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Generical name: selinexor Selinexor SEL-iNEX-or [SEL-i-NEX-
Classification of drugs: miscellaneous antineoplastics

What is Xpovio?

Xpovio is used in conjunction with bortezomib or dexamethasone to treat multiple myeloma in adults. It is used to treat:

  • When combined with the drugs in combination with dexamethasone and bortezomib to treat patients with multiple myeloma who have had at least one treatment prior to the disease.
  • When used in conjunction with dexamethasone, to treat adults suffering from multimyeloma (mm) who have returned (relapsed) or have not responded to prior treatment (refractory) and
    • Who have had at least 4 treatments previously and who have had at least 4 previous therapies
    • The disease of patients who were not able to respond (refractory) to treatment with at least two proteasome inhibitors and at least two immunomodulatory agents, as well as an anti-cd38 monoclonal antibody medication.

The drug is also utilised for adults to treat certain kinds of diffuse B-cell lymphoma that have recurred (relapsed) or didn't respond to prior treatments (refractory) and have had at least two previous treatments.

Xpovio is approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, certain patients responded to the medicine. However, further research is required.


Xpovio influences the immune system. You could contract infections more often, including deadly or serious infections. Call your doctor if you are suffering from a fever, chills, flu-like symptoms, a cold, mouth ulcers, a cough, or breathing problems.

Xpovio may also result in low blood platelet counts. Inform your doctor immediately in the event of unusual bruising or bleeding.

Before you take this drug

To be sure Xpovio is suitable for you, inform your doctor that you have:

  • Cataracts;
  • Bleeding issues
  • An active or recent infection.

You might need to undergo an unfavourable pregnancy test prior to commencing this treatment.Both women and men who are taking this medication should utilise effective birth control to stop pregnancy. Selinexor can harm unborn babies if the father or mother is taking the medication.

Continue using birth control for a minimum of one week following your last dose. Contact your doctor right away in the event of a pregnancy occurring when both the mother and father are taking Xpovio.The medicine can impact fertility (ability to have kids) for both men and women. But it is crucial to use birth control in order to stop pregnancy, as selinexor could affect the unborn baby.Don't breastfeed while taking this medication or for at least a week following the last dose.Xpovio is not a product that is approved to be used by anyone younger than 18 years of age.

How to take Xpovio?

Take Xpovio exactly as directed by your physician. The doctor will run tests to ensure that this medication is the best treatment for you.Follow the directions on your prescription label and review all medication guides and instruction sheets. Your doctor may modify your dose.Xpovio is usually taken on certain days and is usually taken every week, either once or twice. Follow the doctor's directions attentively about the best time and method to take Xpovio with dexamethasone, bortezomib, or dexa.

The doctor you consult will decide the length of time you will be treated with this medication.Take Xpovio with the full amount of water. Suck the tablet completely and don't crush, chew, or tear it.If you have a stomach ache within a few minutes of taking Xpovio, don't take a second dose. The next dose should be taken as soon as you are scheduled to do so.

You might also be prescribed additional medications to treat vomiting, nausea, or infections. Take these medications for the duration your physician prescribes.There is a chance that you will contract infections more frequently, even fatal or severe infections. You'll require frequent medical tests. It is possible to require a transfusion in the event that the platelets in your blood get low.

The sodium levels in your blood must be evaluated. If they are low enough, your doctor might recommend tablets of salt or intravenous (IV) fluids to help keep you from becoming dehydrated.Get plenty of water to avoid dehydration. Also, consume enough calories to avoid losing weight.Selinexor may affect your appetite or capacity to consume food. The patient will be measured prior to and during the treatment in order to ensure that you don't lose weight when taking Xpovio.Keep the tablets at room temperature, free of heat and moisture. Store each tablet in the package until ready for your next dose.

Details on dosage

Usual Adult Dose for Multiple Myeloma:

100 mg orally every week on the first day of every week, until progression of the disease or unacceptable toxicity when combined with the drug bortezomib 1.3 mg/m2 subcutaneously every week on the first day of each week for four weeks, followed by one week off, and dexamethasone 20 mg taken orally twice a week on days 1 and 2 of every week.
80 mg taken orally on days 1 and 3 each week, until the progression of disease or unacceptable toxicity is encountered with dexamethasone; 20 mg orally in every dose on days 1 and 3 each week.
For additional information about the administration of bortezomib or dexamethasone, consult its prescription information.
It is recommended to consider IV hydration for patients who are at high risk for dehydration.
Provide prophylactic concurrent treatment with a 5-HT3 antagonist or other anti-nausea drugs before and during treatment.
In combination with bortezomib or dexamethasone in patients with multiple myeloma who have had at least one prior therapy.
In conjunction with dexamethasone, patients with relapsed or resistant multiple myeloma who have had at least four prior treatments and are refractory to at least two inhibitors of the proteasome and at least two immunomodulatory agents, as well as an antibody monoclonal to CD38,

Usual Adult Dose for Lymphoma:

60 mg orally every day one and three of every week, until the progression of disease or unacceptably toxic
It is recommended to consider IV hydration for those at risk of becoming dehydrated.
Prophylactic treatment for concomitant use using a 5HT3 antagonist and/or other anti-nausea medications before and during treatment
Use: To treat relapsed or resistant diffuse large B-cell lymphoma (DLBCL) that is not defined, which includes DLBCL that results from follicular lymphoma, in the absence of at least two treatments with systemic therapy.

What happens if I miss a dose?

Don't miss the dose you missed, and take your next dose at your regular time. Don't take two doses at the same time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided Xpovio?

Avoid driving or engaging in hazardous activities until you are aware of the effects this medicine has on your body. Your reaction could be affected.

Side effects of Xpovio

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate you are experiencing an allergic reaction. Xpovio: hives, breathing problems, and swelling of your lips, face, or tongue.

Xpovio could result in fatal or serious adverse effects. Certain side effects may not manifest until after you have taken this medication for a period of time, such as weeks or days.

Contact your doctor immediately for:

  • Blurred vision blurred vision, tunnel vision, eye pain, or seeing halos of light sources;
  • Extreme, continuous nausea, vomiting, or nausea;
  • Lack of appetite, which prevents you from eating and leads to the loss of weight;
  • Confused, dizziness, fainting, and changes in mental state;
  • Signs of sepsis, such as chills or fever, extreme drowsiness, rapid breathing, rapid heartbeats, or feeling sickly;
  • Indications of signs and symptoms of infection: chills, fever, and flu symptoms; a cough that is accompanied by mucus, throat, and mouth ulcers; a tired sensation; pain or a tingling skin rash on one part of your body;
  • Low sodium levels low sodium level, headache, and slurred speech. Severe weakness, vomiting, loss of coordination, and feeling unstable.

The treatments you are receiving might be delayed or stopped if you experience specific adverse reactions.

Common Xpovio side effects can include:

  • Dual vision and blurry vision sensitive to light or glare.
  • Tiredness;
  • Tingling, numbness, and burning or numbness in your feet or hands;
  • Bleeding, bruising, or anaemia;
  • Higher blood sugar levels
  • Illness, fever, or symptoms of the flu;
  • Shifts in sodium and mineral levels;
  • An abnormal kidney or liver function test;
  • Nausea, vomiting, and a loss of appetite
  • Diarrhoea, constipation;
  • Weight loss;

This isn't a complete list of possible side effects, and others could happen. Contact your doctor for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications may interfere with selinexor. These include prescription as well as over-the counter medications, vitamins and natural products. Inform your physician about any other medications you take.




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