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Name of Generic: Acetaminophen, butalbital, caffeine, and caffeine bue-TAL-bi-tal-si-tal, a-SEET, and-KAF-een [a-SEET-a-MIN-ohfen, bue TAL
The Brand Names are Esgic, Fioricet, and Zebutal.
Drug Class: Analgesic combinations

What is Zebutal?

Acetaminophen can be used as an anti-inflammatory and fever-reducing agent.Butalbital is part of a family of drugs known as barbiturates. It eases muscle tension in the event of a tension-related headache.Caffeine can be described as a stimulant for the central nervous system. It eases muscle contractions in blood vessels, thereby increasing blood flow.

Zebutal is a combination medication that is used to treat headache tension, which results from muscle contractions.Zebutal is also employed for other purposes that are not covered in this guideline.

Side effects of Zebutal

Contact a medical professional immediately in the event that you exhibit symptoms that indicate an allergy, such as hives, breathing difficulties, and swelling of your lips, face, and tongue.

In rare instances, acetaminophen can cause severe skin reactions that could be fatal. This could occur regardless of whether you've previously used acetaminophen without experiencing any reactions. Take a break from Zebutal and consult your physician immediately if you experience the appearance of a skin rash or redness that spreads and causes blisters or flaking. If you have this kind of reaction, then you shouldn't use any medication that contains acetaminophen.

This medicine could trigger severe adverse effects. Take this medicine off and consult your physician immediately if you suffer from:

  • Confusion, a seizure;
  • Breathlessness;
  • An euphoric feeling, similar to feeling like you're about to pass out
  • Nausea, nausea, stomach discomfort, irritation, weight loss, black stools, dark urine, and jaundice (yellowing of the eyes or skin).

Common adverse effects of zebutal can include:

  • Drowsiness, dizziness;
  • Feeling lightheaded;
  • Nausea, vomiting, and stomach pain;
  • Drunk feeling;

This is not an exhaustive listing of all possible adverse impacts, as other things may occur. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Avoid using this medication. If you've taken an MAO inhibitor within the last 14 days. A risky drug interaction may happen. MAO inhibitors comprise isocarboxazid linezolid and methylene blue injection Phenelzine and tranylcypromine.

Don't take more of this medication than is advised. A high dose of acetaminophen could damage your liver and result in death. Call your doctor immediately if you notice nausea or pain in your stomach area. Itching and loss of appetite, dark stools, clay-colored  urine, and jaundice (yellowing of the eyes or skin).

In rare instances, acetaminophen could cause a serious skin reaction. Do not take this medication and contact your physician right away in the event of the appearance of a rash or skin redness that spreads, causing blisters as well as peeling.

Before you take this drug

Do not take Zebutal if you've previously used an MAO inhibitor within the last 14 days. A potentially dangerous interaction with a drug may occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You shouldn't take Zebutal if you have an allergy to it, suffer from porphyria, or have recently consumed alcohol, sedatives, tranquilisers, or any other opiates.

Speak to your doctor if you are ever diagnosed with:

  • Liver diseases, cirrhosis, the background of alcoholism or addiction to drugs, or if you consume more than 3 alcoholic drinks every day;
  • Kidney disease;
  • Stomach ulcer or bleeding
  • An occurrence of a skin rash due to any medication
  • An underlying suicidal ideation or mental illness.

It is unclear if this medication can harm an unborn child. If you take butalbital when you are pregnant, your baby may become dependent on the drug. This can cause withdrawal symptoms that can be life-threatening for the newborn after it's born. Children who are dependent on habit-forming drugs could require medical treatment for a period of time. Inform your doctor if you are expecting or planning to be pregnant.

This medication can be absorbed into the milk of a nursing baby and cause harm to the infant. Inform your doctor if you are breastfeeding a child.Not permitted for use by anyone under twelve years of age.

How to take Zebutal?

Follow the directions on the prescription label. Don't take more medicine than you are advised to. An overdose can damage your liver or cause death. Inform your doctor when the medication seems to be unable to work as well in relieving discomfort.

Butalbital can be addictive. Do not share this medication with anyone else, particularly those who have a history of substance abuse or dependency. Keep the medication in a location where other people aren't able to access it. The act of selling or giving away this medicine is against the law.Place it in a cool, dry place far from heat and moisture.

Make a note of the quantity of medicine you take in each bottle. Butalbital is a substance that is misused, and you must be aware of any person who is taking your medication improperly, with or without a prescription.

What happens if I miss the dose?

Because zebutal is only used in times of need, it is possible that you are not on a schedule for doses. If you're following a regimen, take the missed dose as quickly as you can remember. Do not take any missed doses if it's close to the time of the next dose scheduled. Do not take extra medicine to replace the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help line at 1-800-222-1222. A high dose of zebutal could result in death.

The initial signs of an acetaminophen overdose are loss of appetite, nausea, stomach pain, vomiting, sweating, and weakness or confusion. Other symptoms could include discomfort in your stomach as well as dark urine and discoloration of your skin or the whites of your eyes.The symptoms of an overdose can consist of insomnia as well as anxiety, tremors, diarrhea, irregular heartbeats, seizures (convulsions), and falling asleep.

What should be avoided?

The medication could produce side effects that can affect your reactions or thinking. Be aware of this if you are driving or engaging in any activity that requires you to stay alert as well as awake.Do not drink alcohol. It could increase the chances of suffering liver problems when taking acetaminophen.

Consult a physician or pharmacist prior to using or taking any illness, cold, allergy pain, sleep, or cold medication. Acetaminophen (sometimes abbreviated as APAP) is found in a variety of combination medications. Combining certain medicines could cause excessive amounts of acetaminophen, which could cause an overdose that is fatal. Check the label to determine if the medicine includes acetaminophen or APAP.

When you're using this medicine, try not to use weight loss pills, caffeine tablets, or any other stimulants (such as ADHD medication) without your doctor's guidance.

Interaction with other drugs

Utilizing Zebutal together with other medicines that cause you to sleep or slow your breathing could result in life-threatening or dangerous negative side effects. Ask your doctor prior to taking Zebutal together with a sleeping medication, opioid pain medication, muscle relaxer, or medication to treat anxiety, depression, or seizures.

Other drugs can interact with Zebutal, such as prescription and non-prescription medications, vitamins, and herbal products. Discuss with your doctor all other medicines you take



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