregularities, and swelling of the neck or throat
Some of the common side effects associated with doravirine (also known as lamivudine) and tenofovir include:
- Nausea;
- Dizziness;
- Strange dreams.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Similar/related drugs
Biktarvy, Descovy, Truvada, Tenofovir, Atripla, Complera, and Epzicom
Warnings
Inform your doctor of all the medications you are taking, as well as any new ones. Some drugs are not to be taken together, and others can cause drug interactions. You may experience a reactivation or worsening of your hepatitis B after stopping doravirine, lamivudine, and tenofovir. You may require frequent liver function testing for several months.
Before you take this drug
This medicine should not be used if you have an allergy to lamivudine or tenofovir. Several drugs can cause harmful interactions. Certain drugs shouldn't be taken with lamivudine, tenofovir, or doravirine. If you've taken any of these medicines within the last 4 weeks, your doctor may alter your treatment plan.
- Enzalutamide;
- Mitotane;
- Rifampin;
- Rifapentine;
- John's wort;
- Seizure medicine—carbamazepine, phenobarbital, phenytoin, or oxcarbazepine.
Tell your doctor about any of the following:
- Hepatitis b;
- Kidney disease
- Bone problems (including a broken bone or osteoporosis).
Doravirine and lamivudine may increase your risk of breaking a bone. Speak to your doctor about how you can keep your bones strong.
Use your medication properly to control infections. HIV can be transmitted to your child if you do not control the virus during pregnancy. You may have your name listed in a registry that tracks the effects of antiviral medicines on the baby. Breast-feeding is not recommended for women with HIV/AIDS. Even if the baby was born HIV-free, the virus can be transmitted to the infant through your breast milk. The use of this medicine by those under 18 is not recommended.
How to take Doravirine lamivudine and tenofovir?
Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label. Take your medicine every day at the same time, with or without eating. You may also need to take a dose of Pifeltro (doravirine) 12 hours after taking the combination of lamivudine and tenofovir (Delstrigo). Do not forget to follow your doctor's instructions. Read all the instructions and medication guides that you receive. Do not alter your dosage or schedule without consulting your doctor. Each person living with HIV should be under the care and supervision of a physician. You may need to undergo blood and urine tests. This is to ensure that you are not suffering from any conditions that would make it unsafe for you to use doravirine (lamivudine) and tenofovir. You may need to have your bone mineral density tested. Store the tablets away from heat and moisture at room temperature. Keep tablets in their original containers, with packets or canisters of moisture-absorbing preserver. Do not place the tablets in a daily pillbox. This medicine may make the hepatitis B virus active or worsen in the months following your last dose. You may require frequent liver function testing while taking this medication and for several weeks after you stop using it.
Details on dosage
Adult dose for HIV infection:
Take 1 tablet once daily, orally.
Use: As a complete regimen for the treatment of HIV-1 infection in patients with no prior antiretroviral treatment history or to replace the current antiretroviral regimen in patients virologically suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to the components of this drug.
What happens if I miss the dose?
If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once. Refill your prescription before you run out. If you skip doses, your virus may become resistant to the medication.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.
Interaction with other drug
The kidneys can be damaged by lamivudine and doravirine. This is especially true if you are also taking certain medications for cancer, arthritis, cancer, transplant failure, bowel disorders, high blood pressure, or pain (including Advil and Motrin).
Tell your doctor all of your other medications, including:
- If you've taken rifabutin in the last 4 weeks, or if it was prescribed to you before that time,
This list is incomplete. Doravirine and lamivudine may be affected by other drugs, including vitamins, herbal products, prescription medicines, and over-the-counter medicines. This list does not include all possible drug interactions.
