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Xigduo XR

Generic name: dapagliflozin and metformin [DAP-a-gli-FLOE-zin-and-met-FOR-min]
The class of drug: antidiabetic combinations

What is Xigduo XR?

Xigduo extended-release tablets include a mix of dapagliflozin and metformin. Dapagliflozin as well as metformin can be described as both oral diabetes medications that aid in controlling your blood sugar. Dapagliflozin helps the kidneys eliminate glucose from the bloodstream. Metformin reduces the production of glucose in the liver and allows your intestines to take in less glucose.Xigduo It is combined with exercise and diet to help improve blood sugar control for adult patients with type 2 diabetes mellitus.Xigduo is not intended to treat type 1 diabetes.

Xigduo also works to decrease the likelihood of having to go to the hospital due to heart failure among adults suffering from type 2 diabetes who also suffer from heart disease.Xigduo is also used to lower the chance of a worsening of kidney diseases and deaths as a result of heart issues, as well as the necessity of being in hospitals for failing hearts among adults who suffer from type 2 diabetes and chronic kidney disease.


Do not take XigduoXR if you suffer from severe kidney disease or diabetic ketoacidosis (call your physician to seek treatment).

If you are required to undergo any type of x-ray or CT scan that uses an injection of dye into the veins of your body, you may require a temporary stop of using Xigduo XR.

There is a chance that you will suffer from the condition known as lactic acidosis. It is a risky buildup of acid within your blood. Contact your physician or seek emergency medical attention in the event of unusual muscle pain, breathing difficulties, stomach pains, dizziness, experiencing coldness, or feeling exhausted or weak.In rare instances, the medicine may cause serious infections of the vagina or the penis. Get medical help immediately if you experience burns, itchiness, smell, discharge, pain or swelling, redness, tenderness of the rectal or genital region, fever, or are not feeling well.

Before you take this drug

It is not recommended to use the XigduoXR if you're sensitive to dapagliflozin (Farxiga) or metformin or are suffering from:

  • Serious kidney condition (or if you're dialysis-dependent)
  • Diabetes, ketoacidosis, and metabolic acidosis (call your doctor to seek treatment).

To ensure that Xigduo XR is safe for you, consult your physician, whether you've ever:

  • Kidney or liver disease;
  • Lower blood pressure;
  • A urine infection or urinary tract problem;
  • Heart conditions heart problems, low blood pressure
  • Problems with your pancreas, which includes surgery for pancreas problems;
  • If you're on a diet low in salt.

It is possible to be diagnosed with an illness called lactic acidosis. This is an extremely dangerous accumulation of lactic acid in your blood. It is more likely in the event of another medical condition, such as a severe infection or persistent alcoholism, or if you are older than 65. Talk to your doctor about the risk you are taking.

Follow the directions of your doctor concerning XigduoXR when you are expecting. Blood sugar control is crucial during pregnancy. Your dosage requirements may differ throughout each trimester.Contact your physician immediately if you fall pregnant. You shouldn't use metformin and dapagliflozin in the third or second trimester of pregnancy.

Metformin can stimulate ovulation in premenopausal women and increase the risk of unintentional pregnancy. Consult your physician regarding your risks.

It is not recommended to breastfeed when using Xigduo XR.

Xigduo XR is not approved to be used by anyone younger than 18 years old.

How to take Xigduo XR?

Use Xigduo XR extended-release tablets exactly as directed by your physician. Follow the directions on the prescription label and study all medication guides or instruction sheets. The doctor might alter your dosage.

Your doctor might run kidney function tests before you begin treatment with Xigduo XR.Eat with food to avoid an upset stomach.Suck the tablet up whole. Don't chew, crush, or break the extended-release tablet.

It is possible that you have insufficient levels of blood sugar (hypoglycemia) and feel extremely hungry, dizzy, angry, and anxious. You may also feel confused, disoriented, or even shaky. To treat hypoglycemia quickly, consume or drink a rapid-acting sugar source (fruit juice crackers, hard candy, raisins, or other non-diet drinks).The doctor might prescribe the glucagon injection kit in the event that you suffer from severe hypoglycemia. Make sure your family or friends are aware of how to administer the injection in an emergency.

Be on the lookout for indications of high levels of blood sugar (hyperglycemia), such as an increase in thirst or increased urination.The levels of blood sugar are altered due to stress or illness, surgical procedures, exercise, alcohol consumption, or eating infrequently. Talk to your doctor before altering your dosage or medication schedule.Contact your physician if you are experiencing persistent nausea or diarrhoea or are sweating more frequently than normal. It is easy to get dehydrated when taking this medication, which can cause extremely low blood pressure or a significant electrolyte imbalance.If you require an operation or medical test, inform your doctor that you're taking Xigduo XR.This medication is only a part of a treatment plan that could also include exercise, diet, controlling weight, blood sugar tests, and medical treatment. Follow the instructions of your doctor carefully.Your kidney function could require a check while you receive treatment with Xigduo.Your doctor might suggest that you take additional vitamin B12 in conjunction with Xigduo XR. Only take the vitamin B12 that your doctor has advised.

Keep the items at room temperature, far from heat and moisture.

Details on dosage

Usual Adult Dose of Xigduo XR for Diabetes Type 2:

Individually adjust doses based on the current treatment regimen.
Maintain dose: Drink orally, once per day. Gradually increase depending on the effectiveness and tolerability.
Maximum dose: Dapagliflozin 10 mg/metformin 2000 mg per day
Patients who are taking a dose at night of metformin XR must avoid their last dose prior to taking this medication; take this medication once a day in the morning with breakfast.
If used in conjunction with insulin and insulin secretagogue, smaller doses of insulin and insulin secretagogue could be considered to decrease the risk of hypoglycemia.
Use: As an add-on to exercise and diet to help improve the control of glycemic levels in individuals suffering from the condition of type 2 diabetes, when treatments with Xigduo XR are appropriate.

What happens if I miss a dose?

Do the medication (with food) immediately if you are able, but don't take your missed dose in case you are nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

For medical emergencies, seek immediate medical attention, contact emergency medical attention, or call the Poison Help line at 1-800-222-1222. There is a possibility that you are suffering from a severe drop in glucose levels (extreme weakness and nausea, tremors or nausea, sweating, confusion, difficulty speaking, rapid heartbeats, or seizures).

What should be avoided?

Do not drink alcohol. It reduces blood sugar levels and increases the chance of contracting lactic acidosis.

Be careful not to get up too fast from a lying or sitting position. You could get dizzy.

Side effects of Xigduo XR

Get immediate medical attention. If you show symptoms of an allergy reaction to the Xigduo, such as hives, breathing difficulties, or swelling of your lips, face, or tongue,

You should seek medical attention immediately if you notice symptoms of a genital infection (penis or vagina): burning, itching, discharge, odour, redness, tenderness, pain, or swelling in the rectal or genital area, as well as feeling nwell. These symptoms could worsen rapidly.

Contact your doctor immediately. If you suffer from:

  • Minimal or no urination
  • Symptoms of a bladder infection: burning or pain whenever you go to the bathroom; more urine output; blood in your urine; fever; discomfort in your pelvis or lower back;
  • The dehydration symptoms symptoms include dizziness, a weak sensation of lightheadedness (like you're about to pass out),
  • Ketoacidosis (too much acidity in the blood): nausea, stomach pain, vomiting, disorientation, unusual drowsiness, or difficulty breathing;
  • Lactic acidosis: atypical muscle pain, difficulty breathing, nausea, stomach pain or irregular heartbeat, dizziness, feeling cold, or feeling extremely fatigued or weak

Some side effects are more likely to occur in older adults.

The most common Xigduo XR side effects may include:

  • Genital infections;
  • Headache;
  • Nausea, vomiting, diarrhea;
  • Runny or stuffy nasal passages; sore throat

This isn't a complete list of possible side effects, and other side effects could be present. Consult your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Discuss with your doctor all other medicines you take, including:

  • Digoxin (digitalis, lanoxin);
  • Rifampin;
  • Phenytoin;
  • Diuretic, also known as a "water pill";
  • Insulin, or other oral diabetes medications, and
  • There are many nsaid (nonsteroidal anti-inflammatory medicines): aspirin, ibuprofen (advil, motrin), naproxen (aleve), celecoxib, diclofenac (also known as indomethacin), diclofenac, diclofenac, and many more.

This list isn't comprehensive. Other medications can be incompatible with dapagliflozin as well as metformin, which includes prescription and over-the-counter medicines such as vitamins, medicines, or natural products. There are many possible interactions between drugs, which are listed here.




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