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Atropine and pralidoxime

Generic name: atropine and pralidoxime [AT-roe-peen-and-PRAL-i-DOX-eem]
Brand names: ATNAA, DuoDote
Dosage form: intramuscular solution ranging from 2.1 mg/0.7 mL-600 mg/2 mL).
Drug class: antidotes

What is Atropine and pralidoxime?

Atropine and pralidoxime are combination drugs that are used to treat poisoning from pesticides (insect spray) or any chemical that affects your central nervous system, for example, nerve gas.Atropine and pralidoxime aren't efficient as an antidote against the various pesticide poisonings. It is possible that you will require medication or other treatments.Atropine and Pralidoxime can be used to treat conditions not covered in this medication guideline.

Side effects of Atropine and pralidoxime

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergy, such as asthma, hives, and swelling of your lips, face, and tongue,Some of the effects of atropine or pralidoxime could be similar to those of poisoning. Your healthcare providers will be watching closely to see if the body's response is positive to the medication or if you're experiencing any serious adverse side effects.

Contact your family carers immediately. If you suffer from:

  • Do your heartbeats pound or flutter in your chest?
  • Chest pain, which is spreading to your shoulder or jaw;
  • Difficulty swallowing
  • Urination that is painful or difficult
  • Minimal or no urination
  • Unexpected changes in behaviour or mood and
  • Blurred vision blurred vision, tunnel vision, eye pain, or seeing halos of light

The risk of side effects is more common in older people.

Common adverse effects of atropine and pralidoxime could include:

  • Trouble breathing
  • Dry mouth;
  • Dry eyes, changes in vision, and being more sensitive to light
  • Nausea, vomiting;
  • High heart rate, increased blood pressure
  • If your behaviour changes, you may feel overwhelmed or confused.
  • Less frequent urination;
  • Headache, dizziness, drowsiness;
  • Muscles weak;
  • Dry skin pimples;
  • Unusual liver function tests.

These side effects are by no means exhaustive and others could arise as well. Contact your doctor for advice regarding medical effects. Report any side effects directly to the FDA at 1-800-FDA-1088.


In an emergency situation, you might not be able to inform doctors about your medical conditions. Be sure that any physician caring for you following the incident knows that you have received pralidoxime and atropine.

Prior to using this drug

If possible, prior to the time you start taking atropine or pralidoxime, inform your doctor if you've previously had:

  • A possible allergy or sensitivity to medication
  • Heart conditions or a heart attack and stroke;
  • Hypertension;
  • Kidney or liver disease;
  • Asthma, COPD (chronic obstruction pulmonary disorder), or any other breathing issues;
  • Glaucoma;
  • Urination issues.

In an emergency, it might not be possible to notify your carers that you are nursing or pregnant. It is important that the doctor caring for your baby or your pregnant mother be informed that you've taken this medication.

How do I take Atropine and pralidoxime?

Atropine and Pralidoxime are injectable into the muscles of the upper thigh. An injection will be given by a healthcare provider.Atropine and pralidoxime are typically administered as soon as possible following the onset of poisoning symptoms. If you are still experiencing symptoms within 10 to 15 minutes, the patient will be given two additional injections.Your blood pressure, breathing levels, kidney function, oxygen levels, and many other vital indicators will be closely monitored.You can be observed throughout the course of up to 72 hours in order to confirm that the treatment has worked and that you aren't suffering any negative effects from the poison.

What happens if I miss the dose?

Because atropine and pralidoxime are employed when required, however, there isn't any daily dosing regimen.

What happens if I overdose?

Because this medication is administered by a health specialist in a medical setting, it is highly unlikely for an overdose to occur.The risk of overdose is higher when you take atropine or pralidoxime and haven't really been exposed to the particular poisons this medication is intended to treat. The symptoms could include vision issues or a feeling of instability, loss of balance or coordination issues, difficulty in concentration, rapid heart rate as well as hallucinations, confusion (seeing or hearing sounds), as well as decreased sweating, dry and hot skin, fainting, slow breathing, or breathing that ceases.

Aviod this

Beware of becoming dehydrated or overheated when exercising and during hot temperatures. Atropine is a stimulant that can reduce sweating. You could be more susceptible to suffering from heat stroke for a brief period following the administration of this medication.

Interaction with other drug

Other medications can affect pralidoxime and atropine, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. If you are able, prior to the time you take atropine or pralidoxime, inform your physician about all the medications you are currently taking.