What is Abilify Asimtufii?
The Abilify Asimtufii can be described as an antipsychotic that is atypically used to treat schizophrenia and bipolar I disorder in adults. and bipolar I disorder in adults. Asimtufii has an extended-release infusion which is administered once every two months.
The precise way Abilify Asimtufii works (the mechanism that causes action) to treat bipolar I disorder is not understood. However, it is believed to work by balancing dopamine and serotonin levels within the brain.
The drug Abilify (Aripiprazole) can also be purchased as Abilify (oral tablets), Abilify MyCite (tablet that is equipped with an ingestion sensor) as well as Abilify Maintena (an extended-release injection that can be administered once a month).
The Abilify Asimtufii is a slow-release with a longer-acting injection administered every two months. This aids in compliance, and patients require only six injections yearly.
Warnings
Patients who have a mental illness or depression might contemplate suicide. Certain young people may experience more suicidal thoughts after taking medication to treat depression. If you detect any sudden changes in your mood or suicidal thoughts, contact your doctor right away.
Don't stop taking Aripiprazole abruptly, as you could experience uncomfortable withdrawal effects.
Avoid driving or performing other actions or tasks that require your attention or to have clear eyesight until you understand how Aripiprazole can affect you.
Diabetes, high blood sugar, high cholesterol, and weight gain have occurred due to medications like this. These can increase the chance of brain and heart blood vessel diseases.
A low white blood cell count can be seen with such medications. This could increase the risk of contracting an infection. In rare cases, infections can be devastating. Consult your physician if you have ever experienced a decrease in your white blood cell count. Contact your doctor immediately when you notice symptoms of infection, such as chills, fever, and sore throat.
Similar/related drugs
Quetiapine, lamotrigine, Abilify, Seroquel, Aripiprazole, olanzapine, and risperidone
It is not recommended to take this medicine if you are sensitive to the active ingredient, Aripiprazole, or other inactive components.
This medicine could increase the risk of dying for older adults who have psychosis relating to dementia. However, it isn't permitted for use in this manner.
To ensure that Abilify Asimtufii is suitable for you, inform your physician if you suffer from the following:
- Heart issues or stroke
- Blood pressure (or lower blood pressure;
- Diabetes (in the relative's member);
- Seizures; or
- Low white blood cell (WBC) count.
Suicide may be considered by patients suffering from mental illness or depression. Young people might experience more suicidal thoughts after beginning treatment for depression. Be aware of fluctuations in mood or signs. Family members or caregivers must also be on the lookout for unexpected changes in your behavior.
This medication has the potential to produce high blood sugar levels (hyperglycemia). If you have diabetes, check your sugar level with care.
Pregnancy
Inform your doctor that you are pregnant or planning to be pregnant. This medication could harm the unborn baby. Taking this medication during the third trimester of your pregnancy can cause your baby to exhibit unusual muscle movements or withdrawal symptoms following the birth. Consult your doctor about the potential risk to your baby's future when taking this medication during pregnancy. Do not discontinue the drug without first visiting your doctor.
Contact your healthcare provider immediately if you become pregnant or suspect you're pregnant during treatment. If you become pregnant while undergoing therapy, talk to your doctor about joining the Pregnancy Registry of America for Atypical Antipsychotics. Call 1-866-961-2388 or go to http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/ to register.
Breastfeeding
Inform your doctor whether you're nursing or planning to breastfeed. The medicine can be passed through your breast milk, and it's unclear whether it could harm the baby. Discuss with your healthcare professional the best way to feed your child while receiving treatment.
What is Abilify? Asimtufii provided?
If you have never used Aripiprazole, it is essential to test their tolerance with oral Aripiprazole before introducing treatment using this injection. Because of the half-life of oral Aripiprazole, it can take as long as two weeks to determine tolerance.
Abilify Asimtufii is an injection to your buttock muscles by your physician. Don't administer it through any other means.
Abilify Asimtufii is prescribed once every two months.
Patients Receiving Oral Antipsychotics
If Abilify Asimtufii injectable is started in patients taking oral aripiprazole, administer the initial dose of Abilify Asimtufii alongside oral Aripiprazole (10 mg to 20 mg) for 14 consecutive days.
For stable patients on an oral antipsychotic (known to be tolerant of Aripiprazole), start by administering the first Abilify Asimtufii infusion alongside the antipsychotic oral for fourteen days.
Patients Receiving Abilify Maintena
Patients who get Abilify Maintena (once a month dosing) are given Abilify Asimtufii at 960 mg (one every two months dosing) instead of the next Abilify Maintena injection. The initial Abilify Asimtufii dose can be administered instead of the second or later injection of Abilify Maintena.
If there are any adverse reactions to the 960 mg dosage, it can be decreased to 720 mg every two months.
Patients could receive the Abilify Asimtufii injectable up to two weeks prior or two weeks following the time-scheduled 2-month date.
Details on Dosage
Usual Abilify Asimtufii Adult Dose for Schizophrenia
A dose of 960 mg is given at least every two months in one injection.
Utilization: for the treatment of schizophrenia in adults.
Comments:
- The dose may be reduced to 720 mg for patients with adverse reactions.
- In patients who are naive or unable to tolerate Aripiprazole treatment, test for tolerability by taking oral Aripiprazole before beginning treatment.
- Inject intramuscularly into the gluteal muscles by medical professionals.
- Don't administer any other means.
Adult Abilify Asimtufii Dose Usual for Bipolar I Disorder
Dosage: 960 mg is given each time every two months as one injection.
Utilization: Maintenance monotherapy treatment of bipolar I disorder for adults.
Comments:
- The dose may be reduced to 720 mg for patients with adverse reactions.
- In patients who are naive or unable to tolerate Aripiprazole treatment, test for tolerability by taking oral Aripiprazole before beginning treatment.
- Inject intramuscularly into the gluteal muscles by an experienced healthcare professional. Don't administer via any other means.
What Happens If I Miss a Dose?
If more than eight weeks or less than 14 days have passed between the last injection, administer the next dose as soon as you can—the two-monthly, once every two months schedule should be reintroduced.
If it has been more than fourteen weeks since the last injection, re-inject the concurrent oral aripiprazole medication for 14 days before the next injection.
Before you Take this medication
Do not get up too quickly from lying or sitting in a position where you get dizzy. Avoid driving or engaging in hazardous activities until you understand the effects of Aripiprazole on your body. Dizziness or drowsiness may result in falls, accidents, or serious injuries.
Avoid driving a car, operating machinery, or performing other hazardous activities until you understand how this medicine affects you. The medicine could affect your thinking, judgment, or motor abilities.
Beware of drinking alcohol. Potentially dangerous side effects can result.
When you take Aripiprazole, it might be more sensitive to extreme heat. Avoid becoming too hot or dehydrated. Get plenty of fluids, particularly in hot weather and when exercising.
Side effects of Abilify Asimtufii
Take immediate medical attention If you notice symptoms of an allergic reaction to Aripiprazole, such as itching and breathing problems and swelling of your lips, face, and tongue.
Contact your physician immediately when you notice any abrupt or new changes in your mood or behavior, such as more or worse depression, anxiety, panic attacks, and trouble sleeping, or if you experience uncontrollably angry, frustration, or aggression. Anxiety, increased activity or talkativeness, or suicidal or self-harming thoughts.
Consult your physician immediately if you are suffering from the following:
- Intense disturbance, dismay, agitation, or an uneasy feeling;
- The uncontrollable twitching of your lips, eyes, and tongues, your arms or legs;
- The appearance of the face is like a mask facial mask, difficulty swallowing, difficulties with speech;
- seizure (convulsions);
- Extreme nervous system reaction, extremely rigid (rigid) muscles and sweating, high fever and confusion, rapid or irregular heartbeats, or the sensation that you may faint;
- Low blood cell counts – chills, fever, sore throat weakening, easy bruising bleeding, unusual or red spots beneath your skin, or
- Blood sugar levels are high - it can cause increased thirst and urination rate, the mouth is dry, and there's fruity.
You might experience more sexual urges, unusual cravings for gambling, and any other intense desires while taking this medicine. Discuss this with your doctor in the event of this.
Mild Abilify Asimtufii side effects can include the following:
- Blurred vision
- More saliva or excessive salivation or;
- Muscle stiffness;
- Uncontrolled muscle movements, shaking, anxiety, feeling restless;
- Weight gain
- Nausea, vomiting, constipation;
- Increased or decreased appetite
- Headache, dizziness, drowsiness, and fatigue;
- Sleep problems (insomnia); or
- Cold symptoms like nasal stuffiness, sneezing, sore throats;
This is a partial list of all side effects. Other side effects could occur. Contact your doctor for advice regarding medical adverse effects. Any symptoms should be reported to the FDA at 1-800-FDA-1088.
Interaction with Other Drugs
Talk to your doctor about every medication you are taking that you are taking, including prescription drugs and prescription medications such as vitamins and herbal supplements.
The Abilify Asimtufii and other medicines could interact with each other, resulting in dangerous adverse consequences. This medication could alter the way other medicines function and vice versa.
Your doctor can inform you whether taking this injection and other medications is safe. Do not stop or begin medication during treatment without consulting with your doctor.
Take note of the medicines you are taking. Make a list to show your doctor and pharmacist if you are prescribed a new medication.
Inform your healthcare provider that you are taking any of the following medications:
- Clarithromycin (Biaxin)
- Antidepressants like fluoxetine (Prozac) as well as paroxetine (Paxil), and Nefazodone
- Antifungals like fluconazole (Diflucan) ketoconazole (Nizoral) as well as itraconazole (Sporanox)
- Quinidine
- HIV drugs like indinavir (Crixivan) and the ritonavir (Norvir) and Saquinavir (Fortova, Invirase), and lopinavir/ritonavir (Kaletra)
- Carbamazepine (Tegretol)
- Rifampin (Rifadin).
