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Name of The Generic: Mesalamine (oral) (oral) me-SAL-a-meen me-SAL-ah-mean
The Class of Drug: 5-aminosalicylates

What is Apriso?

Apriso is a chemical in the body that causes inflammation in tissues and diarrhea.

Apriso is a treatment for moderate to mild ulcerative colitis in patients aged 18 years and over.

Apriso can be used to prevent ulcerative colitis symptoms from returning.


Stop taking Apriso and consult your physician immediately if you experience an extreme stomach ache or stomach cramps. You may also experience bleeding diarrhea (which may be associated with a headache or fever). migraine as well as skin eruptions).

Before You Take This Drug

It is not recommended to take Apriso in the event that you are allergic to mesalamine, aspirin, or salicylates. (such as Disalcid, Doans Pills, Dolobid Kaopectate, Nuprin backache Pepto-Bismol, Tricosal, Trilisate, and many others).

To be sure Apriso is safe for you, inform your physician if you've previously had:

  • A kidney stone or kidney disease

  • Liver disease;

  • A blockage in your intestines or stomach (such as pyloric theosis) 

  • A skin condition such as eczema.

Apiso capsules contain phenylalanine. Inform your doctor if you suffer from the condition known as phenylketonuria (PKU).

Inform your doctor if you are expecting or planning to be pregnant. It is unclear if mesalamine could harm an unborn baby. If untreated or uncontrolled, ulcerative bowel colitis during pregnancy could result in problems such as low birth weight or premature birth. The benefits of treating ulcerative colitis could outweigh the risks for the infant.

It is not suggested breastfeeding while taking this medicine.

Talk to your doctor about any risks. If you're nursing, inform your doctor if there is diarrhea in your nursing infant.

Avoid giving this medication to the child.

Apriso is not permitted for use by anyone who is younger than 18.

How To Take Apriso?

You should take Apriso exactly as directed by your physician. Follow the instructions on the label of your prescription and study all medication guides or instruction sheets.This medication can alter the results of certain tests. Inform any physician who treats you about your use of mesalamine.

You can take Apriso in combination with or without meals.Drink plenty of fluids in order to avoid kidney stones.Consume the capsule as is; don't chew, open, or break it. Inform your physician if you are having difficulty taking this capsule.

See your doctor if colitis symptoms do not improve or worsen.

This medication can alter the results of medical tests. Be sure to inform any doctor who sees you that you're taking Apriso.You might require regular blood tests to determine the condition of your kidneys or blood cell function.Place it in a cool, dry place free of heat and moisture.

Details on Dosage

Usual Adult Dose for Ulcerative Colitis—Maintenance:

Apriso Extended Release Capsules 375 mg: 1.5 g (4 capsules) daily, orally in the morning


Do not take Apriso 375 mg extended-release capsules with antacids.

Use to maintain remission from ulcerative colitis in adults.

What Happens If I Miss a Dose?

Do not take the medicine for as long as you can. However, avoid any missed doses if you are close to the time of the next dose. Don't take two doses at once.

What Happens If I Overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What Should be Avoided?

If you suffer from any skin conditions, like eczema or eczema-like skin, your skin is more susceptible to sunburn. Avoid tanning beds or sunlight. Be sure to wear protective attire and apply sunblock (SPF 30 or more) whenever you're outside.

Talk to your doctor before using an antacid. Make sure you use only the one that your doctor recommends. Certain anti-inflammatory medications could make it more difficult for your body to absorb mesalamine.

Side Effects of Aprilia

Take immediate medical attention in the event that you exhibit symptoms of an allergic reaction, such as hives, breathing problems, and swelling of your lips, face, and tongue.

Stop taking Apriso and contact your doctor immediately if you suffer from:

  • Severe stomach pain, stomach cramping, bloody diarrhea;

  • Headache, fever, general ill-feeling;

  • Itching, rash; the eye is red;

  • Bloody or tarry stool that coughs up blood or vomit that resembles coffee grounds

  • Lower white blood cell count (fever, chills) skin sores, mouth ulcers, sore throat Cough, feeling lightheaded, and trouble breathing.

  • Symptoms of kidney stones The most severe pain is felt in your back and side, frequently having to urinate, and having smelly urine or dark or cloudy urination.

  • Kidney issues Increased or less frequent urination, swelling, weight gain,

  • Liver issues include lack of appetite and stomach pain fatigue, easy bleeding or bruising in dark urine, black-coloured stool, and jaundice (yellowing of the eyes or skin).

The low white blood cell count could be more prevalent in older adults.

Common side effects of Apriso may include:

  • Burping, constipation, nausea, vomiting, stomach pain, diarrhea, and  gas;

  • Dizziness;

  • Cold symptoms like congestion, sneezing, and a sore throat

  • Lower back pain;

  • Headache;

  • It can be a rash 

  • Unusual liver function tests.

This isn't a complete list of possible side effects, and others could happen.

Consult your doctor for medical advice regarding adverse reactions.

It is possible to report any adverse reaction to FDA by calling 1-800-FDA-1088.


Interaction With Other Drugs

Apriso could affect your kidneys, particularly in conjunction with specific medications for osteoporosis, cancer, infections, rejection of organ transplants, intestinal problems, high blood pressure, or arthritis pain (including Advil, Motrin, and Aleve).

Discuss with your doctor all other medicines you take, particularly:

  • Azathioprine or 6-mercaptopurine.

This list is not comprehensive. Other medications can interfere with mesalamine. These include medications that are prescribed and available over the counter, vitamins, and herbal pro


. Some interactions with drugs may not be listed here. are included here.




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