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Abiraterone

Generic Name: Abiraterone acetate [A-bir-A-tee-rone] A-bir-A-tee-rone
The Brand Names are Yonsa and Zytiga.
Dosage Format: Oral tablet (125 mg, 250 mg, 500 mg)
The Class of Drug: Miscellaneous antineoplastics

What is Abiraterone?

Abiraterone

reduces androgen production within the body. The hormones known as androgens can be male hormones that may cause the growth of tumors in prostate gland.

Abiraterone can be used in conjunction with steroids (prednisone or methylprednisolone) to treat prostate cancer, which can spread to various areas of the body. Abiraterone is prescribed to those who have prostate cancer that cannot be treated through surgery or other treatments. It isn't clear whether abiraterone acetate tablets can be considered safe or effective for children or females.

Warning

Tablets of abiraterone should not be administered to pregnant women or those who might be expecting

.

This medicine can cause harm to an unborn baby and cause miscarriage.

It is not recommended to use abiraterone when you are allergic to it.

Before you take this medicine, consult your doctor

.

Abiraterone should not be used by children or women. To ensure that this medication is suitable for you, inform your physician if you've previously had:

  • Liver disease;

  • Diabetes (especially when you take pioglitazone or repaglinide);

  • Heart conditions, high blood pressure;

  • A heart attack;

  • In your blood, you have low potassium levels. or

  • Troubles with your adrenal gland, or pituitary gland.

Abiraterone could harm the baby's unborn when a mother has contact with it while pregnant. The tablet containing abiraterone is not recommended for women who are expecting or who are pregnant. The medicine from the tablet that has been broken can be absorbed by the skin.

Abiraterone may cause harm to a baby who is not yet born when the father is taking the medication during the moment of conception or pregnancy.Make sure you are using effective birth control when your partner is pregnant or has the potential to become pregnant. Use birth control for a minimum of 3 weeks following the last dose.

Before you Take this Drug?

Administer abiraterone according to the prescription given by your physician. Follow the instructions on the label of your prescription and study the entire medication guide or instruction sheet.Abiraterone is typically taken once daily, and you can also take a steroid one or two times every day. Follow the instructions of your doctor for dosing extremely carefully.

The dose of abiraterone that you need may alter if you switch to a new brand, strength, or type of this drug. Make sure you are using only the medicine that your doctor has prescribed.The dose of methylprednisolone or prednisone you receive could change if you have an infection or are experiencing pressure. Do not alter the dosage or stop taking your steroid medications without a doctor's recommendation.

Consume this medicine along with a bottle of water. You can consume Yonsa without or with food.

It is advised to consume Zytiga in an empty stomach.

Don't eat anything for at least two hours prior to or for one hour following the taking of Zytiga. Suck the tablet completely and don't chew, crush, or break it.

Your blood pressure is likely to be checked frequently, and you could require regular blood tests. If you are diabetic, your blood sugar needs to be monitored carefully, particularly in the case of pioglitazone and repaglinide.

You shouldn't stop using abiraterone or any steroid medication immediately. Follow the advice of your doctor on tapering the dose of prednisone.Place it in a cool, dry place far from heat and moisture.

Details on Dosage

Usual Adult Dose for Prostate Cancer

Metastatic CRPC:

Regular formulation: 1000 mg taken orally every day (in combination with methylprednisolone, 5 mg daily orally)

A micronized formulation of 500 mg taken orally each day (in combination with methylprednisolone, 4 mg orally twice daily)

Uses:

Prednisone is used in conjunction with prednisone to aid in treating patients suffering from:

Metastatic castration-resistant prostate cancer (CRPC)

Metastatic high-risk prostate cancer that is castration-sensitive (CSPC)

What Happens If I Miss a Dose?

Don't miss the missed dose; take the medication the next day. Don't take two doses at once.Consult your physician for advice in the event that you missed at least one dose of abiraterone.

What Happens If I Overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What Should Be Avoided?

Avoid eating food for a minimum of 2 hours prior to taking Zytiga or for at least one hour after taking your dose. Foods can increase the levels of Zytiga the body absorbs and could cause unwanted and undesirable side effects.

Side Effects of Abiraterone 

Contact a medical professional immediately. If you exhibit symptoms that indicate an allergy reaction, Abiraterone: hives or difficulty breathing and swelling of your lips, face, tongue, throat, or face

See your doctor right away. If you suffer from:

  • The swelling of your ankles, feet, or legs; leg pain;

  • Irregular or rapid heartbeats;

  • A feeling of lightheadedness, as if you're about to pass out.

  • A severe headache severe headache, blurred vision, the pounding of your neck or in your ears;

  • Discomfort or burning sensation after you urinate;

  • Low red blood cells (anemia)

    :

    pale skin, fatigue, lightheadedness or breathlessness, cold feet and hands;

  • Lower blood potassium Leg cramps, constipation, irregular heartbeats, fluttering around your chest, thirsty or increased urine, numbness or tenderness in muscles, or a limp sensation;

  • Liver issues nausea (upper right side), nausea, vomiting, dark urine, jaundice (yellowing of the eyes or skin),

Common side effects of abiraterone include:

  • Feeling extremely tired or weak;

  • Feeling very hot;

  • High blood sugar levels;

  • Elevated blood pressure

  • Swelling in your feet or legs;

  • Anemia or low blood potassium levels;

  • Painful urination;

  • Abnormal tests for liver function or different blood tests

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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