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Carbidopa and levodopa enteral 

Generic name: carbidopa and levodopa enteral (Duopa) [KAR-bi-doe-pa-and-LEE-voe-doe-pa]
Duopa
Dosage form: enteral suspension (4.63 mg–20 mg/ml)
Drug class: dopaminergic agents

What is Carbidopa and levodopa enteral?

Carbidopa, or Levodopa Enteral (Duopa), is a combination of medicines used to treat advanced Parkinson’s disease. This medication guide does not list all possible uses of levodopa or carbidopa.

Side effects of Carbidopa and levodopa enteral

If you experience any of the following signs and symptoms of an allergic reaction: difficulty breathing, hives or swelling to face lips throat

Carbidopa and levodopa taken via enteral administration may lead to serious side effects, including death. If you experience:

  • Nausea, vomiting, stomach pain, fever
  • Constipation that is ongoing, bloody, or tarry;
  • Difficulty breathing;
  • Pain, swelling, redness, or warmth around the tube inside your stomach wall
  • Uncontrolled facial movements (such as lip smacking and frowning; tongue movement or blinking)
  • A feeling of lightheadedness, as if you could pass out.
  • Fast or irregular heartbeats can cause chest pain.
  • If you are suddenly sleepy after being alert or have daytime sleepiness,
  • You may experience numbness in your fingers or toes.
  • Hallucinations, depressive thoughts, or suicidal ideas

Duopa can cause some people to fall asleep while doing normal activities during the day, such as driving, working, talking, or eating. Inform your doctor of any daytime sleepiness problems or drowsiness. Your sexual or gambling urges might be strong. If this happens, talk to your doctor.

Side effects of levodopa or carbidopa may include:

  • Increased blood pressure
  • Swelling in your lower legs;
  • Nausea;
  • Depression
  • Mouth or throat pain

There may be other side effects. Call your physician if experiencing side effects; otherwise contact the FDA at 1-800-FDA-1088 to report it.

Similar/related drugs

Ropinirole, pramipexole, benztropine, carbidopa/levodopa , Sinemet, Exelon, and Gocovr

Warnings

This medication can cause serious side effects. Contact your doctor immediately if you experience stomach pain, nausea, constipation that continues, fever, bloody stools or tarry stool, or any problems with the tube used to administer this medicine (redness or warmth, swelling, or oozing).

Before you take this drug

You should avoid taking this medication if you have recently consumed an MAO inhibitor within 14 days. A dangerous drug interaction may occur. MAO inhibitors are isocarboxazid (linezolid), methylene blue injection, phenelzine, and tranylcypromine.

Inform your physician of any of the following conditions:

  • A stomach surgery or an ulcer is available.
  • Fainting or low blood pressure;
  • Heart disease or high pressure.
  • Problems falling asleep during the day.
  • Problems with muscle movement
  • Depression or mental illness
  • Glaucoma;
  • Nerve problems can cause numbness in the hands or feet.

The risk of cancerous skin is higher in people with Parkinson's (melanoma). Consult your doctor for information on skin symptoms.

This medicine is not known to harm an unborn child. Inform your physician immediately if you are pregnant or planning on becoming pregnant. Duopa may slow down the production of breast milk. Inform your doctor if breastfeeding is a concern. No one under the age of 18 is allowed to use this product.

How to take Carbidopa and levodopa enteral?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed.

The tube is inserted through an incision made in the stomach wall. This tube is connected to an infusion unit. You will be shown how to operate the pump by a healthcare professional. Please read and follow all instructions for use that come with your medication. If you don't understand the instructions, ask your doctor or pharmacist.

Duopa is packaged in a plastic cassette that can be attached to an infusion pump. Each cassette should only be used once and then thrown out.

Duopa infusions are usually spread over a period of 16 hours. You should not stop taking this medication or alter your dosage without consulting your doctor. If your infusion pump has been disconnected for more than 2 hours, you may have to take the pill form of levodopa or carbidopa.

Duopa can interfere with certain medical tests. Duopa can affect the results of certain medical tests. Do not freeze cassettes. Store them in their original packaging in the fridge. Infuse Duopa from a cold cassette. Infuse Duopa using a cassette that is cold.

What happens if I miss the dose?

If you have missed a dose, extra medicine may be needed. Refill your prescription before you run out.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Do not drive or engage in hazardous activities until you have determined how the medicine will affect you. You may have impaired reactions. You may feel dizzy if you get up quickly from a seated or lying position.

Avoid eating foods high in iron and protein. This can make it more difficult for your body's digestion and absorption of levodopa and carbidopa. Speak to your doctor or dietitian for advice on what foods you should eat and avoid. Alcohol consumption can have side effects when taken with this medication.

Interaction with other drug

Duopa can make you more drowsy if taken with other drugs. Before taking an opioid, sleeping pill, muscle relaxer, or medicine to treat anxiety or seizures, consult your doctor.

Tell your doctor all of your other medications, including:

  • Metoclopramide;
  • Mineral or vitamin supplements containing iron
  • Blood pressure medicine;
  • Medicine to treat mental illnesses such as schizophrenia.

This list is incomplete. Duopa may be affected by other drugs, such as prescription and over-the-counter medicines and vitamin and herb products. This list does not include all possible drug interactions.

 

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