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Name of the Generic: Nabumetone.
Names of Brands: Relafen, Relafen DS.
Dosage Format: Oral tablet (1000 mg, 500 mg, 500 mg, 500 mg, 750 mg).
Class of Drug: Nonsteroidal anti-inflammatory drugs.

What is Nabumetone?

Nabumetone is an anti-inflammatory nonsteroidal drug (NSAID). Nabumetone is a drug that works by cutting down hormones that cause inflammation and pain within the body. Nabumetone is used to alleviate some of the signs and symptoms associated with rheumatoid arthritis and osteoarthritis. Nabumetone can also be used for reasons not mentioned in this guideline.

Side effects of Nabumetone

See a doctor immediately when you are experiencing symptoms warning signs of an allergic reaction (hives and sneezing, stuffy noses, wheezing or difficulty breathing, swelling on your throat or face) or a severe reaction to your skin (fever and sore throat, eye burning, irritation, and red or purple skin eruption with peeling and blisters). Take immediate medical care in the event that you exhibit symptoms of an attack on your heart or stroke. chest pain spreading into your shoulder or jaw, suddenly feeling numb or weak in one area of your body, speech slurred, feeling tired

Nabumetone could cause serious adverse side effects. Stop using the drug and consult your physician immediately in the event of:

  • Breathlessness (even when exerting only a little).
  • Weight gain, swelling, or rapid weight gain.
  • The very first indication of an itchy rash, no matter how slight.
  • Symptoms of stomach bleeding: bloody or black stools, the spouting of blood, or vomiting that appears like coffee grounds.
  • Liver problems: nausea and stomach pains in the upper part of the stomach, itching, fatigue, flu-like symptoms, and loss of appetite. the dark color of urine; stools that are clay-colored; jaundice (yellowing of the eyes or skin).
  • Kidney problems: no or little urination, hard or painful urine, swelling of your ankles or feet, being tired or sluggish.
  • Low red blood cells (anemia): pale skin, fatigue, feeling lightheaded or exhausted, cold hands and feet.

Common negative side effects of nabumetone include:

  • Stomach pain, indigestion, nausea.
  • Diarrhea, constipation, gas.
  • Swelling of your feet and hands.
  • Headache, dizziness.
  • The skin, an itchy rash.
  • Your ears are ringing.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Nabumetone could increase the chance of death from coronary heart attacks as well as strokes. Don't use nabumetone prior to or after the heart bypass surgery (coronary bypass graft of the artery, also known as CABG). Nabumetone can cause diarrhea or stomach bleeding, which could be fatal.

Before you take this drug.

Nabumetone may increase the chances of suffering fatal heart attacks or strokes, even if you do not possess any risks. Don't take this medication immediately prior to or following the procedure for heart bypass (coronary bypass grafts for the artery, or CABG). Nabumetone can also trigger diarrhea or stomach bleeding, which can lead to fatal bleeding. These issues can happen at any time while taking nabumetone. This is especially true for older people. Nabumetone should not be used when you have an allergy to it, have had one asthma attack, or have had a severe allergic reaction following the use of aspirin or an NSAID.

Speak to your doctor if you are ever diagnosed with:

  • Heart diseases, high blood pressure, high cholesterol, diabetes, and smoking.
  • A coronary heart attack, stroke, or blood clot.
  • Stomach ulcers or bleeding.
  • Asthma.
  • kidney disease or liver failure.
  • Fluid retention.

If you are expecting and you are taking Nabumetone unless your physician tells you otherwise, Taking an NSAID in the final 20 weeks before the birth could cause kidney or heart problems for the unborn baby and possibly complications related to the pregnancy. It is not recommended to use this medicine while breastfeeding. Nabumetone has not been approved to be used by anyone younger than 18 years of age.

How to take Nabumetone?

Follow the instructions on the prescription label and go through all the medication instructions. The doctor could alter your dosage. Choose the dose that works for treating your illness. Nabumetone is a drug that can be taken with or without food. If you are taking nabumetone for a long time, it is possible that you will require frequent medical tests. Keep the bottle at room temperature, far from heat and moisture. Make sure the bottle is tightly sealed when not being used.

Details on dosage

Usual Adult Dose for Osteoarthritis:

Initial dose: 1000 mg taken orally at least once per day.
Maintenance dosage: 1500–2000 mg daily orally in 2 or 1 divided doses.
Maximum dose: 2000 mg/day.
Comments: Patients weighing less than 50 kilograms are less likely to require doses that go beyond 1000 mg.
Once the response to therapy has been established, the dose and frequency must be adjusted to a minimum effective dose and a shorter duration suitable to meet the specific patient's needs.
Use: To ease the pain of symptoms and signs of osteoarthritis and rheumatoid arthritis.

Usual Adult Dose for Rheumatoid Arthritis:

Initial dosage: 1000 mg orally every day, once
Maintenance dosage: 1500–2000 mg per day orally, in 2 or 3 divided doses
Maximum dose: 2000 mg/day
Comments: Patients who weigh less than 50kg are less likely to need dosages greater than 1000 mg.
When the patient's response to treatment is identified, frequency and dose will be adjusted according to the most effective dose and the most minimal timeframe for the patient's individual treatment objectives.
Use: For the alleviation of the symptoms and signs of rheumatoid arthritis and osteoarthritis.

What happens if I miss a dose?

Do not take the medicine for as long as you are able, but do not take any missed doses if you are close to the time of the next dose. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Beware of drinking alcohol. This can increase the chance of bleeding from your stomach. Consult a physician or pharmacist before taking other medicines to treat swelling, pain, fever, or other symptoms of a cold or flu. They could contain ingredients similar to nabumetone (such as aspirin, ibuprofen, ketoprofen, or naproxen). Nabumetone can cause skin to burn more quickly. Avoid tanning beds and sunlight. Protect yourself with protective clothes and apply sunblock (SPF 30 or more) while you're outdoors.

 Interaction with other drugs

Consult your physician before taking nabumetone when you are on any antidepressant. Taking certain antidepressants together with an NSAID could cause bleeding or bruises.

Inform your doctor about all other medicines you take, particularly:

  • Lithium.
  • Methotrexate.
  • A bleeding thinner (Warfarin, Coumadin, Jantoven).
  • Heart or blood pressure medications that include diuretics, such as a "water pill";.
  • Steroid medicine (such as prednisone).

This list isn't complete. Other medications may interact with the nabumetone effect, including prescription and over-the-counter medicines, vitamins, and herbal products. There are many possible interactions between drugs. are included here.



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