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Name of generic: Efavirenz, lamivudine, the tenofovir ([ef-AV-ir-enz, lamivudine ef-AV-ir, la-MIV-uedeen, and ten-OF-oh vir“ef-AV-ir”-enz, lamivudine)
The brand names are Symfi and Symfi Lo.
Drug class: Antiviral combinations

What is Symfi?

Symfi is a mix consisting of the drugs efavirenz, lamivudine, and tenofovir. Efavirenz, lamivudine, and tenofovir can be considered antiviral medications that stop the human immunodeficiency virus (HIV) from multiplying throughout your body. HIV is a virus that causes acquired immunodeficiency disorder (AIDS). This medication isn't an effective treatment for HIV and AIDS. Symfi can be used by children and adults who weigh at least 88 lbs (40 kg).  Symfi Lo is recommended for use by adults and children with a weight of at least 77 lbs (35 kg).


Symfi could trigger a dangerous disease known as lactic acidosis, which can lead to a serious buildup of lactic acids inside your blood. Contact your physician or seek medical attention immediately if you experience an unusually painful muscle, difficulty breathing, stomach pains, dizziness, feeling cold, extremely tired, or weakness.

Contact your doctor immediately if you experience an increase in pain or swelling in your stomach, unusual fatigue, or a loss of appetite. black stools, dark urine, or a yellowing of the eyes or skin. Symfi may cause serious mental health problems. Seek medical attention in the event of strange sadness, paranoia, hallucinations, or thoughts of harming yourself or someone else. If you've had any experience with the virus known as hepatitis B or C, it could get more active or worse when you stop taking Symfi. You could require regular tests of your liver's function for many months. Do not alter your dosage or discontinue taking this medication without a prescription from your doctor.

Before you take this drug

Symfi should not be used. Symfi If:

  • You can also take elbasvir as well as grazoprevir (for hepatitis C), as well as

  • You are intolerant to any combination of antiviral medication that contains efavirenz, lamivudine, or tenofovir.

To ensure that Symfi is safe for you, inform your doctor if you have ever experienced:

  • Liver disease (especially liver disease, especially hepatitis B as well as C) or

  • Renal disease (or if you're taking dialysis);

  • Heart issues;

  • The long QT disorder (in the case of you as well as a relative);

  • Addiction to alcohol or drugs;

  • A seizure; or

  • Fractures, or other issues related to bones.

There is a chance that you will be diagnosed with the condition known as lactic acidosis. It is a risky buildup of lactic acid within your blood. It's more likely in the case of an obese person or a female. Consult your physician about the chances of developing the disease.

You might need to undergo an unfavourable pregnancy test prior to commencing this treatment. Do not take Symfi in the event that you are expecting. It could harm the unborn baby or cause birth defects. Utilise effective birth control to avoid pregnancy while using this medication and for a minimum of 12 weeks after the last dose. Utilise two birth control methods to stop pregnancy, such as a barrier type like a condom diaphragm or cervical cap, as well as a contraceptive gel. If you're expecting and you are a registered mother, your name could be added to the registry for pregnancy to monitor the effect of Symfi on the infant. Women who have HIV or AIDS are not allowed to breastfeed their babies. Even if your child is born without HIV or AIDS, the virus could be passed on to the child by the milk you give your baby.

How to take Symfi?

You should take Symfi exactly as directed by your physician. Follow all instructions on your prescription label, and review all medication guides and instructions on the label. Symfi is an all-inclusive regimen and should not be used alongside other antiviral medications. Consume Symfi with a full stomach before bedtime. You'll require frequent medical examinations. Do not alter the dose or frequency of your dosing without your doctor's guidance. Everyone suffering from HIV must remain under the supervision of a physician.

Place the medicine in the original container at room temperature, away from heat and moisture. If you've had any experience with the virus hepatitis B, the virus could be active or become more severe within the following months after you stop taking Symfi. It is possible that you will require regular liver function checks for a few months following your last dose.

Details on dosage

Usual Adult Dose for HIV Infection:

1 tablet, orally, once a day

Use as a full regimen to treat HIV-1 infection.

Usual Paediatric Dose for HIV Infection:

1 tablet, orally, once a day


Symfi Lo is recommended for patients who weigh at least 35kg.

Symfi is approved for patients who weigh more than 40 kilograms.

Recommend for children who have the ability to swallow solid tablets.

Use as a complete treatment to treat HIV-1 infection.

What happens If I miss a dose?

You should take the medication as quickly as you can. However, do not take your missed dose if it's close to the time of the next dose. Don't take two doses at a time.Make sure you refill your prescription before you run out of medication completely.

What happens If I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Beware of eating or drinking any drink that contains sorbitol (an artificial sweetener). Avoid driving and other hazardous activities until you understand the effects this medicine has on your body. Your reaction could be affected.

Side Effects of Symfi

See a doctor immediately when you notice symptoms that indicate an allergic reaction. Symfi (hives, breathing problems, and swelling of your throat or face) or an extreme skin reaction (fever or burning sensations in your eyes, pain in your skin, and a red or purple itching that can cause peeling and blisters)

Contact your doctor immediately if you are suffering from:

  • Extreme disorientation or drowsiness; concentration; bizarre dreams;

  • issues with thinking, confusion, and hearing or seeing things that aren't real (may take months or even years after taking this medication);

  • Heartbeats that are fast or rapid, chest fluttering, and an abrupt dizziness (like you're going to faint);

  • Difficulties with balance and coordination issues;

  • Acute or new bone pain that is either new or worsening;
  • the pain in your legs, arms, or hands;
  • Lactic acidosis: muscle pain that is unusually difficult to breathe; stomach pain; vomiting; irregular heart rate; nausea; feeling cold; or feeling extremely tired or weak.
  • Pancreatitis A severe pain in your upper stomach, spreading into the back of your body, nausea, and even vomiting;
  • Strange thoughts fear, paranoia feelings of sadness or despair; thoughts of harming yourself or others;
  • Liver issues;

    the midsection area is swelling; upper stomach pain; excessive tiredness; loss of appetite. dark urine, a clay-coloured stool, and jaundice (yellowing of the eyes or skin).

Symfi can affect the immune system and could cause some side effects (even months or weeks after you've taken the medicine). Inform your doctor whether you suffer from:

  • Symptoms of signs of a new infection like night sweets, glands that are swollen, cold sores, cough, wheezing, vomiting, and weight loss;

  • Difficulty swallowing or speaking difficulties with balance, eye movement, weak or prickly sensations, swallowing, or speaking;

  • Swelling in your throat or neck (enlarged thyroid) Menstrual fluctuations, impotence

Common Symfi adverse effects could be:

  • Headache, dizziness;

  • Depression and thnking issues;

  • Nausea, diarrhoea;

  • Sleep problems (insomnia);

  • Pain;

  • Weakness, 

  • Tiredness;

  • Congestion, a stuffy nose, sinus pain, cough,

  • The rash or

  • Modifications in the appearance or shape of fat (especially on your arms, legs, face, neck, breasts, and waist).

This isn't an exhaustive list of possible side effects, and others could happen. Contact your doctor for advice regarding medical effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

There are times when it's not recommended to take certain medicines together. Certain medications can alter the blood levels and the other drugs that you take, which can create side effects or render the drugs less effective.

A variety of drugs can cause interactions with lamivudine, efavirenz, and tenofovir. This includes over-the-counter and prescription drugs, vitamins, and herbal supplements. Not all interactions are mentioned here. Inform your doctor of your current medications and any medications you begin or stop taking.