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Zolinza

Generic Name: Vorinostat [vor-IN-o-stat]

Drug Class: Histone deacetylase inhibitors

What is Zolinza?

Zolinza is a prescription medication for treating skin conditions caused by T-cell lymphoma that are cutaneous.

Zolinza is typically prescribed when other treatments fail or have failed, or when the cutaneous T-cell lymphoma becomes worse or recurs after you've tried other medications.It isn't known whether Zolinza is safe and effective for children.

Warnings

You shouldn't take Zolinza. If you have an allergy to vorinostat or suffer from liver disease that is severe,Do not use Zolinza if you are pregnant. It may harm your unborn baby.It is not recommended to breastfeed while you use Zolinza.

Drink at least 2 liters of fluid every day to avoid becoming dehydrated while taking Zolinza. Inform your doctor if you suffer from severe diarrhea or vomiting while taking treatment.Follow all the instructions on the medicine label and the package. Be sure to inform your healthcare professionals about your medical ailments, allergies, and any medications you take.

Do not open or crush the Zolinza capsule. Take it in whole. The medicine contained within the capsule could be harmful when it is absorbed into your mouth, eyes, nose, or even skin. If this happens, clean your skin using soap and water or wash your eyes with water. Consult your physician or pharmacist about the best way to remove the broken tablet or capsule.

Stop taking Zolinza and contact your doctor immediately if you experience chest pain, a sudden cough, wheezing or sneezing, rapid breathing, or the coughing up of blood and warmth or swelling on both legs. Chills, fever, mouth sores bleeding or bruising easily, tools that are bloody or tarry, vomiting that is severe, or diarrhea.

Before you take this drug

To make sure that Zolinza isn't harmful for you, inform your doctor whether you suffer from:

  • High blood sugar or diabetes;
  • A blood clot;
  • Liver disease;
  • An electrolyte imbalance (such as a low level of magnesium or potassium within your blood) an electrolyte imbalance (such as low levels of potassium or magnesium in your blood)
  • Any allergies.

Vorinostat could harm the unborn baby when either the father or the mother is taking the medicine.

  • If you're female, do not use Zolinza when you are expecting. Utilize effective birth control to avoid the onset of pregnancy while taking this medication and for at least six months following the last dose.
  • If you're male, use effective birth control when your partner is capable of becoming pregnant. Use birth control for a minimum of 3 months following the last dose.
  • Inform your doctor immediately. If you become pregnant when both the mother and father are taking Zolinza.

Do not breastfeed when taking this medicine or for at least a week after the last dose.

Similar/related drugs

Bexarotene, methoxsalen, romidepsin, interferon gamma-1b, and vorinostat

How do I take Zolinza?

Use Zolinza as directed by your physician. Follow the instructions on the label of your prescription and study all the medication instructions or sheets. The doctor might modify your dose.Drink in with food. Take at least 2 liters of fluid every day to prevent becoming dehydrated.

Take the capsule in its entirety and don't chew or break it. You can also crack it. The medication contained within the capsule may be dangerous when it is absorbed into your eyes or skin. If this happens, you should wash your skin with water and soap, or wash your eyes with water, and then contact your doctor.

Inform your doctor if you are having difficulty taking the capsule in its entirety.The blood sugar levels of your patients will need to be monitored regularly, and you might require additional tests to determine your blood sugar.

Consult your doctor if you are suffering from diarrhea, especially if you have diabetes and are unable to consume food or drink normally.There are other medicines to prevent nausea, vomiting, or diarrhea. Use these medications for the duration your doctor prescribes.Place it in a cool, dry place free of heat and moisture.

Details on dosage

Usual Adult Dose for Cutaneous T-cell Lymphoma:

400 mg once orally per day. If the patient is not tolerant to treatment, the dose can be reduced to 300 mg orally every day; the dosage could be reduced further to 300 mg a day for five consecutive days every week, if necessary.
It is recommended to take this drug in conjunction with food.
Swallow capsules whole; don't open or crush them.
The treatment can be continued until there isn't any evidence of disease progression or unacceptable toxic effects.
Use: In the treatment of cutaneous manifestations among patients suffering from cutaneous T-cell lymphoma that is an ongoing, progressive, or recurrent disease or after 2 treatments

What happens if I miss a dose?

Do not take the medicine for as long as you can. But, don't do any missed doses when you are close to the date of your next dose. Don't take two doses at a time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

Avoid this

Avoid being overheated or dehydrated during workouts and in the heat of summer.

Side effects of Zolinza

Get immediate medical attention. If you are experiencing symptoms that indicate an allergy reaction with Zolinza, such as hives, difficulty breathing, or swelling of your lips, face, and tongue,

Contact your doctor immediately if you are suffering from:

  • Symptoms of dehydration symptoms of dehydration, such as dizziness or drowsiness. Feeling extremely thirsty or hot, having difficulty urinating, sweaty, and with dried skin;
  • Blood sugar levels are high, increasing thirst and more frequent urination; the mouth is dry; and there's a fruity smell.
  • Lower platelets, also known as red blood cells pale skin, easy bruising, unusual bleeding, or dark or red spots in your skin. Fatigue and lightheadedness You may also feel cold feet and hands.
  • Symptoms for a blood clot inside the lung: chest pain, rapid heartbeats, shortness of breath, sweating, coughing up blood,
  • Indications for a blood clot within your leg (pain, swelling, redness, or warmth in both legs).

Common Zolinza side effects may include:

  • Nausea, nausea, vomiting, lack of appetite
  • Diarrhea, constipation;
  • Weight loss;
  • Swelling in your lower legs;
  • Dry mouth;
  • Chills, fever, headache, muscle pains;
  • Symptoms like nasal stuffiness, sneezing, and coughing.
  • Dizziness, tiredness;
  • Itching or itching, hair loss,
  • A change in taste.

This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician for advice regarding medical effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Discuss with your doctor all other medicines you take, particularly:

  • Valproic acid;
  • A blood thinner (warfarin, coumadin, or Jantoven).

This list isn't complete. Other drugs can interfere with vorinostat. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Some interactions with drugs are not listed here. Are included here.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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