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Zavegepant nasal

Generic Name: Zavegepant nasal
Brand Name: Zapret
Dosage Form: Nasal spray (10 mg)
Drug Class: CGRP inhibitors

What is Zavegepant?

Zavegepant Nasal (for application in the nasal passages) is used by adult patients to manage migraines that have or do not have an aura.Zavegepant nasal drops will not help prevent migraines.Zavegepant nasal can be used for other purposes not covered in this medication guide.

Side effects of Zavegepant

See a doctor immediately. If you notice symptoms that indicate an allergy that include hives, trouble breathing, and swelling of your lips, face, and tongue,

Common adverse effects of zavegepant nasal could include:

  • Changes in your sense of taste
  • Nausea, vomiting,
  • Nasal discomfort.

This is not a comprehensive list of possible side effects, and other side effects could be present. Consult your physician for medical advice regarding the consequences. You can report any symptoms to the FDA at 1-800-FDA-1088.


Only use according to the directions. Inform your doctor if you are taking other medications or have any medical conditions or allergies.

Before you take this drug

Do not take the nasal spray zavegepant if you are allergic.

Speak to your doctor if you are or have ever been diagnosed with:

  • Kidney or liver disease

Talk to your doctor if are pregnant or nursing.

How to take Zavegepant nasal?

Follow all instructions on the prescription label and read the medication guide or instructions sheets. Follow the medication precisely as directed.Do not consume zavegepant by mouth. It is only for use inside devices for nasal breathing supplied with Zavegepant nasal.

Zavegepant nasals are usually administered in a single spray to only one nostril. Don't try to prime, test, or press the plunger on the device prior to use.

Do not apply this medication to each nostril.

To apply the spray for nasal use:

  • Breathe through your nose slowly. While your head is upright, insert the tip of the bottle into one nostril, then press the other nostril to close. Breathe into your nostrils and spray the medication through your nose.
  • When the solution gets into your mouth, eyes, or even on your face, wash with water.
  • Don't use your nasal blower for more than a couple of minutes. Do not exceed one spray (10 mg) of zavegepant in the first 24 hours or eight sprays in 30 days.

Each nasal spray is intended for one-time use (in only one nostril). Dispose of the nasal spray after a single use or when the medicine has expired.

The nasal spray you do not use should be stored in the original packaging at room temperature, away from heat and moisture. Don't freeze it.

Details on dosage

Usual Adult Dose for Migraine:

For the treatment of migraine that is acute Spray for nasal use: 10 mg as a single spray to one nostril as needed
Maximum dose: 10 mg (one spray) in a 24-hour period.
The risk of treating more than eight migraines over a period of 30 days isn't known.
Use: To treat the acute treatment of migraine that includes or without aura in adults.

What happens If I miss a dose?

Zavegepant nasal spray is prescribed for emergencies and does not require an everyday dose. Contact your physician if you feel the medication isn't working.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Do not take other medicines for your nose unless your doctor advises you to.

Interaction with other drugs

Do not use a nasal decongestant in the first hour following the use of the nasal zavegepant.

Other drugs can interact with Zavegepant's effects, such as prescription and over-the-counter medications, vitamins, and herbal products. Discuss with your doctor all other medications you take.



Prescription only

Pregnancy & Lactation

CSA Schedule*

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