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Generic Name: Daclizumab [dah-KLIH-zyoo-mab]
Drug Class: Interleukin inhibitors

What is Zinbryta?

Zinbryta is a monoclonal antigen that affects the functions of the immune system. Monoclonal antibodies are specific and destroy cells within the body. This can help protect healthy cells from harm.Zinbryta helps treat relapsing types of MS.Zinbryta is typically prescribed in situations where other medications have not proven effective.

Zinbryta can only be purchased from a pharmacy that is certified under an exclusive program. You must be enrolled in the program and know the potential risks and benefits of using this medication.


It is not recommended to use Zinbryta in the case of liver disease or autoimmune liver disease.Zinbryta could cause severe or fatal liver issues. Call your doctor immediately if you notice symptoms like nausea, vomiting, upper stomach pain, fatigue, or a loss of appetite. dark urine as well as jaundice (yellowing of the eyes or skin).

It is recommended to have frequent blood tests to assess the liver's function throughout treatment as well as after stopping taking this medicine. The next dose may be delayed depending on the outcome of your tests.

Zinbryta can also increase the chance of contracting certain diseases or issues with the immune system. Contact your doctor if you notice a rash on your skin, a fever, swollen glands and stomach pains, diarrhea and bloody stool, or any other unusual or new signs.

Before you take this drug

It is not recommended to use Zinbryta if you have an allergy to daclizumab or have had any of the following:

  • Liver disease
  • An autoimmune history of hepatitis.

To ensure that zinbryta is appropriate for you, consult your doctor if you suffer from:

  • Active infection, such as tuberculosis
  • Liver issues, such as liver problems, such as hepatitis b or c;
  • Skin issues such as skin problems like eczema, psoriasis,
  • Depression or depression
  • If you are due to get any vaccinations.

It is unclear if Zinbryta can harm an unborn baby. Inform your doctor if you are expecting or planning to be pregnant.

It isn't known if daclizumab is absorbed into breast milk or if it can affect breastfeeding babies. Talk to your doctor if you are nursing a child.Zinbryta is not a drug that has been approved to be used by anyone younger than 18 years old.

How to take Zinbryta?

Utilize Zinbryta exactly as recommended for you. Follow the directions on the prescription label. Don't use this medication in smaller or larger quantities or for longer than the recommended time.

Zinbryta is injected beneath the skin. It is possible to be taught how to administer injections at home. Don't give yourself this medication if you do not know how to administer the injection properly and get rid of needles that are no longer needed and the syringes.

Zinbryta is generally administered once a month. Be sure to follow the dosing instructions of your doctor with care.The medication includes a medication guide and a wallet card that list the symptoms of immune system or liver issues. Take note of this information and keep this wallet card with you at all times to be aware of the symptoms to look for.

This medicine could cause fatal or serious liver issues. You'll need blood tests to determine the liver's functioning each month while taking Zinbryta. Your next dose could be delayed based on the test results.You'll also require frequent tests of your liver's function for six months following the time you stopped taking this medication.

Place the original container in the refrigerator. Keep away from light and heat. Avoid freezing Zinbryta, and don't take the medicine in the event that it freezes.

Before injecting the dose, take a vial of the medicine out of the refrigerator and let it reach room temperature for about 30 minutes. Don't heat the medication using a microwave or hot water. Don't put the vial back in the refrigerator after having it at room temperature.

Don't use Zinbryta when it appears to be cloudy or contains particles within it. Consult your pharmacist about the latest medication.Zinbryta can be kept in the original container at room temperature for up to 30 days. When the medication has been brought to room temperature, do not place it in the refrigerator.

Every single-use syringe, syringe, or injection pen is designed for only one use. Dispose of it after one usage, regardless of whether there is any remaining medicine.Make use of the disposable needle and syringe only once. Make sure you follow any state or local regulations regarding the disposal of used needles and syringes. Make sure you use a puncture-proof "sharps" disposal container (ask your pharmacist where you can get one and what to do with the container). Make sure this container is away from animals and children.

Details on dosage

Usual Adult Dose for Multiple Sclerosis:

Ages 17 and over:
150 mcg subcutaneously, once a month
The most common injection sites include the abdomen, thigh, and lower back of the upper arm.
If a dose is missed within two weeks of the scheduled dose, the dose should be administered immediately, and the month-long dosing schedule must be reestablished.
If a dose is missed and is more than two weeks away from the scheduled dose, the missed dose should be skipped. The original month-long dosing schedule must be reestablished.
Only one dose can be administered at any one time.
Use: To treat adults suffering from multiple sclerosis that relapses (MS) who've experienced an ineffective response to two or more medications.

What happens if I miss a dose?

Take the dose you missed as soon as you can remember. When you're over two weeks behind, you should skip your missed dosage. Don't take any additional medicine to make up for the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

Avoid this

Do not get a "live" vaccine while using Zinbryta and for a minimum of 4 months after the last dose. Live vaccinations can include measles, rubella, and mumps (MMR), as well as polio, typhoid, rotavirus fever, varicella (chickenpox), zoster (shingles), and the nasal influenza (influenza) vaccination.

Side effects of Zinbryta

See a doctor immediately. If you experience symptoms that indicate that you are experiencing an allergic reaction to Zinbryta (hives, difficulty breathing, swelling of your throat or face) or a severe skin reaction (fever and sore throat, burning in your eyes, pain in your skin, as well as a red or purple itching that can cause peeling and blistering),

Contact your doctor immediately. If you suffer from:

  • Extreme stomach discomfort; diarrhea that is bloody or watery
  • Skin that is pale or yellowed in a state of confusion or weakness
  • Easily bleeding or bruising (nose, mouth, vagina, or rectum);
  • Burning or pain after you urinate;
  • Breathlessness;
  • Liver issues: loss of appetite, stomach pain, fatigue, black stools, dark urine, and jaundice (yellowing of the eyes or skin);
  • Any kind of disease—an abrupt feeling of weakness or illness such as fever, chills, or swollen glands. Mouth sores, difficulty swallowing, symptoms of the flu or cold,
  • Signs of depression such as tears, sadness, fatigue, difficulty controlling your attention, anger, feeling depressed or angry, or thinking about suicide or harming yourself.

The treatment you receive may be delayed if you suffer from some adverse effects.

Common zinbryta adverse effects could include:

  • Cold symptoms (stuffy nose, nasal pain, sinusitis, sore throat);
  • Influenza symptoms (fever and body aches, swelling of the glands, sore throat)
  • Cough, chest tightness
  • Mouth discomfort;
  • Depression;
  • Itching or rash;
  • Dry, flaky skin,
  • Unusual liver function tests.

This is not a comprehensive list of all the side effects. Other side effects could occur. Contact your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Daclizumab could cause liver damage. This effect is enhanced when you are also taking various other medications, such as the following: antibiotics, tuberculosis medication, antifungal medicine, birth control pills, hormonal replacement therapies, some antidepressants, blood or heart pressure medications, as well as a "statin" cholesterol medication, seizure medication, and certain arthritis or pain medications (including acetaminophen, Tylenol, Advil, Motrin, and Aleve).

Many medications can interact in some way with daclizumab.It includes over-the-counter and prescription medications, as well as the herbal and vitamins. There are many possible interactions that are covered in this information. Tell your doctor about all the medications you are currently taking and any medications you begin or stop taking.