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Genric Name: filgrastim [fil-GRAS-tim]
Brand names: Neupogen, Neupogen SingleJect, Nivestym, Releuko, Zarxio
Dosage form: injectable solution (300 mcg/0.5 mL; 300 mcg/mL; 480 mcg/0.8 mL; 480 mcg/1.6 mL; aafi 300 mcg/0.5 mL; aafi 300 mcg/mL; aafi 480 mcg/0.8 mL; aafi 480 mcg/1.6 mL; ayow 300 mcg/0.5 mL; ayow 300 mcg/0.5 mL; ayow 300 mL; ayow 480 mcg/0.8 mL; sndz 300 mcg/0.5 mL; sndz 480 mcg/0.8 mL;
Drug class: colony-stimulating factors

What is Filgrastim?

Filgrastim is a treatment for neutropenia (lack of certain white blood cells) in patients who are taking particular cancer drugs, who are undergoing a bone marrow transplant, or who are triggered by other ailments. Neupogen, Zarxio, and Nivestym can be utilised in a process known as leukapheresis. This is a procedure where the white blood cells that are required to support the transplantation of stem cells are taken out of the body. Neupogen is also used in patients who have been exposed to a specific dose of radiation. Filgrastim is also employed for reasons not mentioned in this guideline.

Side effects of Filgrastim

Take immediate medical care. If you notice symptoms that are warning signs of an allergic reaction, such as itching, sweating, and dizziness, rapid beat, wheezing, difficulty breathing, and swelling of your lips, face, or tongue.

Filgrastim could cause a serious lung condition known as acute respiratory distress syndrome (ARDS) and an uncommon but dangerous side effect known as the capillary leak. Call your doctor or seek medical emergency attention immediately if you experience fever, breath shortness, or rapid breathing. runny or stuffy nose, fatigue or thirst, less frequency of urination, rapid weight gain, or swelling Filgrastim could cause your spleen to grow larger and cause it to tear. Call your doctor immediately if you are experiencing left-sided upper stomach discomfort or shoulder pain. There are some side effects that can happen when you inject. Inform your physician when you feel faint, dizzy, nauseated, or sweaty. or experience headaches, chest tightness, back discomfort, breathing difficulties, or swelling on your face. Filgrastim may cause serious side effects. Contact your doctor immediately. If you suffer from:

  • Simple bleeding, unusual bruising, bloody spots that are red or purple, on the skin, or under your skin
  • Fever, tiredness, stomach pain, back pain;
  • Indications warnings the sickle-cell anemia emergency: difficulty breathing or pain;
  • An inflammation of the blood vessels in your body, numbness or itching, skin rash, headache, fever, body aches, night sweats, losing weight, or feeling fatigued or weak
  • Kidney problems: swelling, less frequent urination, fatigue, or feeling exhausted.

Common adverse effects of filgrastim include:

  • Pain, fever, cough, difficulty breathing;
  • Nosebleeds;
  • Anaemia (low red blood cells);
  • Bone pain;
  • Diarrhoea;
  • Headache;
  • Numbness
  • Rash
  • Hair loss.

This is not a comprehensive list of all the side effects. Other effects may also be present. Consult your physician for advice regarding medical adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


Filgrastim could cause serious lung problems known as acute respiratory distress syndrome (ARDS) and an uncommon but serious side effect known as the capillary leak. Call your doctor or seek medical attention in an emergency immediately if you experience an increase in temperature, breathing problems, shortness of breath or rapid breathing, a runny or stuffy nose that is followed by fatigue or thirst, less urine output, or rapid weight gain or swelling.

Filgrastim could cause your spleen to grow larger and break (tear). Call your doctor immediately if you experience left-sided stomach discomfort or shoulder pain.

Before taking this drug

Filgrastim is not a good choice in the event that you are allergic to filgrastim or another stimulant of the colon, granulocytes, like pegfilgrastim, tbo-filgrastim, sargramostim, or eflapegrastim. The use of filgrastim could increase the chance of developing myelodysplastic disorder (MDS) or acute myeloid leukaemia (AML) in the case of specific medical health conditions. Consult your physician regarding the possibility.

Inform your doctor if you are or have ever experienced:

  • Sickle cell anaemia (a haemoglobin blood cell disorder);
  • Latex allergies
  • Radiation treatment radiation treatment
  • Kidney disease.

It is unknown whether filgrastim can harm an unborn baby. Inform your doctor if you are expecting or planning to be pregnant. Consult your doctor to determine whether it is safe to breastfeed while taking this medication.

How to take Filgrastim?

Follow the instructions on the label of your prescription and read the medication guide or instructions sheets. The doctor might alter the dosage. Follow the medication precisely as directed. Filgrastim is injected into the skin or into veins. Healthcare professionals can instruct you or a family member on how to use this drug at home. Doses are determined by weight. Your dose may change if you gain or lose weight. Your physician will inform you of the best place to inject filgrastim. Don't inject in the same area twice in the same row. Don't inject into areas of the skin that are sensitive, bruised, hard, or red. Avoid injecting into skin that is prone to stretch marks or scars. Do not alter your dosage or stop using medication without consulting your physician. The dosage you require may be altered if you change the strength, brand, or type of medication. Be sure to use only the medication prescribed by your physician. Don't change brands without consulting your physician. Talk to your pharmacist or doctor. If you're not sure how to make an injection, Make an injection when you're ready to administer it. Inform your pharmacist if the medicine is cloudy, appears to have changed color, or contains particles. Don't reuse needles or syringes. Put them in a puncture-proof "sharps" container and dispose of them in accordance with local or state laws. Keep them out of the reach of pets and children. Your blood must be checked frequently. It is possible that you will require medical tests to determine how long you need to use filgrastim.

This medicine may affect the outcomes of certain medical tests. Be sure to inform any doctor treating patients that you're using filgrastim. Place the filgrastim in the original container in the refrigerator in a dark place, far from light. Avoid freezing, and don't shake. Do not heat the medication with sunlight, hot water, or even a microwave. Remove the medicine from the refrigerator and allow it to be at ambient temperature for 30 minutes before you use it. Don't keep Neupogen, Nivestim, or Releuko out for more than 24 hours. Don't allow Zarxio to be in the sun for more than 4 days. Toss out a syringe that has been filled or a vial (bottle) after a single use, even if there's remaining medicine inside.

What happens If I overdose?

Contact your doctor for advice if you missed the dose.

What happens If I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Beware of those with illnesses or who suffer from infections. Contact your doctor right away in the event that you show symptoms of an infection.

Interaction with other drugs

Do not take filgrastim for the first 24 hours before or following the treatment or for 24 hours following the bone marrow transplant. Other medications can affect filgrastim's effects, including prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about any other medications you are taking.