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Endocet 2.5/325

Generic name: acetaminophen and oxycodone [a-SEET-a-MIN-oh-fen-and-OX-i-KOE-done]

Brand names: Endocet 10/325, Endocet 2.5/325, Endocet 5/325, Endocet 7.5/325, Nalocet,… show all 8 brands
Drug class: narcotic analgesic combinations

What is Endocet 2.5/325?

Endocet 2.5/325 is a combination medicine designed to relieve moderate to severe pain. Containing an opioid medicine, Endocet 2.5/325 may become habit-forming; additionally, Endocet 2.5/325 may also be used for purposes not listed here.

Side effects of Endocet 2.5/325

Contact a medical professional immediately. If you are experiencing warning signs of an allergic reaction, such as symptoms of hives, breathing difficulties, and swelling of your lips, face, and tongue,Opioid medication may slow or stop breathing, and death can occur. The person who is caring for you should administer Naloxone or seek medical attention if you experience prolonged breathing, pauses in your breathing, blue-colored lips, or if it is difficult to get up.

In rare instances, acetaminophen can cause a serious skin reaction that can cause death. This could occur regardless of whether you've previously used acetaminophen and did not experience any reaction. Do not take Endocet 2.5/325, and consult your physician immediately if you notice the appearance of a skin rash or redness that gets worse and leads to blisters or peeling.Endocet 2.5/325 may cause serious side effects. Contact your physician immediately. If you suffer from:

  • Sighing, noisy breathing, breathing shallowly, and breathing that ceases
  • Feeling dizzy and lightheaded, like you may pass out.
  • Tiredness, weakness, fever, bleeding, or swelling that is unusual;
  • The mind, or unusual thoughts or behaviors;
  • Issues with urination;
  • Liver issues liver problems: nausea and stomach pains in the upper region; fatigue; lack of appetite black stools, dark urine, and jaundice (yellowing of the eyes or skin);
  • Low levels of cortisol nausea nausea, vomiting, nausea, vomiting, dizziness, fatigue that is worsening, or weakness
  • Serotonin levels that are elevated within the body—the body's serotonin levels can cause agitation, hallucinations, fever, sweating, shaking, a fast heart rate, and muscle stiffness.Shaking, loss of coordination, nausea, vomiting and diarrhea.

The presence of serious breathing issues is more prevalent in older people and those who are disabled or suffer from an underlying condition called wasting syndrome, as well as chronic respiratory conditions.

Common side effects are:

  • Nausea, dizziness, fatigue, dizziness;
  • Feelings of extreme sadness or joy;
  • Nausea, vomiting, and stomach pain;
  • Constipation

This isn't a complete list of all the side effects. Other side effects could occur. Contact your physician to seek medical advice on the effects. Report any adverse side effects directly to the FDA by calling their toll-free number: 1-800-FDA-1088.


A careless use of opioid medication could lead to addiction, overdose, or even death. Keep the medication in a location where other people are unable to access it.Opioid medicine taken during pregnancy can result in life-threatening withdrawal symptoms for the infant.The risk of fatal side effects could be experienced if you take opioids in conjunction with alcohol or with other medications that cause drowsiness or slow respiration.Do not take this medication, and contact your doctor immediately if you notice a rash or skin redness that gets worse and leads to blisters or the skin peeling.

Before you take this drug

It is not recommended to take Endocet 2.5/325. If you are sensitive to acetaminophen or oxycodone or suffer from:

  • Serious, severe asthma or breathing issues severe asthma or breathing problems.
  • Obstruction in your stomach or the intestines.

Speak to your doctor if you ever have:

  • Breathing issues, sleep apnea;
  • The liver condition;
  • An addiction to alcohol or drugs;
  • Kidney disease;
  • A head injury or seizures;
  • Urination issues
  • Issues related to your pancreas, thyroid, or gallbladder.

If you take opioids while pregnant, your baby may develop a dependence on the medication. This can cause severe withdrawal symptoms for the newborn after it's born. Babies born dependent on opioids may need medical treatment for several weeks.Consult a physician before using opioid medications in the case of nursing. Tell your doctor if you notice a sudden increase in sleepiness or slow breathing during the breastfeeding period.

How to take Endocet 2.5/325?

Follow the instructions on the prescription label. Do not take this medication in greater quantities or for longer than the time prescribed. An overdose can damage your liver or cause death.Consult your physician if you notice an increase in your desire to take more medication.Don't share opioids with a person, especially one who has an addiction history. Misuse can cause addiction, overdose, or death. Place the medication at a location where others are unable to access it. The act of selling or giving away opioids is against the law.Make sure to measure the liquid medicine with care. Make use of the dosing syringe supplied or a dosage-monitoring device (not an ordinary spoon).If you are in need of an operation or other medical examination, notify the doctor prior to taking this medication.Do not stop taking this medication suddenly.Follow the advice of your physician regarding increasing your dosage.Keep it at room temperature, far from heat and moisture. Be aware of the medication you are taking. You must be aware if you are using the medicine improperly or without a prescription.Do not store any empty bottles of opioids. One dose could cause death for someone who is taking the medication in error or incorrectly. Ask your pharmacist for a recycling program for takeback. If there's no take-back plan, dispose of the remaining medicine down the drain.

What happens if I miss the dose?

Because Endocet 2.5/325 is prescribed for pain, you're not likely to skip the dose. Do not miss any doses when it's time to take your next dose. Take only one dose at a time. Do not combine both doses into one pill.

What happens if I overdose?

For medical emergencies, seek immediate attention. Call emergency medical assistance or reach out to the Poison Helpline for advice at 1-800-222-1222. A high dose of this medicine could cause death, particularly for children or any other user of the medication without a prescription. Overdose symptoms may include vomiting, nausea, sweating, severe dizziness, pinpoint pupils, and slow breathing. It could also mean not breathing.The doctor might suggest getting Naloxone (a medication to treat the effects of an addiction to opioids) and carrying it around throughout the day. The person who is caring for you could administer the drug naloxone if your breathing stops or if you do not wake up. The caregiver should still seek medical assistance in an emergency and might need to administer CPR (cardiopulmonary resuscitation) to you as they wait for assistance to arrive.Naloxone can be purchased from pharmacies or your local health department. It is important that everyone who cares for you understands the location where you keep your naloxone and how to make use of it.

What should be avoided?

Beware of driving or operating machinery until you are aware of the way Endocet 2.5/325 can impact your health. Drowsiness or dizziness can lead to accidents, falls, or even severe injuries that require emergency care.Avoid drinking or consuming alcohol. Dangerous side effects or even death could happen.Talk to your doctor or pharmacist prior to using any other medications that contain acetaminophen (sometimes known as APAP). When you take certain medications at the same time, it can result in a death-threatening overdose.

Interaction with other drug

You might experience breathing problems or withdrawal symptoms when you begin or stop taking other medications. Inform your doctor if you are also taking medication, such as an antibiotic or antifungal medication. blood pressure or heart-related medicine, medication for seizures, or medication to treat HIV as well as Hepatitis C.Opioid medicine may interact with other drugs, causing deadly side effects or even death. Be sure your doctor is aware if you take:

  • Cold or allergy medications, asthma bronchodilator or COPD medication, or a diuretic ("water pill");
  • Medicines to treat motion sickness and irritable bowel syndrome medicines for motion sickness, irritable bowel syndrome, and the overactive bladder;
  • Other opioids, such as pain medication and prescription cough medicine;
  • A sedative such as Valium, diazepam, alprazolam, and lorazepam; Xanax, Klonopin, Versed, and more;
  • Medications that induce sleep or reduce your breathing rate—a sleep pill or muscle relaxer, a medicine to treat mental illness
  • Serotonin-related drugs can alter the levels in your body. They can be stimulants or medications for depression, Parkinson's disease, migraine headaches, severe infections, or vomiting and nausea.

This list isn't complete. Other medications could influence Endocet 2.5/325, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. There are not all the interactions mentioned here.



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NDC 60951-712-70, Endocet, 10 mg / 325 mg, side 1 is E 712,