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Articaine and Epinephrine

Generic name: articaine and epinephrine [AR-ti-kane-and-EP-i-NEF-rin]
Brand name: Septocaine
Dosage form: injectable solution (4%-1:100000; 4%-1:200,000)
Drug class: local injectable anaesthetics

What is Articaine and Epinephrine?

Articaine and epinephrine are both anaesthetics (numbing medications). They block signals to your brain that are sent out by nerves in your body.Epinephrine and articaine are a combination medication used to reduce the pain in your mouth during a tooth procedure.Epinephrine and articaine can also be used for reasons not mentioned in this medication guide.

Side effects of Articaine and Epinephrine

See a doctor immediately. If you experience any of the following symptoms, they are warning signs of an allergic reaction: difficulty breathing and swelling or puffiness of your lips, face, or tongue.

Inform your carers immediately in the event that you are suffering from:

  • Breathing that is shallow or weak;
  • A low heart rate;
  • A feeling of lightheadedness, as if you've passed out;
  • Blurred vision, or ringing in your ears;
  • Anxiety, confusion, unrestful sensations, or shakes.

Consult your dentist or doctor immediately if there is any pain, swelling, or bleeding that is heavy following the procedure.

Common adverse effects of articaine and epinephrine can include:

  • Tongue pain or swelling; gum swelling or redness;
  • A small amount of swelling on your face.
  • Headache
  • Tingling and numbness

This is not a comprehensive list of possible side effects, and others could happen. Consult your physician to seek medical advice on adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


It is not recommended to take the drugs epinephrine and articaine if you have ever experienced the reaction of an allergy to any form of numbing drug.

Before you take this drug

You shouldn't take Epinephrine and Articaine if you are averse to any form of numbing medication.

To ensure that articaine and epinephrine aren't harmful to you, inform your doctor when you are suffering from:

  • A heart rhythm disorder
  • Blood pressure, and hypertension;
  • Asthma, an sulphur allergy,
  • A background of seizures

FDA classification for pregnancy C It is unclear whether epinephrine or articaine will cause harm to a baby who is not yet born. Inform your doctor if you are expecting or planning to get pregnant while taking this medication.It's not clear if the epinephrine and articaine are absorbed into breast milk or whether they can harm the baby who is nursing. Inform your physician immediately if you plan on breastfeeding your infant.

How to take Articaine and Epinephrine?

Epinephrine and articaine are given as injections, generally injected into the gums of the mouth. This injection will be administered at a dental office or in an oral surgical setting.

What happens if I miss the dose?

Since epinephrine and articaine are administered prior to the procedure, you're not likely to be following the dosing schedule.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Help Line at 1-800-222-1222.Overdose symptoms can include severe sleepiness, fainting seizures (convulsions), rapid breathing, or an elongated heart.

What should be avoided?

The medication may cause numbness that lasts for a prolonged period of time. Beware of eating food, chewing gum, or drinking hot beverages until the sensation in your mouth has completely returned. Chewing when your mouth is numb can cause a bite injury to your tongue, lips, or the inside of your cheek.

Interaction with other drug

Discuss with your doctor any medications you are taking and the ones you begin or stop taking when you are treated with epinephrine and articaine, particularly:

  • An antidepressant—amitriptylline, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine;
  • Antipsychotic medication: chlorpromazine, droperidol, fluphenazine, haloperidol, perphenazine,
  • An mao inhibitor—isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

This list isn't complete. Other drugs can react with epinephrine or articaine, such as prescription and over-the-counter drugs, vitamins, and herbal remedies. The interactions of all potential drugs are mentioned in this medication guide.