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Generic name: linezolid (oral/injection) [lin-EZ-oh-lid]
Drug class: Oxazolidinone antibiotics

What is Zyvox?

Zyvox can be described as an oxazolidinone antibiotic that fights bacteria within the body. Linezolid additionally acts as an MAO (monoamine oxidase) inhibitor.

Zyvox can treat various kinds of bacterial infections, like pneumonia and skin infections, that do not respond to other antibiotics.Zyvox can also be used to treat conditions that are not covered in this medication guide.


Certain medicines may cause undesirable or harmful effects when used in conjunction with Zyvox. Discuss with your doctor all the other medications you take.Do not take this medication in the event that you've used an MAO inhibitor in the last 14 days, like isocarboxazid, linezolid, Methylene Blue injection, phenelzine, tranylcypromine, and many others.

Certain drugs may interfere with linezolid. Before taking this medication, discuss with your doctor the other medications you are taking. It may be necessary to stop taking certain medications prior to using Zyvox (in certain cases, at least 5 weeks prior to commencing treatment).

While you are receiving treatment with Zyvox, take care not to start or stop taking any other medication unless your physician recommends it. Do not take the medicine if you are resistant to treatment or if you suffer from untreated or uncontrolled hypertension, a carcinoid tumor, adrenal gland tumors, or an overactive thyroid. If you are taking an antidepressant, psychiatric medication, or other medication, contact your physician immediately if you notice symptoms of a serious interaction with a drug, such as confusion, memory issues, being hyperactive (mentally and physically), losing control, muscle spasms, sweating, shivering, diarrhea, or fever.

Similar or related drugs

Amoxicillin, Doxycycline, Ciprofloxacin, Cephalexin, Metronidazole, Azithromycin, and Clindamycin

Before you take this drug

It is not recommended to take Zyvox if you are intolerant of linezolid.Do not take linezolid if you've used an MAO inhibitor within the last 14 days. A potentially dangerous interaction between drugs could happen. MAO inhibitors are isocarboxazid, Methylene Blue injection, phenelzine, the tranylcypromine drug, and many others.

Consult your physician if you are also taking stimulant medicines, opioid medication, herbal remedies, or medicines to treat mental illness, depression such as Parkinson's disease, severe infections, migraines, or to prevent vomiting and nausea. A reaction with linezolid can result in a serious health condition known as serotonin syndrome.

To ensure that Zyvox is suitable for you, inform your doctor if you previously had:

  • High blood pressure;
  • A thyroid disorder
  • A carcinoid tumor;
  • Bone marrow suppression or an immune system that is weak;
  • Renal or liver illness;
  • Pheochromocytoma (adrenal gland tumor);
  • Diabetes;
  • Seizures;
  • If you use a catheter.

Talk to your doctor if you are nursing or expecting.

If you're nursing, inform your doctor if there is vomiting or diarrhea in your nursing infant.Zyvox liquid (oral suspension) is a source of phenylalanine, which can be harmful if you suffer from the condition known as phenylketonuria (PKU).

How to take Zyvox?

Take Zyvox exactly as recommended by your physician. Follow all instructions on your prescription label, and review all medication guides or instructions sheets.Zyvox tablets and oral suspensions are taken either with or without food.

Zyvox injections are given as an injection into the vein. The healthcare provider will provide the first dose and instruct you on how to administer the drug on your own.You should prepare your injection only when you are ready to administer it. Don't use any medicine that has particles. Contact your pharmacist to inquire about the latest medication.

Follow and carefully read any instructions that are included in your medication. Don't use Zyvox if there is a problem understanding all the instructions to use it correctly. Consult your physician or pharmacist for any concerns.

Mix with the suspension for oral use (liquid) by flipping the bottle upside down three to five times. Don't shake. Make use of the syringe for dosing or a dosage measuring device (not the kitchen spoon).You'll need regular medical tests. Your blood pressure and vision could also be monitored regularly.

Take this medication for the prescribed amount of time, even if symptoms do not improve immediately. Inadequate doses could increase your chances of contracting an illness that is not able to be treated with medication. Linezolid is not able to treat a viral disease like the flu or a commonly occurring cold.

All forms of Zyvox must be kept at room temperature, away from heat, moisture, and light. Don't freeze. Get rid of the liquid that has not been used in 21 days.

Do I be concerned if I miss a dose?

Take the medication as quickly as you are able, but take a break from your missed dosage if it's close to the time for the next dose. Don't take two doses in one go.

What will happen if I take excessively?

In case of medical emergencies, get urgent medical attention, or call to get help from the Poison Help Line at 1-800-222-1222.

What should be avoided?

Beware of taking anti-diarrhea medicines without first consulting your doctor. Diarrhea may be an indication of a new infection.

Consuming tyramine when you're taking linezolid could increase your blood pressure to levels that are dangerous. Avoid foods that contain high levels of tyramine. Examples include:

  • Aged cheeses, meats, or aged cheeses;
  • The meats are fermented or pickled and air-dried or smoked;
  • Sauerkraut;
  • Soy sauce;
  • Tap beer (alcoholic and non-alcoholic);
  • Red wine red wine
  • Any cheese, meat, or any other protein-based food item that is not properly stored.

You should be well-versed in the list of foods that you should avoid when you use Zyvox.

Side effects of Zyvox

See a doctor immediately. If you are experiencing symptoms of an allergic reaction, Zyvox (hives or breathing problems and swelling of your throat or face) or an extreme skin reaction (fever and burning eyes, sore throat, or skin pain), the skin is red or purple with peeling and blisters.

See your doctor right away. If you suffer from:

  • Vision issues, color changes,
  • Extreme stomach discomfort; vomiting that is bloody or watery;
  • A seizure;
  • Being anxious, sweating, or shakey (which may be a sign of low blood sugar);
  • Serotonin levels are high within the human body; the feeling of agitation, hallucinations, fever, sweating, shivering, high heart rate, muscle stiffness, losing coordination, twitching, vomiting, and nausea nausea diarrhea;
  • Acidosis lactic Atypical muscle pain or breathing difficulties, stomach pain, vomiting or irregular heartbeats, dizziness, feeling cold, or feeling tired or weak
  • Low blood cells (fever, chills, fatigue, weakness, disorientation, mouth ulcers, skin sores, easy bruising) unusual bleeding, pale skin, feet, and hands being lightheaded or exhausted.

Get medical attention now if you are experiencing symptoms of serotonin syndrome, for example, hallucinations, agitation, sweating, and shivering. You may also experience rapid heart rate, muscle stiffness, or twitching. Also, you may experience loss of coordination, nausea, vomiting, or diarrhea.

Common Zyvox adverse effects could be:

  • Nausea, vomiting, diarrhea;
  • The skin rash;
  • Anemia (low number of red blood cells)
  • Headache, dizziness.

This isn't a complete list of possible side effects, and others could happen. Contact your physician for advice regarding medical effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Certain medications can interact with linezolid and create serotonin syndrome. Make sure that your physician is aware of any other medications you take, such as stimulant medicines, opioid medications, herbal remedies, medications for mental illness, depression, or Parkinson's disease. Headaches, severe infections, or to prevent nausea or vomiting. Consult your physician before making any changes to the way or how often you take your medication.

A variety of drugs interact with linezolid, and some medications should not be used in conjunction with each other. This includes over-the-counter and prescription medications, vitamins, and herbal products. The interactions between these products are not mentioned in this medication guide. Discuss with your physician all the medicines you are currently taking and any medication you begin or stop taking.



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