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Safetussin PM

Generic name: dextromethorphan and doxylamine [DEX-troe-me-THOR-fan-an-dox-IL-a-meen]
Names of brands: nyquil Cough, Robitussin Maximum Strength Nighttime Cough, Robitussin Nighttime Cough DM Safetussin PM Robitussin Max Strength Nighttime Cough DM
Classification of drugs: upper respiratory combinations

What is Safetussin PM?

Dextromethorphan is an effective cough suppressant. It alters the brain signals that trigger the cough reflex.Doxylamine is an antihistamine that decreases the effects of the natural chemical histamine within the body. Histamine is known to cause nasal congestion, itching, eye watering, and a dry nose.

Sneezing,Safetussin PM is a medicine used nasalt a nasal stuffiness or runny noses. Itching, sneezing and eyes that are watery due to allergies, typical cold as well as influenzasafetussin PM cannot treat a cough resulting from smoke, asthma, or emphysema.Safetussin PM can be used for other purposes not covered in this medication guide.

Side effects of Safetussin PM

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response,or such ahives,s; difficulty breathing, and swelling of your lips, face, or tongue.

Safetussin PM may cause serious side effects. Take off Safetussin PM immediately and contact your doctor immediately in the event that you experience:

  • Severe dizziness or anxiety;
  • An euphoric feeling, similar to when you're about to pass out.
  • Very little or no urine very little or no urine
  • Liver issues: nausea and stomach pains in the upper part of the stomach; fatigue; itching; nausea; loss of appetite, dark stools, clay-colored urine, and jaundice (yellowing of the eyes or skin).

Common adverse reactions to Safetussin PM could include:

  • Drowsiness, dizziness;
  • Nervousness;
  • Sleep problems (insomnia);
  • Being anxious or restless (especially for children).

There isn't an exhaustive description of all negative consequences. Other effects may also be experienced. Consult your physician for advice regarding medical effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Do not take Safetussin PM if you have taken an MAO inhibitor within the last 14 days, like isocarboxazid or linezolid, blue injection, or phenelzine rasagiline, selegiline, or tranylcypromine.

Avoid giving this medicine to children younger than 4 years of age. Always consult with a doctor prior to giving any cold or cough medicine to an infant. Death can occur because of the misuse of cough or cold medications for very young children.It is not recommended to use antihistamine medication to make your child restless.

Before you take this drug

It is not recommended to take this medication if you have an allergy to dextromethorphan or doxylamine.

Don't use Safetussin PM if you've previously taken an MAO inhibitor within the past 14 days. A risky drug interaction may occur. MAO inhibitors include isocarboxazid linezolid, methylene blue injection rasagiline, phenelzine, tranylcypromine, and others.

Don't give this medication to a child who is less than four years old. Always consult a physician prior to giving a cold or cough medicine to children. Death can occur because of the misuse of cold and cough medicines in children who are very young.

It is not recommended to use antihistamine medication to make your child tired.

To ensure Safetussin PM is suitable for you, inform your doctor if:

  • High blood pressure; heart disease;
  • An thyroid disorder;
  • A blockage inside your stomach (stomach and intestines);
  • Kidney or liver disease;
  • Diabetes;
  • Mucusy cough or cough due to the condition emphysema or chronic bronchitis;
  • Bladder obstruction, or other urinary problems;
  • If you are taking potassium (Cytra, Epiklor, K-Lyte, K-Phos Kaon, Klor-Con, Polycitra, and Urocit-K),

It isn't clear if Safetussin PM can cause harm to an unborn baby. Talk to your doctor before you take this medicine if you're expecting.

Doxylamine and dextromethorphan could get through breastmilk and cause harm to a nursing infant. Antihistamines can reduce the production of breast milk. Talk to your doctor prior to taking this medication if you are breastfeeding.

Artificially sweetened cold or cough medicine might contain phenylalanine. If you suffer from phenylketonuria (PKU), be sure to check the label on your medication to determine whether the product contains phenylalanine.

How to take Safetussin PM?

Follow the directions on the label or as recommended by your physician. Don't use it in greater quantities, in smaller amounts, or for a longer period than is recommended. The medicine for a cold or cough is typically taken for a brief period of time until the symptoms subside.

Measure the amount of liquid medicine using the dosing needle provided, a specially designed dosing spoon, or even a medicine cup. If you do not own an instrument for measuring doses, request one from your pharmacist.

Consult your doctor if symptoms don't improve after seven weeks of therapy or if you are suffering from a fever that is accompanied by symptoms such as a headache, cough, or skin rashes.

If you are in need of an operation or other medical examination, notify your doctor or surgeon before the appointment time if you took Safetussin PM in the last few days.Storage at room temperature is free of heat and moisture. Be sure not to let the liquid freeze.

Do I be concerned if I miss a dose?

Because Safetussin PM is prescribed whenever needed, you might not be following a dose schedule. If you're following a schedule, you should take the dose you missed as soon as you can remember. Do not take your missed dose if it's nearing the time for the next dose scheduled. Do not take extra medication to replace the missed dose.

What will happen if I take excessively?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Alcohol consumption can cause an increase in certain negative effects associated with dextromethorphan and doxylamine.

Talk to your doctor or pharmacist prior to using any other cough, cold, allergy, or sleep medication. A number of combination medicines include dextromethorphan and doxylamine. Combining certain medicines can result in you taking excessive amounts of Safetussin PM.

The medicine could cause blurred vision or affect your reactions or thinking. Avoid operating machinery or driving until you understand the effects of Safetussin PM on your vision.

Interaction with other drugs

Talk to your doctor or pharmacist before taking this medication if you're taking other medicines that include prescription or over-the-counter medications, vitamins, and herbal products. Certain medicines may cause undesirable or harmful effects when combined. There are not all the interactions mentioned in this medication guide.

Combining this medication with other drugs that cause you to sleep or cause breathing problems can increase the severity of these effects. Consult your physician before taking Safetussin PM along with sleep pills, opioid pain medication such as muscle relaxers, and medicines that treat depression, anxiety, and seizures.