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Generic Name: Clindamycin and tretinoin (topical) [klin-da-mye-sin-and-tret-i-noyn-top-i-kal]
The Brand Names are Veltin and Ziana.
Drug Class: Topical acne agents

What is Ziana?

Ziana can be described as a gel that contains a combination of clindamycin and tretinoin. Clindamycin can be described as an antibiotic. It fights bacteria within the body.

Tretinoin is a type that contains vitamin A. It decreases the amount of oil produced by the glands that produce oil in your skin. It also helps your skin renew itself faster.Ziana can be used for treating severe acne nodules in children and adults who are 12 years old.Ziana can also be used for reasons not listed in this medication guide.


Do not get Ziana within your mouth, eyes, or nose (or in the creases on your nose) or on your lips. If it gets into one of these places, clean it off with water. Don't apply Ziana to sunburned, windburned, chapped, irritated, or damaged skin.

This medication is recommended if you suffer from Crohn's disease, ulcerative colitis, inflammation of the intestinal tract (also known as enteritis), or severe diarrhea due to antibiotics.It is not recommended to use Ziana when you are taking an additional antibiotic known as erythromycin or if you are taking other skin care products that contain erythromycin.

While Ziana can be applied directly to the skin, it is possible that your body will absorb enough clindamycin to cause severe side effects.Avoid exposure to artificial UV radiation (from sunlamps as well as tanning beds). Ziana may cause your skin to become vulnerable to light, and sunburn could result. Make sure you apply sunblock (minimum SPF 15) and wear a protective outfit if you are in the sunlight.

The skin of your child may become more sensitive to extreme weather conditions like wind and cold. Make sure you protect your skin by wearing clothes and applying moisturizing lotion or cream whenever you need it.

Before you take this drug

Even though Ziana applies to the skin, the body could absorb enough clindamycin to alter the medical conditions you may be suffering from.

It is not recommended to use this medication if you have an allergy to tretinoin or clindamycin or if you suffer from:

  • Inflammation of the intestinal tract (also known as enteritis);
  • Colitis, Crohn's disease, and ulcerative
  • If you've ever experienced extreme diarrhea that was caused by antibiotics,

You shouldn't take Ziana when you are taking an additional antibiotic known as erythromycin or are using other skin care products that contain erythromycin.

To ensure that Ziana is suitable for you, inform your doctor if you suffer from:

  • Any allergies
  • An underlying digestive or stomach disorder.

FDA pregnancy category C. It isn't known whether Ziana can harm an unborn child. Inform your doctor if you are expecting or planning to get pregnant while taking Ziana.

It is unclear if the topical clindamycin and tretinoin pass into breast milk or if they can harm the nursing infant.It is not advised to breastfeed while taking this medication.

This medicine is not recommended for children who are less than 12 years old.

How to take Ziana?

Utilize Ziana exactly according to the prescription your doctor has given you. Follow the directions on the prescription label. Don't use this medication in greater or lesser quantities or for longer periods than the recommended time. Applying more medicine or using it more frequently than prescribed does not help it perform any better and can cause more adverse effects.

Wash your hands thoroughly prior to and after applying the medication.Cleanse your face with mild soap or cleanser, and then dry your skin using a clean towel.Only apply a tiny portion of Ziana. Apply it to your entire face each night before bed.

Wash your face at least three times per day when using this drug. Scrubbing or washing your face more frequently after washing it can cause your acne to get more severe.

Do not get Ziana in your mouth, eyes, or nose (or within the creases of your nose) or on your lips. If it does infiltrate one of these places, rinse with water. Don't apply the medicine to sunburned, windburned, chapped, dry, irritated, or damaged skin.

Make sure to use Ziana for the prescribed time period, even if you believe it's not working. Consult your doctor if the itchy skin becomes very severe or the acne does not improve after a few weeks of taking this medication.If you require surgery, inform the surgeon in advance that you're using Ziana.Storage at room temperature, free of heat, moisture, and light. Don't freeze.

What happens if I miss the dose?

Utilize the medicine when you can remember the dose that you missed. If it's almost time to take your next dose, do not take the missed dose, and then take the medicine at the next scheduled time. Do not take extra medicine to replace the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

Avoid this

Do not wash treated skin or apply any other products for at least one hour after applying this product.Avoid other medications for the areas you are treating with Ziana unless your doctor advises you to. Avoid using products for your skin that may cause irritation, like harsh shampoos, soaps, or cleansing products for your skin, hair coloring chemicals, hair removers and waxes, or other skin care products made of alcohol, spices, lime, or astringents.

Diarrhea can be caused by antibiotics and could be an indication of an infection that has just started. If you experience diarrhea that is bloody or watery and bloody, stop taking this medication and consult your physician. Avoid using anti-diarrhea medicines unless you are advised to do so by your physician.

Ziana could cause you to burn more quickly. Make sure you apply the sunscreen (SPF 30 or greater) in the morning and when needed. Avoid exposure to the sun and tanning beds.Your child's skin may have a higher sensitivity to extreme weather conditions such as wind and cold. Cover your skin with protective clothing and apply lotion or moisturizing cream if necessary.

Side effects of Ziana

Get immediate medical attention. If you experience any of the symptoms or warning signs of an allergic reaction, Ziana symptoms include hives, difficulty breathing, or swelling of your lips, face, and throat.

Stop taking this medication and contact your doctor immediately if you suffer from:

  • Severe redness, burning, itching, or scaling of skin areas treated with chemical peels and
  • Diarrhea that is either watery or bloody.

Common ziana side effects can include:

  • Minor itching, dryness, or peeling
  • Mild skin redness,
  • Itching from itching of the skin treated.

This is not a comprehensive list of all the side effects. Other side effects could occur. Contact your physician to seek medical advice on adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

It's unlikely that other medications you consume orally can affect topically applied clindamycin and tretinoin. However, many drugs interact with each other. Inform your health care professionals about any medications you take, such as prescription and over-the-counter medications, vitamins, and herbs.